한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제18권4호
  • /
  • Pages.238-243
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  • 2010
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

마우스에서 삼색제비꽃 추출물의 진통 효과와 매커니즘

Antinociception Effect and Mechanisms of Viola tricolor L. Extract in Mouse

  • 박수현 (한림대학교 의과대학 약리학교실) ;
  • 심윤범 (한림대학교 의과대학 약리학교실) ;
  • 서홍원 (한림대학교 의과대학 약리학교실) ;
  • 김진규 (한림대학교 천연의약연구소) ;
  • 이진구 (한림대학교 천연의약연구소) ;
  • 임순성 (한림대학교 천연의약연구소)
  • Park, Soo-Hyun (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Sim, Yun-Beom (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Suh, Hong-Won (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Kim, Jin-Kyu (Institute of Natural Medicine, Hallym University) ;
  • Lee, Jin-Koo (Institute of Natural Medicine, Hallym University) ;
  • Lim, Soon-Sung (Institute of Natural Medicine, Hallym University)
  • 투고 : 2010.06.30
  • 심사 : 2010.08.05
  • 발행 : 2010.08.30
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초록

In the present study, the antinociceptive profiles of Viola tricolor L. (V. tricolor L.) extract were examined in ICR mice. V. tricolor L. extract administered orally (200mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, V. tricolor L. extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 ${\mu}g$) was diminished by V. tricolor L. extract. Intraperitoneal (i.p.) pretreatment with yohimbine (${\alpha}_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by V. tricolor L. extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by V. tricolor L. extract in the writhing test. Our results suggest that V. tricolor L. extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of V. tricolor L. extract may be mediated by ${\alpha}_2$-adrenergic receptor, but not opioidergic and serotonergic receptors.

키워드

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