Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Vitamin B6 Requirement: Indicators and Factors Affecting

비타민 B6 필요량: 영양상태 판정지표 및 영향요인

  • Cho, Youn-Ok (Department of Food and Nutrition, Ducksung Women's University)
  • 조윤옥 (덕성여자대학교 식품영양학과)
  • Received : 2010.04.09
  • Published : 2010.06.30
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Abstract

The purpose of this study was to establish the selection of indicators for estimating and factors affecting the requirement of vitamin B6. There has been a need to establish the human requirements of vitamin $B_6$ since vitamin $B_6$ is thought to be involved in more than one hundred biochemical reactions as a coenzyme in the metabolism of amino acids, glucose, and lipid, and the synthesis of neurotransmitters. For the review of the literature, this study included from early findings of the sixties to studies of 2009. This study suggests that plasma pyridoxal 5' phosphate (PLP) is the best single indicator of vitamin $B_6$ status for the healthy but not for the non-healthy. Erythrocyte aspartate aminotransferase and alanine aminotransferase activation by PLP as an indirect measure and urinary 4-pyridoxic acid excretion as a direct measure are useful as supporting indicators. Bioavailability, nutrient interaction, physiological need, and chronic diseases may increase the requirement for vitamin $B_6$. However, these effects can not be quantified due to insufficient evidences.

Keywords

References

  1. Rybak ME, Jain RB, Pfeiffer CM. Clinical vitamin $ B_6$analysis: an interlaboratory comparison of pyridoxal 5'-phosphate measurement in serum. Clin Chem 2005; 51: 1223-1231 https://doi.org/10.1373/clinchem.2005.050278
  2. Lumeng L, Li TK. Vitamin B6 metabolism in chronic alcohol abuse. Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation in human erythrocytes. J Clin Invest 1974; 53: 693-704 https://doi.org/10.1172/JCI107607
  3. Lumeng L, Ryan MP, Li TK. Validation of diagnostic value of plasma pyridoxal phosphate measurements in vitamin$ B_6$nutrition of the rats. J Nutr 1978; 108: 545-553
  4. Lui A, Lumeng L, Aronoff GR, Li TK. Relationship between body store of vitamin $ B_6$ and plasma pyridoxal-P clearance: Metabolic balance studies in humans. J Lab Clin Med 1985; 106: 491- 497
  5. Bor MV, Refsum H, Bisp MR, Bleie O, Schneede J, Nordrehaug JE, Ueland PM, Nygard OK, Nexo E. Plasma vitamin $ B_6$ vitamers before and after oral vitamin $ B_6$ treatment: a randomized placebocontrolled study. Clin Chem 2003; 49:155-161 https://doi.org/10.1373/49.1.155
  6. Leklem JE. Vitamin $ B_6$: A status report. J Nutr 1990; 120: 1503- 15087
  7. Cho Y, Kim B. Evaluation of vitamin $ B_6$status and RDA in young Koreans. Ann Nutr Met 2004; 48;235-240 https://doi.org/10.1159/000080456
  8. Lim MY, Nam YS, Kim SS, Chang NS. Vitamin B stalus and scrum homocysteinc levels in infertile woman. Korean J Nutr 2004; 37: 115-122
  9. Lin PT, Cheng CH, Liaw YP, Lee BJ, Lee TW, Huang YC. Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease. Nutrition 2006; 22: 1146-1151 https://doi.org/10.1016/j.nut.2006.08.013
  10. Chang SJ, Hsiao LJ, Lee YC, Hsuen SY. Vitamin $ B_6$ status assessment in relation to dietary intake in high school student aged 16-18 years. Br J Nutr 2007; 97: 764-769 https://doi.org/10.1017/S0007114507665167
