Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Memory Enhancing Properties of the Ethanolic Extract of Black Sesame and its Ameliorating Properties on Memory Impairments in Mice

마우스에서 흑지마 에탄올 추출물의 기억력 증진 효과 및 기억력 감퇴에 대한 개선 효과

  • Kim, Jong-Min (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Park, Se-Jin (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Jung, Ji-Wook (Department of Herbal Medicinal Resource, College of Health and Welfare, Daegu Haany University) ;
  • Ryu, Jong-Hoon (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
  • 김종민 (경희대학교 나노의약생명과학과) ;
  • 김동현 (경희대학교 나노의약생명과학과) ;
  • 박세진 (경희대학교 나노의약생명과학과) ;
  • 정지욱 (대구한의대학교 한약재약리학과) ;
  • 류종훈 (경희대학교 나노의약생명과학과)
  • Received : 2010.08.16
  • Accepted : 2010.09.08
  • Published : 2010.09.30
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Abstract

Black sesame (Sesami semen nigrum) has been used to treat dizziness, earnoise, constipation in the traditional Chinese medicine. In the present study, we assessed memory enhancing properties of 70% ethanolic extract of black sesame (EBS70) and its ameliorating activities on learning and memory impairments induced by scopolamine. Drug-induced amnesia was made by scopolamine treatment (1 mg/kg, i.p.). Single EBS70 (200 mg/kg, p.o.) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks (P<0.05) and also reduced escape-latency on the Morris water maze task (P<0.05). In addition, EBS70 increased BDNF expression in hippocampus 4 h after its administration (P<0.05). These results suggest that EBS70 enhances learning and memory in normal state and attenuates amnesic state caused by cholinergic dysfunction.

Keywords

References

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