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  • 제10권1호
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  • Pages.1-4
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  • 2010
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

DOI QR Code

Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma

  • Nakajima, Hiroshi (Department of Molecular Genetics, Graduate School of Medicine, Chiba University) ;
  • Hirose, Koichi (Department of Allergy and Clinical Immunology, Chiba University Hospital)
  • 투고 : 2010.01.27
  • 심사 : 2010.02.09
  • 발행 : 2010.02.28
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초록

Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing $CD4^+$ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.

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참고문헌

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