Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Effect of Dextran Gel on Preparation of Nano-liposomes Loaded with Ginkgolide

  • Tong, Yuan (School of Life Science, Anhui University) ;
  • Chen, Yan (School of Life Science, Anhui University) ;
  • Pan, Jian (Engineering Research Center of Bio-Process, Hefei University of Technology, Ministry of Education) ;
  • Huang, Li (School of Life Science, Anhui University) ;
  • Wang, Ruijun (School of Life Science, Anhui University)
  • Received : 2010.03.23
  • Accepted : 2010.07.22
  • Published : 2010.09.20
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Abstract

The objective of this paper was to investigate the effect of dextran gel on preparation of nano-liposomes loaded with ginkgolide. During preparation, Sephadex G75, G50 and G25 were added in the aqueous phase respectively. From the experiment, nano-liposomes prepared by dextran gels were found spherical and smooth. The result indicated that aperture of dextran gels were narrower, particle size of nano-liposomes was smaller (207.13 ~ 89.16 nm) and zeta potential was greater (-36.2 ~ -29.5 mV) in more negative. The study also revealed that differences of the entrapment efficiency and drug loading among the three types of nano-liposomes were not significant. In vitro drug release test demonstrated that nano-liposomes had a better controlled release. To conclude, by using dextran gel in the preparation of nano-liposome loaded with ginkgolide, the particle size could be effectively controlled and the drug stability could be improved.

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References

  1. Ahlemeyer, B.; Krieglstein, J. J. Cell. Mol. Life Sci. 2003, 60, 1779. https://doi.org/10.1007/s00018-003-3080-1
  2. Sakakibara, H.; Izawa, Y.; Nakajima, J.; Seo, S.; Tamaki, T.; Kawai, Y.; Terao, J. Functional Food and Health; University Press: Oxford, U. K., 2008; p 429.
  3. Chen, Z. Y.; Peng, C.; Jiao, R.; Wong, Y. M.; Yang, N.; Huang, Y. J. Agric. Food Chem. 2009, 57, 4485. https://doi.org/10.1021/jf900803r
  4. Mauri, P.; Simonetti, P.; Gardana, C.; Minoggio, M.; Morazzoni, P.; Bombardelli, E.; Pietta, P. J. Rapid commun Mass Spectrom. 2001, 15, 929. https://doi.org/10.1002/rcm.316
  5. Lv, H.; Wang, G. J.; Li, H.; Huang, M. W.; Xie, H. T.; Huang, C. R.; Sun, J. G.; Lv, T. J. Pharm. Biom. 2006, 40, 88. https://doi.org/10.1016/j.jpba.2005.06.004
  6. Müller, R. H.; Maaβen, S.; Weyhers, H.; Specht, F.; Lucks, J. S. Int. J. Pharm. 1996, 138, 85. https://doi.org/10.1016/0378-5173(96)04539-5
  7. Dimitrov, D. S. J. Colloids Surf. A 2006, 282, 8. https://doi.org/10.1016/j.colsurfa.2005.11.001
  8. Liu, G.; Men, P.; Harris, P. L. R.; Rolston, R. K.; Perry, G.; Smith, M. A. J. Neurosci Lett. 2006, 406, 189. https://doi.org/10.1016/j.neulet.2006.07.020
  9. Schnyder, A.; Huwyler, J. J. Neurotherapeutics 2005, 2, 99. https://doi.org/10.1602/neurorx.2.1.99
  10. Kim, K.; Lee, M.; Park, H.; Kim, J. H.; Kim, S. W.; Chung, H.; Choi, K.; Kim, I. S.; Seong, B. L.; Kwon, I. C. J. Am. Chem. Soc. 2006, 128, 3490. https://doi.org/10.1021/ja057712f
  11. Moura, M. R.; Aouada, F. A.; Mattoso, L. H. C. J. Colloid Interface Sci. 2008, 321, 477. https://doi.org/10.1016/j.jcis.2008.02.006
  12. Farah, A. A.; Alvarez-Puebla, R. A.; Fenniri, H. J. Colloid Interface Sci. 2008, 319, 572. https://doi.org/10.1016/j.jcis.2007.11.030
  13. Muller, R. H.; Mäder, K.; Gohla, S. Euro. J. Pharm. Biopharm. 2000, 50, 161. https://doi.org/10.1016/S0939-6411(00)00087-4
  14. Abra, R. M.; Hunt, C. A. J. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1981, 666, 493. https://doi.org/10.1016/0005-2760(81)90311-8
  15. An, S. Y.; Bui, M. N.; Nam, Y. J.; Han, K. N. J. Colloid Interface Sci. 2009, 331, 98. https://doi.org/10.1016/j.jcis.2008.11.022
  16. Mathai, J. C.; Sitaraman, V. J. Biochemical Education 1987, 15, 147. https://doi.org/10.1016/0307-4412(87)90052-5
  17. Pham, H. L.; Shaw, P. N.; Davies, N. M. J. Int. Pharm. 2006, 310, 196. https://doi.org/10.1016/j.ijpharm.2005.11.011
  18. Dubber, M.-J.; Kanfer, I. J. Pharm. Biom. 2006, 41, 135. https://doi.org/10.1016/j.jpba.2005.11.010
  19. Mesbah, M. K.; Khalifa, S. I.; El-Gindy, A.; Tawfik, K. A. J. IL Farmaco 2005, 60, 583. https://doi.org/10.1016/j.farmac.2005.01.014
  20. Mesbah, M. K.; Khalifa, S. I.; El-Gindy, A.; Tawfik, K. A. J. IL Farmaco 2005, 60, 583. https://doi.org/10.1016/j.farmac.2005.01.014
  21. Subedi, R. K.; Kang, K. W.; Choi, H. K. Euro. J. Pharm. 2009, 37, 508. https://doi.org/10.1016/j.ejps.2009.04.008
  22. Schwab, M.; Kessler, B.; Wolf, E.; Jordan, G.; Mohl, S.; Winter, G. J. Euro. Pharm. Biopharm. 2008, 70, 690. https://doi.org/10.1016/j.ejpb.2008.05.010
  23. Larsen, S. W.; Frost, A. B.; Ostergaard, J.; Marcher, H.; Larsen, C. J. Euro. Pharm. Sci. 2008, 34, 37. https://doi.org/10.1016/j.ejps.2008.02.005
  24. Mourtas, S.; Fotopoulou, S.; Duraj, S.; Sfika, V.; Tsakiroglou, C.; Antimisiaris, S. G. J. Colloids and Surfaces B: Biointerfaces 2007, 55, 212. https://doi.org/10.1016/j.colsurfb.2006.12.005
  25. Liu, K. S.; Tzeng, J. I.; Chen, Y. W.; Huang, K. L.; Kuei, C. H.; Wang, J. J. Anesth. Analg. 2006, 102, 1445. https://doi.org/10.1213/01.ane.0000205747.05693.30
  26. Kuo, Y. C.; Chen, H. H. Int. J. Pharm. 2009, 365, 206.
  27. Merodio, M.; Arnedo, A.; Renedo, M. J.; Irache, J. M. J. Euro. Pharm. Sci. 2001, 12, 251. https://doi.org/10.1016/S0928-0987(00)00169-X
  28. Li, Y. C.; Dong, L.; Jia, A.; Chang, X. M.; Xue, H. J. Int. Bio. Macromolecules 2006, 38, 296. https://doi.org/10.1016/j.ijbiomac.2006.03.006

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