대한수의학회지 (Korean Journal of Veterinary Research)

  • 제50권4호
  • /
  • Pages.279-284
  • /
  • 2010
  • /
  • 2466-1384(pISSN)
  • /
  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지

Florfenicol-amoxicillin 혹은 florfenicol-cefuroxime 병용투여시 어류 병원성 세균에 대한 약역학

Pharmacodynamics of florfenicol alone and in combination with amoxicillin or cefuroxime against pathogenic bacteria of fish origin

  • Lee, Eun-Mi (College of veterinary Medicine, Kyungpook National University) ;
  • Choi, Myung-Jin (College of veterinary Medicine, Kyungpook National University) ;
  • Lee, Seung-Jin (College of veterinary Medicine, Kyungpook National University) ;
  • Park, Seung-Chun (College of veterinary Medicine, Kyungpook National University)
  • 심사 : 2010.09.07
  • 발행 : 2010.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Combination therapy of antibiotics is leading to improved efficacy or safety profiles with decrease emergence of bacterial resistance. Because of this benefit, many of antibacterial combinations have been used in veterinary practice for the past few decades. The purpose of this study was to examine the in vitro activity of an amoxicillin alone and in combination with other antibiotics against pathogenic bacteria of fish origin. Based on the fractional inhibitory concentration (FIC) index (FIC $$\leq_-$$ 0.5), a synergistic interaction was shown in combination of florfenicol with amoxicillin or cefuroxime. The combination of florfenicol and amoxillin showed higher antibacterial activity than that of florfenicol and cefuroxime. Ratio of amoxicillin and florfenicol in combination was 1 : 1, which showed the antibacterial activity against bacterial isolates of fish as compared with other ratios. A synergetic effect of the combination (amoxicillin and florfenicol) was further confirmed in the time-kill curve study. The study showed a better in vitro antibacterial activity of a 1 : 1 combination of amoxicillin and florfenicol than the individual antibacterial against bacterial isolates of fish. In conclusion, the combination of florfenicol and amoxicillin may serve as a potential antibacterial therapy in fishes infected pathogenic bacteria.

키워드

참고문헌

  1. 국립수의과학검역원. 동물용의약품의 안전사용기준. 국립수의과학검원고시 제2007-25호. 국립수의과학검역원, 안양, 2008.
  2. 국주희, 송영미, 배민석, 고명진, 유명상, 안은숙, 박은희, 조명식, 강길진. 식육중 항생제 florfenicol의 분석. 한국식품위생안전성학회지 2008, 23, 319-323.
  3. 김민규, 윤효인, 박승춘. 병원성미생물에 대한 Enrofloxacin과 Colistin의 배합비율에 따른 항균작용과 균의 사멸속도. 한국임상수의학회지 1997, 14, 215-222.
  4. 김홍태, 정경태, 이동수, 이근우. 유통되는 쇠고기에서 분리한 대장균의 항생제 내성 조사.연구 (2). 한국가축위생학회지 2009, 32, 93-102.
  5. 손성완, 이광직, 이명헌, 장환, 정갑수, 위성환, 이주호, 강문일. 국내 동물용 의약품의 사용과 품질관리현황. 한국수의공중보건학회지 2006, 30, 89-96.
  6. 오종석, 안태휴. 녹농균에 대한 Aminoglycoside계와 Cephalosporin계의 병합작용. 대한미생물학회지 1986, 21, 375-380.
  7. 정승희, 김진우. 병용 항균제의 어류질병 세균에 대한 시험관내 항균활성. 한국어병학회지 2000, 13, 45-51.
  8. 정현도, 전세규. 항생제 사용과 세균성 어류질병의 치료. 한국어병학회지 1992, 5, 37-48.
  9. 허정호, 정명호, 조명희, 김국헌, 이국천, 김재훈, 정태성. 경남 남부지역 양식어류 질병에서 항생제 감수성에 관한 연구. 대한임상수의학회지 2002, 19, 19-22.
  10. Andrews JM, Boswell FJ, Wise R. Evaluation of the Oxoid Aura image system for measuring zones of inhibition with the disc diffusion technique. J Antimicrob Chemother 2000, 46, 535-540. https://doi.org/10.1093/jac/46.4.535
  11. Bonapace CR, Friedrich LV, Bosso JA, White RL. Determination of antibiotic effect in an in vitro pharmacodynamic model: comparison with an established animal model of infection. Antimicrob Agents Chemother 2002, 46, 3574-3579. https://doi.org/10.1128/AAC.46.11.3574-3579.2002
  12. Bouanchaud DH. In-vitro and in-vivo synergic activity and fractional inhibitory concentration (FIC) of the components of a semisynthetic streptogramin, RP 59500. J Antimicrob Chemother 1992, 30, 95-99. https://doi.org/10.1093/jac/30.suppl_A.95
  13. Honeybourne D, Andrews JM, Cunningham B, Jevons G, Wise R. The concentrations of clinafloxacin in alveolar macrophages, epithelial lining fluid, bronchial mucosa and serum after administration of single 200mg oral doses to patients undergoing fibre-optic bronchoscopy. J Antimicrob Chemother 1999, 43, 153-155. https://doi.org/10.1093/jac/43.1.153
  14. Odland BA, Erwin ME, Jones RN. Quality control guidelines for disk diffusion and broth microdilution antimicrobial susceptibility tests with seven drugs for veterinary applications. J Clin Microbiol 2000, 38, 453-455.
  15. Park BK, Lim JH, Kim MS, Hwang YH, Yun HI. Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in dogs. Res Vet Sci 2008, 84, 85-89. https://doi.org/10.1016/j.rvsc.2007.04.001