Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitors of Nitric Oxide Production from Artemisia princeps

  • Li, Dayu (College of Pharmacy, Chungbuk National University) ;
  • Han, Xiang Hua (College of Pharmacy, Chungbuk National University) ;
  • Hong, Seong-Su (College of Pharmacy, Chungbuk National University) ;
  • Lee, Chul (College of Pharmacy, Chungbuk National University) ;
  • Lee, Moon-Soon (College of Agriculture, Life & Environmental Sciences, Chungbuk National University) ;
  • Lee, Dong-Ho (School of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Mi-Kyeong (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
  • Received : 2010.06.12
  • Accepted : 2010.08.25
  • Published : 2010.09.30
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Abstract

The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1 - 3 inhibited nitric oxide production with $IC_{50}$ values of 19.5, 20.4 and 25.1 ${\mu}M$, respectively.

Keywords

References

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