  11. Huang YC, Chang HH, Huang SC, Cheng CH, Lee BJ, Cheng SY, Su KH. Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. Nutrition 2005; 21: 779-785 https://doi.org/10.1016/j.nut.2004.11.013
  12. Chiang EP, Bagley PJ, Roubenoff R, Nadeau M, Selhub J. Plasma pyridoxal 5'-phosphate concentration is correlated with functional vitamin$ B_6$indices in patients with rheumatoid arthritis and marginal vitamin $ B_6$ status. J Nutr 2003; 133: 1056-1059
  13. Chabner B, Livington DA. A simple enzymic assay for pyridoxal phosphate. Anal Biochem 1970; 34: 413-423 https://doi.org/10.1016/0003-2697(70)90126-0
  14. Han Q, Xu M, Tang L, Tan X, Tan X, Tan Y. Homogeneous nonradioactive, enzymatic assay for plasma pyridoxal 5'-phosphate. Clin Chem 2002; 48: 1560-1564
  15. Bisp MR. Bor MV, Heinsvig EM, Kall MA. Nexo E. Determination of vitamin $ B_6$vitamers and pyridoxic acid in plasma: development and evaluation of a high performance liquid chromatographic assay. Anal Biochem 2002; 305: 82-89 https://doi.org/10.1006/abio.2002.5638
  16. Rybak ME, Pfeiffer CM. Clinical analysis of vitamin$ B_6$: determination of pyridoxal 5'-phosphate and 4-pyridoxic acid in human serum by reversed-phase high performance liquid chromatography with chlorite postcolumn derivatization. Anal Biochem 2004; 333: 336-344 https://doi.org/10.1016/j.ab.2004.06.036
  17. Bates CJ, Pentieva KD, Matthew N, Macdonald A. A simple, sensitive and reproducible assay for pyridoxal 5'-phosphate and 4-pyridoxic acid in human plasma. Clin Chimica Acta 1999; 280: 101-111 https://doi.org/10.1016/S0009-8981(98)00173-9
  18. Brown RP, Rose DP, Leklem JE, Linkswiler H, Anand R. Urinary 4-pyridoxic acid, plasma pyridoxal phosphate, and erythrocyte aminotransferase levels in oral contraceptive users receiving controlled intakes of vitamin $ B_6$. Am J Clin Nutr 1975; 28: 10-19
  19. Kretsch MJ, Sauberlich HE, Skala JH, Johnson HL. Vitamin B6 requirement and status assessment: young women fed a depletion diet followed by a plant or animal-protein diet with graded amounts of vitamin$ B_6$. Am J Clin Nutr 1995; 61:1091-1101
  20. Hansen CM, Leklem JE, Miller LT. Changes in vitamin $ B_6$ status indicators of women fed a constant protein diet with varying levels of vitamin $ B_6$. Am J Clin Nutr 1997; 66: 1379-1387
  21. Rose RC, McCormick DB, Li TK, Lumeng L, Haddad JG Jr. Spector R. Transport and metabolism of vitamins. Fed Proc 1986;45: 30-39
  22. Brown RR. The tryptophan load test as an index of vitamin $ B_6$ nutrition. In: Leklem JE, Reynolds RD eds. Methods in vitamin $ B_6$ nutrition. New York: Plenum Press; 1981. pp321-340
  23. Brown RR. Possible role for vitamin$ B_6$metabolism in cancer prevention and treatment. In: Leklem JE, Reynolds RE eds. Clinical and physiological application of vitamin $ B_6$. New York: Liss; 1988. p.279-301
  24. Linkswiler HM. Methionine metabolism excretion as affected by a vitamin $ B_6$ deficiency. In: Leklem JE, Reynolds JE eds. Methods in vitamin $ B_6$ nutrition. New York: Plenum Press; 1981. p.373-381
  25. Leklem JE. Bioavailability of vitamins; application of human nutrition. In: Dobernz AR, Milner JA, Schweigert BS, eds. Foods and agricultural research opportunities to improve human nutrition. Newark: University of Delaware; 1986. p.A56-A73
