Animal cells and systems

  • 제14권1호
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  • Pages.11-15
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  • 2010
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  • 1976-8354(pISSN)
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  • 2151-2485(eISSN)
한국통합생물학회 (The Korean Society for Integrative Biology)
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Assessment of long-term working memory by a delayed nonmatch-to-place task using a T-maze

  • Kim, Jung-Eun (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Choi, Jun-Hyeok (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Kaang, Bong-Kiun (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University)
  • 투고 : 2009.10.05
  • 발행 : 2010.03.31
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초록

Long-term working memory (LTWM) is a subdivision concept of working memory and indicates the enhancement of performance in a working memory task. LTWM has been shown in humans who have been engaged in a specific task requiring working memory over a long time. However, there is very little understanding of the exact mechanism of LTWM because of limitations of experimental methods in human studies. We have modified the standard T-maze task, which is used to test working memory in mice, to demonstrate LTWM in an animal model. We observed an enhancement of performance by repeated experience with the same working memory load in mice, which can be regarded as an LTWM. This effect seems to depend on the condition wherein a delay was given. This task may be a good experimental protocol to assess LTWM in animal studies.

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피인용 문헌

  1. Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze vol.343, pp.None, 2018, https://doi.org/10.1016/j.bbr.2018.01.020