Journal of Plant Biotechnology

The Korean Society of Plant Biotechnology (한국식물생명공학회)
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Current status in molecular farming

분자농업의 현황 및 전망

  • Kim, Tae-Geum (Department of Molecular Biology, Chonbuk National University, Jeonju Center, Korea Basic Science Institute) ;
  • Yang, Moon-Sik (Department of Molecular Biology, Chonbuk National University, Jeonju Center, Korea Basic Science Institute)
  • 김태금 (전북대학교 자연과학대학 분자생물학과) ;
  • 양문식 (전북대학교 자연과학대학 분자생물학과)
  • Received : 2010.08.02
  • Accepted : 2010.08.16
  • Published : 2010.09.30
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Abstract

Molecular farming is production of pharmaceutically and industrially important proteins in plants. Plants and plant cell culture systems have been used as bio-factory to produce recombinant proteins such as monoclonal antibodies, enzymes, vaccines, hormones, interleukins, commercial enzymes and etc. The terms molecular farming, biofarming, molecular pharming, phytomanufacturing, recombinant or plant-made industrials, planta-pharma, plant bioreactors, plant biofactory, and pharmaceutical gardening are used interchangeably. Molecular farming can provide safe and inexpensive pharmaceutical proteins as well as commercial ones. In spite of several advantages of molecular farming such as safety and inexpensive cost, there are also a couple of drawbacks in the existing technology. One of them is low expression level of target gene in plants, which has been improved by optimizing gene-based codon usage, screening of strong promoters, expression of transcription factors, subcellular targeting of target proteins, chloroplast transformation, and transient expression using viral expression system (magnifection). Some plant-based commercial proteins have already been in markets and more than twenty plant-based pharmaceuticals have been in clinical trials, from that we can expect that several plant-based pharmaceutical proteins will be seen in the markets in the near future.

Keywords

References

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