Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Anti-obesity Activity of Extract from Saussurea lappa

목향 추출물의 항비만 활성 효과

  • Yoon, Tae-Sook (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Sung, Yoon-Young (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Jang, Ja-Young (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Yang, Won-Kyung (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Ji, Yun-Ui (Center of Herbal Resources Research, Korea Institute of Oriental Medicine) ;
  • Kim, Ho-Kyoung (Center of Herbal Resources Research, Korea Institute of Oriental Medicine)
  • 윤태숙 (한국한의학연구원 한약자원연구센터) ;
  • 성윤영 (한국한의학연구원 한약자원연구센터) ;
  • 장자영 (한국한의학연구원 한약자원연구센터) ;
  • 양원경 (한국한의학연구원 한약자원연구센터) ;
  • 지윤의 (한국한의학연구원 한약자원연구센터) ;
  • 김호경 (한국한의학연구원 한약자원연구센터)
  • Received : 2010.03.10
  • Accepted : 2010.05.28
  • Published : 2010.06.30
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Abstract

Obesity has become one of the main public health problems. Saussurea lappa (Asteraceae), syn Aucklandia lappa and Saussurea costus, is a well-known herbal medicine that has been used for treating various ailments, such as inflammatory and gastrointestinal diseases. The present study examined the anti-obesity effect of S. lappa extract (SLE) in 3T3-L1 adipocytes and high fat diet (HFD)-induced obese mouse model. SLE significantly inhibited the differentiation from preadipocytes to adipocytes of cultured 3T3-L1 in dose-dependent manner. In addition, SLE significantly decreased the body weight gain and the food efficiency ratio of mice fed HFD during 9 weeks. Further study must be performed for the pharmacological mechanism and safety of SLE as well as the identification of active compound in SLE. Our results revealed that S. lappa suppresses the adipogenesis in cultured cells and the obesity in rodent models. Therefore, S. lappa may be useful toward the development of new potent anti-obesity drugs.

Keywords

References

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