Journal of Radiation Industry (방사선산업학회지)
- Volume 4 Issue 1
- /
- Pages.1-6
- /
- 2010
- /
- 1976-2402(pISSN)
Synthesis of 18F Labelled Isoquinoline Salt for PET Imaging
PET 영상용 18F 표지 Isoquinolinium Salt의 합성
- Kim, Hee Jung (Korea Atomic Energy Research Institute) ;
- Kim, Dong Yeon (Department of Chemistry, Dongguk University) ;
- Kim, In Jong (Korea Atomic Energy Research Institute) ;
-
Park, Jeong Hoon
(Korea Atomic Energy Research Institute)
;
- Lee, Heung Nae (Korea Atomic Energy Research Institute) ;
- Kim, Sang Wook (Korea Atomic Energy Research Institute) ;
-
Hur, Min Goo
(Korea Atomic Energy Research Institute)
;
- Choi, Sang Moo (Korea Atomic Energy Research Institute) ;
-
Yang, Seung Dae
(Korea Atomic Energy Research Institute)
;
-
Yu, Kook Hyun
(Department of Chemistry, Dongguk University)
- 김희정 (한국원자력연구원) ;
- 김동연 (동국대학교 화학과) ;
- 김인종 (한국원자력연구원) ;
-
박정훈
(한국원자력연구원)
;
- 이홍래 (한국원자력연구원) ;
- 김상욱 (한국원자력연구원) ;
-
허민구
(한국원자력연구원)
;
- 최상무 (한국원자력연구원) ;
-
양승대
(한국원자력연구원)
;
-
유국현
(동국대학교 화학과)
- Received : 2009.12.24
- Accepted : 2010.01.07
- Published : 2010.03.30
Abstract
The purpose of this study is to synthesize the radio fluorine labelled isoquinoline salt derivative as new radiopharmaceutical for imaging tumors using positron emission tomography (PET). The planarity of isoquinoline allows to inhibit topoisomerase or intercalate between adjacent DNA base pairs, which result in producing double strand breaks in the DNA and a cell death. Therefore, the isoquinoline has seemed to have a potential anticancer activity. In order to obtain 2-(5-[