  26. Tarr JB, Tamura T, Stokstad EL. Availability of vitamin$ B_6$and pantothenate in an average American diet in man. Am J Clin Nutr 1981; 34: 1328-1337
  27. Gregory JF. Bioavailability of vitamin $ B_6$. Eur J Clin Nutr 1997; 51: S43- S48
  28. Shane B. Vitamin $ B_6$ and blood. In: Human Vitamin$ B_6$requirements: Proceedings of a workshop. Washington, DC: National Academy Press; 1978. pp111-128
  29. Wozenski JR, Leklem JE, Miller LT. The metabolism of small doses of vitamin $ B_6$ in men. J Nutr 1980; 110: 275-285
  30. Waldmann A, Do B, Koschizke JW, Leitzmann C, Hahn A. Dietary intake of vitamin $ B_6$ and concentration of vitamin $ B_6$in blood samples of German vegan. Pub Health Nutr 2006; 9: 779-784
  31. Huang YC, Chen W, Evans MC, Mitchell ME, Shultz TD. Vitamin $ B_6$requirement and status assessment of young women fed a high protein diet with various levels of vitamin $ B_6$. Am J Clin Nutr 1998; 67: 208-20
  32. Ribaya-Mercado JD, Russell RM, Sahyoun N, Marrow FD, Gershoff SN. Vitamin $ B_6$ Requirements of elderly men and women. J Nutr 1991; 121: 1062-1074
  33. Miller LT, Leklem JE, Shultz TD. The Effect of protein on the metabolism of vitamin $ B_6$ in humans. J Nutr 1985; 115: 1663- 1672
  34. Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008; 87: 1446-1454
  35. Pennemans DL, van den Berg H, Westerterp KR. The influence of protein intake on vitamin $ B_6$ metabolism differs in young and elderly humans. J Nutr 1994; 124: 1207-1214
  36. Hofmann A, Reynolds RD, Somoak BL, Villanueva VG, Deuster PA. Plasma pyridoxal and pyridoxal 5'-phosphate concentration in response to ingestion of water or glucose polymer during a 2- h run. Am J Clin Nutr 1991; 53: 84-89
  37. Ferroli CE, Trumbo PR. Bioavailability of vitamin $ B_6$ in young and older man. Am J Clin Nutr 1994; 60: 68-71
  38. Rose CS, Gyorgy P, Butler M. Age differences in vitamin $ B_6$status of 617 men. Am J Clin Nutr 1976; 29: 847-853
  39. Lee CM, Leklem JE. Differences in vitamin$ B_6$status indicator response between young and middle aged women fed constant diets with levels of vitamin $ B_6$. Am J Clin Nutr 1985; 42: 226-234
  40. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270: 2693-2698 https://doi.org/10.1001/jama.270.22.2693
  41. Shane B, Contractor SF. Vitamin $ B_6$status and metabolism in pregnancy. In: Tryfiates GP, ed. Vitamin $ B_6$ metabolism and role in growth. Westport: Food & Nutrition Press; 1980. p.131-171
  42. Contractor SF, Shane B. Blood and urine levels of vitamin $ B_6$in the mother and fetus before and after loading of the mother with vitamin $ B_6$. Am J Obstet Gynecol 1970; 107: 635-640
  43. Contractor SF, Shane B. Metabolism of 14C pyridoxal in pregnant rat. Biochim Biophys Acta 1971; 230: 127-136
  44. Kim HS, Kim YJ, Chang NS. Effects of matcrnal 5,10 methylenetetrahydrofolate reductase (MTHFB) genotype, serom homoeysteine and B vitamin levels on postnatal growth in their offsprings. Korean J Nutr 2006; 39: 264-273
  45. Shane B, Contractor SF. Assessment of vitamin $ B_6$ status: Studies on pregnant women and oral contraceptive agent users. Am J Clin Nutr 1975; 28: 739-747
  46. Ahn HS, Lee GJ, Chang HY. Maternal vitamin $ B_6$ intake and vitamin $ B_6$ level in matornal, umbilical cord plasma and placenla. Korean J Nutr 2002; 35: 322-331
