Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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Effect of Microcurrent Therapy on Interleukin-6 Expression in Adjuvant Induced Rheumatoid Arthritis Rat Model

미세전류치료가 아주반트 유도 류마티스관절염 유발 흰쥐의 인터루킨-6 발현에 미치는 영향

  • Lee, Hyun-Min (Department of Physical Therapy, Honam University) ;
  • Lee, Sang-Yeol (Department of Physical Therapy, Gimhae College) ;
  • Chang, Jong-Sung (Department of Physical Therapy, Yeungnam College of Science & Technology) ;
  • Lee, Myoung-Hee (Department of Physical Therapy, Daegu Health College) ;
  • Kang, Jong-Ho (Department of Physical Therapy, Nambu University)
  • 이현민 (호남대학교 물리치료학과) ;
  • 이상열 (김해대학 물리치료과) ;
  • 장종성 (영남이공대학 물리치료과) ;
  • 이명희 (대구보건대학 물리치료과) ;
  • 강종호 (남부대학교 물리치료학과)
  • Received : 2010.09.06
  • Accepted : 2010.11.11
  • Published : 2010.11.30
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Abstract

연구목적 : 미세전류 자극이 아주반트로 류마티스 관절염을 유발한 실험동물의 염증반응과 통증에 미치는 효과를 알아보기 위하여 실험동물의 발허리발가락관절내 염증반응 정도를 나타내는 인터루킨-6(interleukin-6)의 발현과 핫플레이트(hot plate)를 이용한 발도피지연시를 측정하여 미세전류의 효과에 대하여 알아보고자 하는데 목적이 있다. 연구방법 : 실험동물은 무작위로 대조군(n=18)과 미세전류를 적용한 실험군(n=18)으로 구분하였고, 각 군당 6마리씩 1일군, 7일군, 14일군으로 배정하였다. 류마티스 관절염 유발후 1일, 7일, 14일에 모든 실험동물의 열통각 역치를 나타내는 발도피지연시와 발허리발가락관절내 인터루킨-6의 발현정도를 측정하였다. 각 집단 내의 기간에 따른 발도피지연시와 인터루킨-6의 면역반응성은 일원배치 분산분석을 실시하였고, 사후분석으로는 Duncan의 다중범위검정을 실시하였다. 실험군과 대조군을 비교하기 위하여 독립표본 t-test를 실시하였다. 연구결과 : 실험결과는 다음과 같다. 1) 아주반트 주사 1일후, 실험군과 대조군에서 인터루킨-6 면역반응성과 발도피지연시는 비슷한 양상을 보였다. 2) 인터루킨-6 면역반응성은 아주반트 주사 7일, 14일 후 대조군이 실험군보다 유의하게 증가되었다(p<.05). 3) 발도피지연시는 아주반트 주사 7일, 14일 후 실험군이 대조군보다 유의하게 증가되었다(p<.05). 결론 : 이상의 결과로부터, 미세전류 자극이 아주반트로 유발된 류마티스관절염 모델에서 활액 조직내 염증반응을 감소시키고 열통각역치는 증가되는 것을 알 수 있었다.

Keywords

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