Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Image Fusion of Lymphoscintigraphy and Real images for Sentinel Lymph Node Biopsy in Breast Cancer Patients

유방암 환자의 감시림프절 생검을 위한 림포신티그라피와 실사영상의 합성

  • Jeong, Chang-Bu (Biomedical Engineering Branch, Division of Basic & Applied Sciences, National Cancer Center) ;
  • Kim, Kwang-Gi (Biomedical Engineering Branch, Division of Basic & Applied Sciences, National Cancer Center) ;
  • Kim, Tae-Sung (Department of Nuclear Medicine and Research Institute, National Cancer Center) ;
  • Kim, Seok-Ki (Department of Nuclear Medicine and Research Institute, National Cancer Center)
  • 정창부 (국립암센터 기초실용화연구부 의공학연구과) ;
  • 김광기 (국립암센터 기초실용화연구부 의공학연구과) ;
  • 김태성 (국립암센터 진단검사센터 핵의학과) ;
  • 김석기 (국립암센터 진단검사센터 핵의학과)
  • Received : 2010.10.08
  • Accepted : 2010.04.06
  • Published : 2010.04.30
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Abstract

This paper presents a method that registers a lymphoscintigraphy to the real image captured by a CMOS camera, which helps surgeons to easily and precisely detect sentinel lymph nodes for sentinel lymph node biopsy in breast cancer patients. The proposed method consists of two steps: pre-matching and image registration. In the first step, we localize fiducial markers in a lymphoscintigraphy and a real image of a four quadrant bar phantom by using image processing techniques, and then determines perspective transformation parameters by matching with the corresponding marker points. In the second step, we register a lymphoscintigraphy to a real images of patients by using the perspective transformation of pre-matching. To examine the accuracy of the proposed method, we conducted an experiment with a chest mock-up with radioactive markers. As a result, the euclidean distance between corresponding markers was less than 3mm. In conclusion, the present method can be used to accurately align lymphoscintigraphy and real images of patients without attached markers to patients, and then provide useful anatomical information on sentinel lymph node biopsy.

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References

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