  47. Kang SA. Vitamin $ B_6$ status of mothers: Relation to condition of newborn and the neonate. Korean J Nutr 1993; 26: 867-886
  48. Gaynor R, Dempsey WB. Vitamin $ B_6$ enzymes in normal and pre-eclamptic human placentae. Clin Chim Acta 1972; 37: 411- 416 https://doi.org/10.1016/0009-8981(72)90463-9
  49. Kang-Yoon SA, Kirksey A, Giacoia G, West K. Vitamin $ B_6$ status of breast-fed neonates: influence of pyridoxine supplementation on mothers and neonates. Am J Clin Nutr 1992; 56: 548-558
  50. Chang SJ, Kirksey A. Vitamin$ B_6$status of breast-fed infants in relation to pyridoxine HCl supplementation of mothers. J Nutr Sci Vitaminol 2002; 48: 10-17 https://doi.org/10.3177/jnsv.48.10
  51. Chun YM, Kim YJ, Chang NS. Effects of maternal dictary intakes and health related behaviors on vitamin B concentrations in human milk. Korean J Nutr 2005; 38: 313-319
  52. Crozier PG, Cordain L, Dampson DA. Exercise-induced changes in plasma vitamin $ B_6$ concentrations do not vary with exercise intensity. Am J Clin Nutr 1994; 60: 552-558
  53. Leklem JE, Shultz TD. Increased plasma pyridoxal 5'-phosphate and vitamin$ B_6$in male adolescents after 4500-meter run. Am J Clin Nutr 1983; 38: 541-548
  54. Leonard SW, Leklem JE. Plasma $ B_6$vitamer changes following a 50-km ultra-marathon. Int J Sport Nutr Exer Metab 2000; 10: 302-314
  55. Manore MM, Leklem JE, Walter MG. Vitamin $ B_6$metabolism as affected by exercise in trained and untrained women fed diets differing in carbohydrate and vitamin $ B_6$ content. Am J Clin Nutr 1987; 46: 995-1004
  56. Choi E, Cho Y. Vitamin $ B_6$ deficiency can reduce fuel storage and utilization in physically trained rats. Int J Vit Nutr Res 2008; 78: 64-69 https://doi.org/10.1024/0300-9831.78.2.64
  57. Choi E, Cho Y. Effect of vitamin $ B_6$ deficiency on antioxidative status in rats with exercised-induced oxidative stress. Nutr Res Pract 2009; 3: 208-211 https://doi.org/10.4162/nrp.2009.3.3.208
  58. van der Beek EJ, van Dokkum W, Wedel M, Schrijver J, van der Berg H. Thiamin, riboflavin and vitamin $ B_6$: Impact of restricted intake on physical performance in man. J Am Coll Nutr 1994; 13: 629-640
  59. Spence JD. Patients with atherosclerotic vascular disease: how low should plasma homocysteine levels go? Am J Cardiovasc Drugs 2001; 1: 85-86 https://doi.org/10.2165/00129784-200101020-00002
  60. Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman J. Low circulating folate and vitamin $ B_6$ concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation 1998; 97: 437- 446
  61. Folsom AR, Desvarieux M, Nieto FJ, Boland LL, Ballantyne CM, Chambless LE. B vitamin status and inflammatory markers. Atherosclerosis 2003; 169: 169-174 https://doi.org/10.1016/S0021-9150(03)00161-8
  62. Rimm EB, Willet WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampfer MJ. Folate and vitamin $ B_6$from diet and supplements in relation to risk of coronary heart disease among women. JAMA 1998; 279: 359-364 https://doi.org/10.1001/jama.279.5.359
  63. He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC, Ascherio A. Folate, vitamin $ B_6$, and $ B_12$ intakes in relation to risk of stroke among men. Stroke 2004; 35: 169-174
