한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제27권2호
  • /
  • Pages.194-197
  • /
  • 2010
  • /
  • 1598-298X(pISSN)
  • /
  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

마장마술마에서 발생한 만성폐쇄성폐질환 증례

Chronic Obstructive Pulmonary Disease in a Dressage Horse

  • Jeong, Hyo-Hoon (College of Veterinary Medicine, Kyungpook National University) ;
  • Ahn, Kei-Myung (Korea Racing Authority) ;
  • Kim, A-Ram (Korea Racing Authority) ;
  • Roh, Ha-Jung (Infectious Disease Department, College of Veterinary Medicine, University of Georgia) ;
  • Oh, Tae-Ho (College of Veterinary Medicine, Kyungpook National University)
  • 심사 : 2010.04.05
  • 발행 : 2010.04.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

14세의 거세 마장마술마가 기침, 빈호흡, 점액농성의 비루를 호소하여 한국마사회 말보건원 동물병원에 내원하였다. 일반적인 광범위 항생제 치료를 3주간 실시하였으나 임상증상은 오히려 악화되었다. 이후 환자는 심한 기침과 점액농성의 비루, 빈호흡을 동반한 노력성 호흡, 운동능력저하 등의 임상증상과 기관세척액세포검사에서 심한 호중구성 염증이 관찰되어 만성폐쇄성폐질환으로 진단되었다. 마방 내 공기정화 노력과 병행한 3주간의 전신 글루코콜티코이드 치료를 실시한 결과 치료 후 임상증상이 현저히 개선되었다. 본 증례는 국내 말에서 다발하는 만성호흡기질환 중비감염성염증인 만성폐색성폐질환의 존재 가능성을 시사하였다. 향후 질병 발생 예방을 위해 말 사육 환경 내 존재하는 항원의 조사와 질병 발생율 조사가 필요할 것으로 판단된다.

A 14-year-old gelded dressage horse weighing 500 kg was presented to the Equine Medical Center of the Seoul Racecourse of Korea Racing Authority (KRA) due to coughing and mucopurulent nasal discharge. The horse was initiated with empirical antibiotic in the first place. However, the clinical signs did not improve but were rather exacerbated even after 3 weeks of therapy. Extensive diagnostic procedures including transtracheal wash (TTW) fluid cytology were undertaken. The localized wheezes and crackles were auscultated and an increase in the amount of mucopurulent exudate in trachea was observed at endoscopy. Infiltration of neutrophils was observed in the TTW fluid cytology implying chronic obstructive pulmonary disease (COPD). Therefore, the systemic glucocorticoid therapy was to be given for 3 weeks with improved ventilation provided at the same time. The respiratory symptoms started to improve in 7 days of therapy and were fully resolved by when the therapy was terminated. The horse is clinically normal now and being monitored for development of any signs of chronic obstructive pulmonary disease.

키워드

참고문헌

  1. Art T, Duvivier DH, Votion D, Anciaux N, Vandenput S, Bayly WM, Lekeux P. Does an acute COPD crisis modify the cardiorespiratory and ventilatory adjustments to exercise in horses? J Appl Physiol 1998; 84: 845-852. https://doi.org/10.1152/jappl.1998.84.3.845
  2. Bracher V, Von Fellenberg R, Winder CN, Gruenig G, Hermann M, Kraehenmann A. An investigation of the incidence of chronic obstructive pulmonary disease (COPD) in random populations of Swiss horses. Equine Vet J 1991; 23: 136-141. https://doi.org/10.1111/j.2042-3306.1991.tb02738.x
  3. Clarke AF, Madelin T. Technique for assessing respiratory health hazards from hay and other source materials. Equine Vet J 1987; 19: 442-447. https://doi.org/10.1111/j.2042-3306.1987.tb02639.x
  4. Cook WR. Chronic bronchitis and alveolar emphysema in the horse. Vet Rec 1976; 99: 448-451. https://doi.org/10.1136/vr.99.23.448
  5. Couetil LL, Rosenthal FS, DeNicola DB, Chilcoat CD. Clinical signs, evaluation of bronchoalveolar lavage fluid, and assessment of pulmonary function in horses with inflammatory respiratory disease. Am J Vet Res 2001; 62: 538-546. https://doi.org/10.2460/ajvr.2001.62.538
  6. Cunningham FM, Dunkel B. Equine recurrent airway obstruction and insect bite hypersensitivity: Understanding the diseases and uncovering possible new therapeutic approaches. Vet J 2008; 177: 334-344. https://doi.org/10.1016/j.tvjl.2007.10.005
  7. Derksen FJ, Robinson NE, Armstrong PJ, Stick JA, Slocombe RF. Airway reactivity in ponies with recurrent airway obstruction (heaves). J Appl Physiol 1985; 58: 598-604. https://doi.org/10.1063/1.335669
  8. Derksen FJ, Robinson NE, Scott JS, Stick JA. Aerosolized Micropolyspora faeni antigen as a cause of pulmonary dysfunction in ponies with recurrent airway obstruction (heaves). Am J Vet Res 1998; 49: 933-938.
  9. Freeman KP, Roszel JF, McClure JM, Mannsman R, Patton PE, Naile S. A review of cytological specimens from horses with and without clinical signs of respiratory disease. Equine Vet J 1993; 25: 523-526. https://doi.org/10.1111/j.2042-3306.1993.tb03006.x
  10. Gillespie JR, Tyler WS. Chronic alveolar emphysema in the horse. Adv Vet Sci Comp Med 1969; 13: 59-99.
  11. Mair TS. Changing concepts of COPD. Equine Vet J 1995; 27: 402-403. https://doi.org/10.1111/j.2042-3306.1995.tb04417.x
  12. Marinkovic D, Aleksic-Kovacevic S, Plamenac P. Cellular Basis of Chronic Obstructive Pulmonary Disease in Horses. Int Rev Cytol 2007; 257: 213-247. https://doi.org/10.1016/S0074-7696(07)57006-3
  13. McPherson EA, Lawson GH, Murphy JR, Nicholson JM, Fraser JA, Breeze RG, Pirie HM. Chronic obstructive pulmonary disease (COPD): identification of affected horses. Equine Vet J 1978; 10: 47-53. https://doi.org/10.1111/j.2042-3306.1978.tb02215.x
  14. Naylor JM, Clark EG, Clayton HM. Chronic obstructive pulmonary disease; Usefulness of clinical signs, bronchoalveolar lavage, and lung biopsy as diagnostic and prognostic aids. Can Vet J 1992; 33: 591-598.
  15. Reed SM, Bayly WM, Sellon DC. Equine Internal Medicine 2nd ed. St Louis: WB Saunders. 1998: 142-353.
  16. Robinson NE, Sorenson PR. Pathophysiology of airway obstruction in horses: a review. J Am Vet Med Assoc 1978; 172: 299-303.
  17. Tesarowski DB, Viel L, McDonel WN. Pulmonary function measurements during repeated environmental challenge of horses with recurrent airway obstructions (heaves). Am J Vet Res 1996; 57: 1214-1219.
  18. Viel L. Small airway disease as a vanguard for chronic obstructive pulmonary disease. Vet Clin North Am Equine Pract 1997; 13: 549-560.
  19. Ward MP, Couetil LL. Climatic and aeroallergen risk factors for chronic obstructive pulmonary disease in horses. Am J Vet Res 2005; 66: 818-824. https://doi.org/10.2460/ajvr.2005.66.818