YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Acanthopanax koreanum Extracts on Anticancer Related Cytokine Secretions

섬오가피 추출물의 항암관련 사이토카인 분비활성

  • Lyu, Su-Yun (Dept. of Herbal Medicinal Pharmacology, Daegu Haany University) ;
  • Park, Won-Bong (Dept. of Chemistry, College of Natural Sciences, Seoul Women's University)
  • 유수연 (대구한의대학교 한약재 약리학과) ;
  • 박원봉 (서울여자대학교 자연과학대학 화학과)
  • Received : 2010.02.16
  • Accepted : 2010.05.12
  • Published : 2010.08.31
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Abstract

Stems and roots of Acanthopanax koreanum Nakai were extracted with water and treated on immune cells in order to determine their immunomodulatory activites. Various Th-1 type cytokines were measured using ELISA including interleukin (IL)-2, IL-12, interferon-gamma (IFN-$gamma$), and tumor necrosis factor-alpha (TNF-$\alpha$) secreted by dendritic cells, T-cells, intestinal epithelial cells, natural killer cells, and macrophages. As a result, there was a significant increase in IL-12 and IFN-$\gamma$, secretion, but there was no change in the secretion of TNF-$alpha$. Additionally T-cells slightly increased the secretion of IL-2, but there was a significant increase of IL-2 in intestinal epithelial cells. Therefore, our results suggest that A. koreanum Nakai may act as an immunomodulator by stimulating the cell-mediated immunity which can help the immune system defend against infections or cancer cells.

Keywords

References

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