  64. Kelly PJ, Shih V, Kristler JP, Barron M, Lee H, Mandell R, Furie KL. Low vitamin $ B_6$, but not homocysteine, is associated with increased risk of stroke and transient ichemic attack in the era of folic acid grain fortification. Stroke 2003; 34: e51-e54 https://doi.org/10.1161/01.STR.0000071109.23410.AB
  65. Page JH, Ma J, Chiuve SE, Stampfer MJ, Selhub J, Manson JE, Rimm EB. Plasma vitamin $ B_6$ and risk of myocardial infarction in women. Circulation 2009; 120: 649-655 https://doi.org/10.1161/CIRCULATIONAHA.108.809038
  66. Friso S, Jacques PF, Wilson PWF, Rosengerg IH, Selhub J. Low circulating vitamin $ B_6$is associated with elevation of the inflammation marker C-ractive protein independently of plasma homocysteine levels. Circulation 2001; 103: 2788-2791
  67. Friso S, Girelli D, Martinelli N, Olivieri O, Lotto V, Bozzini C. Low plasma vitamin $ B_6$ concentrations and modulation of coronary artery disease risk. Am J Clin Nutr 2004; 79: 992-998
  68. Kelly PJ, Kristler JP, Shih V, Mandell R, Atassi N, Barron M, Lee H, Silveira S, Furie KL, Inflammation, homocysteine, and vitamin $ B_6$ status after ischemic stroke. Stroke 2004; 35: 12-15
  69. Paukionis L, Kane SL. Meckling KA. Vitamin status and cognitive function in a long-term care population. BMC Geriatr 2005; 5: 16 https://doi.org/10.1186/1471-2318-5-16
  70. Seshadri S. Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease? J Alzheimer Dis 2006; 9: 393-398
  71. Miller JW. Green R, Mungas DM, Reed BR, Jagust WJ, Homocysteine, vitamin $ B_6$, and vascular disease in AD patients. Neurology 2002; 58: 1471-1475
  72. Fassbender K, Mielke O, Bertsch T, Nafe B, Froschen S, Hennerici M. Homocysteine in cerebral macroangiography and microangiography. Lancet 1999; 353: 1586-1587 https://doi.org/10.1016/S0140-6736(99)00309-8
  73. Mulder C, Scheltens P, Barkhof F, Gundy C, Verstraeten RA, de Leeuw FE. Low vitamin $ B_6$ levels are associated with white matter lesions in Alzheimer's disease. J Am Geriatr Soc 2005; 53: 1073-1074 https://doi.org/10.1111/j.1532-5415.2005.53338_1.x
  74. Wilson RG, Davis RE. Serum pyridoxal concentrations in children with diabetes mellitus. Pathology 1977; 9: 95-98 https://doi.org/10.3109/00313027709085244
  75. Davis RE, Calder JS, Curnow DH. serum pyridoxal and folate concentrations in diabetics. Pathology 1976; 8: 151-156 https://doi.org/10.3109/00313027609094441
  76. Okada M, Shibuya M, Yamamoto E, Murakami Y. Effects of diabetes on vitamin $ B_6$ requirement in experimental animals. Diabetes Obes Metab 1999; 1: 221-225 https://doi.org/10.1046/j.1463-1326.1999.00028.x
  77. Constans J, Blann AD, Resplandy F, Parrot F, Renard M, Seigneur M, Guérin V, Boisseau M, Conri C. Three months supplementation of hyperhomocysteinaemic patients with folic acid and vitamin $ B_6$ improves biological markers of endothelial dysfunction. Br J Haematol 1999; 107: 776-778 https://doi.org/10.1046/j.1365-2141.1999.01780.x
  78. Mackenzie KE, Wiltshire EJ, Gent R, Hirte C, Piotto L, Couper JJ. Folate and vitamin $ B_6$ rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics 2006; 118: 242-253 https://doi.org/10.1542/peds.2005-2143
  79. Cigolini M, Lagulli MP, Miconi V, Lorenzi T, Lombardi S, Targher G. Inflammatory variables may mediate the link between low plasma vitamin $ B_6$ concentrations and cardiovascular disease in type 2 diabetes. Nutr Metabol Cardiovas Dis 2006; 16: e9-e10 https://doi.org/10.1016/j.numecd.2006.05.003
