Journal of Plant Biotechnology

The Korean Society of Plant Biotechnology (한국식물생명공학회)
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Plants as platforms for the production of vaccine antigens

항원 생산 기반으로서의 식물 연구

  • 염정원 (한국생명공학연구원 식물시스템공학연구센터) ;
  • 전재흥 (한국생명공학연구원 식물시스템공학연구센터) ;
  • 정혁 (한국생명공학연구원 식물시스템공학연구센터) ;
  • 김현순 (한국생명공학연구원 식물시스템공학연구센터)
  • Received : 2010.08.02
  • Accepted : 2010.08.16
  • Published : 2010.09.30
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Abstract

The expression of vaccine antigens in transgenic plants has the potential to provide a convenient, stable, safe approach for oral vaccination alternative to traditional parenteral vaccines. Over the past two decades, many different vaccine antigens expressed via the plant nuclear genome have elicited appropriate immunoglobulin responses and have conferred protection upon oral delivery. Up to date, efforts to produce antigen proteins in plants have focused on potato, tobacco, tomato, banana, and seed (maize, rice, soybean, etc). The choice of promoters affects transgene transcription, resulting in changes not only in concentration, but also in the stage tissue and cell specificity of its expression. Inclusion of mucosal adjuvants during immunization with the vaccine antigen has been an important step towards the success of plant-derived vaccines. In animal and Phase I clinical trials several plant-derived vaccine antigens have been found to be safe and induce sufficiently high immune response. Future areas of research should further characterize the induction of the mucosal immune response and appropriate dosage for delivery system of animal and human vaccines. This article reviews the current status of development in the area of the use of plant for the development of oral vaccines.

Keywords

References

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