  80. Gorson KC, Ropper AH. Additional causes for distal sensory polyneuropathy in diabetic patients. J Neurol Neurosurg Psychiatry 2006; 77: 354-358
  81. Roubenoff R, Roubenoff RA, Selhub J, Nadeau MR, Cannon JG, Freeman LM, Dinarello CA, Rosenberg IH. Abnormal vitamin $ B_6$ status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation. Arthritis Rheum 1995; 38: 105-109 https://doi.org/10.1002/art.1780380116
  82. Chiang EP, Bagley PJ, Selhub J, Nadeau M, Roubenoff R. Abnormal vitamin $ B_6$ status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003; 114: 283- 287 https://doi.org/10.1016/S0002-9343(02)01528-0
  83. Chiang EP, Smith DE, Selhub J, Dallal G, Wang YC, Roubenoff R. Inflammation causes tissue-specific depletion of vitamin $ B_6$. Arthritis Res Ther 2005; 7: R1254-R1262 https://doi.org/10.1186/ar1821
  84. Chiang EP, Selhub J, Bagley PJ, Dallal G, Roubenoff R. Pyridoxine supplementation corrects vitamin $ B_6$ deficiency but does not improve inflammation in patients with rheumatoid arthritis. Arthritis Res Ther 2005; 7: R1404-R1411 https://doi.org/10.1186/ar1839
  85. Rose DP. Oral contraceptives and vitamin $ B_6$. Proceedings of a workshop on Human Vitamin $ B_6$ Requirement. Washington D.C: National Academy Press; 1978. p.193-201
  86. Bermond P. Therapy of side effects of oral contraceptive agents with vitamin $ B_6$. Acta Vitaminol Enzymol 1982; 4: 45-54
  87. Luhby AL, Brin M, Gordon M, Davis P, Murphy M, Spiegel H. Vitamin $ B_6$ metabolism in users of oral contraceptive agents. I. Abnormal urinary xanthurenic acid excretion and its correction by pyridoxine. Am J Clin Nutr 1971; 24: 684-693
  88. Aly HE, Donald EA, Simpson MH. Oral contraceptives and vitamin $ B_6$ metabolism. Am J Clin Nutr 1971; 24: 297-303
  89. Nutrition Review. The vitamin $ B_6$ requirement in oral contraceptive users. Nutr Rev 1979; 37: 344-345
  90. Bender DA. Effects of oestradiol and vitamin$ B_6$on tryptophan metabolism in rats: implications for the interpretation of the tryptophan load test for vitamin $ B_6$ nutritional status. Br J Nutr 1983; 50: 33-42 https://doi.org/10.1079/BJN19830069
  91. Leklem JE. Vitamin $ B_6$ requirement and oral contraceptive use-a concern? J Nutr 1986; 116: 475-477
  92. Lumeng L, Cleary RE, Li TK. Effect of oral contraceptives on the plasma concentration of pyridoxal phosphate. Am J Clin Nutr 1974; 27: 326-333
  93. Masse PG, Van den Berg H, Duguay C, Beaulieu G, Simard JM. Early effect of a low dose (30 micrograms) ethinyl estradiolcontaining Triphasil on vitamin $ B_6$ status. A follow-up study on six menstrual cycles. Int J Vit Nutr Res 1996; 66: 46-54
  94. Lussana F, Zighetti ML, Bucciarelli P, Cugno M, Cattaneo M. Blood levels of homocysteine, folate, vitamin $ B_6$ and vitamin $ B_12$in women using oral contraceptives compared to non-users. Thromb Res 2003; 112: 37-41 https://doi.org/10.1016/j.thromres.2003.11.007
  95. Vermaak WJ, Ubbink JB, Barnard HC, Potgieter GM, van Jaarsveld H, Groenewald AJ. Vitamin $ B_6$nutrition status and cigarette smoking. Am J Clin Nutr 1990; 51: 1058-1061

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