양릉천 인진 약침이 흰쥐의 고지혈증에 미치는 영향

A Study on the Effect of Herbal-acupuncture with Artemisiae Capillaris Herba at GB34 on Hyperlipidemia in Rat

  • 이정태 (대전대학교 한의과대학 경락경혈학교실) ;
  • 이병렬 (부산대학교 한의학전문대학원 임상의학부) ;
  • 양기영 (부산대학교 한의학전문대학원 임상의학부) ;
  • 이현 (대전대학교 한의과대학 침구학교실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Lee, Jung-Tae (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University) ;
  • Lee, Byung-Ryul (Division of Clinical Medicine, School of Korean Medicine, Pusan National University) ;
  • Yang, Gi-Young (Division of Clinical Medicine, School of Korean Medicine, Pusan National University) ;
  • Lee, Hyun (Dept. of Acupuncture & Moxibustion, College of Oriental Medicine, Daejeon University) ;
  • Yim, Yun-Kyoung (Dept. of Meridian & Acupoint, College of Oriental Medicine, Daejeon University)
  • 투고 : 2010.03.04
  • 심사 : 2010.03.23
  • 발행 : 2010.03.27

초록

Objective & Methods: The purpose of this study is to investigate the effects of Artemisiae Capillaris Herba herbal-acupuncture (ACH-HA) at GB34 (Yangleungchean) on hyperlipidemia induced with alloxan injection and high fat diet in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, liver, as well as the histological changes of liver and aorta. Results: 1. ACH-HA solution increased the DPPH radical scavenging activity in rat liver cells. 2. ACH-HA at GB34 significantly decreased the levels of serum total cholesterol, low-density lipoprotein (LDL)-cholesterol, free cholesterol and atherogenic index (AI), while significantly increased the ratios of high-density lipoprotein (HDL)/total cholesterol and phospholipid/total cholesterol in hyperlipidemic rats. 3. ACH-HA at GB34 significantly decreased serum aspartate aminotransferase (AST) level in hyperlipidemic rats. 4. ACH-HA at GB34 significantly increased hepatic glutathione (GSH) activity in hyperlipidemic rats. Conclusion: From the above results, it is suggested that ACH-HA at GB34 may have therapeutic and preventive effects on hyperlipidemia.

키워드

참고문헌

  1. 통계청. 2007년 사망원인통계결과. 대전 : 통계청. 2007 : 2.
  2. 박정현, 조문숙. 고콜레스테롤혈증을 가진 성인에서 진단, 평가 및 치료를 위한 NCEP-ATPIII 지침. 한국지질동맥경화학회지. 2001 ; 11(4) : 420-9.
  3. Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. 해리슨 내과학 1권, 서울 : MIP. 2003 : 1418.
  4. 강윤호, 방혜정, 탁의수, 홍율희. 고지혈증에 대한 한의학적 고찰. 동서의학. 1995 ; 20(1) : 25-36.
  5. 대한약침학회 편저. 약침요법시술지침서. 서울 : 대한약침학회. 2000 : 13-6.
  6. 전국한의과대학 본초학교수. 본초학. 서울 : 영림사. 2000 : 328-9.
  7. 임윤경, 김태한, 정연탁. 대학경락경혈학 실습. 대전 : 초락당. 2009 : 1024-34, 137-41.
  8. 김유창, 김승모, 최홍식, 박지하, 서부일. 인진호탕(茵蔯蒿湯)과 한인진호탕(韓茵蔯 蒿湯)이 알코올 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향. 대한본초학회지. 2003 ; 21(3) : 47-54.
  9. 김주곤, 서부일, 최선미, 최홍식. 한인진호탕(韓茵蔯蒿湯)이 알코올 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향. 대한본초학회지. 2005 ; 20(1) : 9-17.
  10. 함인혜 , 정성웅, 이경진, 박규하, 최호영. 인진호(茵蔯蒿)와 한인진(韓茵蔯)이 Triton WR-1339로 유도된 고지혈증 흰쥐에 미치는 영향. 대한본초학회지. 2005 ; 20(1) : 45-52.
  11. Xie W, Wang W, Su H, Xing D, Cai G, Du L. Hypolipidemic mechanisms of Ananas comosus L. leaves in mice: different from fibrates but similar to statins. Journal of Pharmacological Sciences. 2007 ; 103(3) : 267-74. https://doi.org/10.1254/jphs.FP0061244
  12. 고형균. 생쥐에서의 골도분촌에 의한 상응혈위. 대한침구학회지. 2001 ; 18(6) : 225-31.
  13. Bansal VS, Hattori H, Orihel D, Kanfer JN. Neurochem Res.. Distribution of selected phospholipid modifying enzymes in rat brain microsomal subfracions prepared by density grradient zonal rotor centrifugation. 1985 ; 10(4) : 439-51. https://doi.org/10.1007/BF00964649
  14. Martin MJ. Serum cholesterol, blood pressure, and mortality : implicaions from a cohort of 361,662 men. Lancet. 1986 ; 2 : 933-6.
  15. Schuster H, Fox JC.. Investigating cardiovascular risk reduction the Rosuvastatin GALAXY Programme. Expert Opin Pharmacother. 2004 ; 5(5) : 1187-200. https://doi.org/10.1517/14656566.5.5.1187
  16. Jones PH., Davidson MH., Stein EA., Bays HE., Mcjenney JM., Miller E., et al. STELLAR Study Group. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial). Am J Cardiol. 2003 ; 92(2) : 152-60. https://doi.org/10.1016/S0002-9149(03)00530-7
  17. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lowerthan-average cholesterol concentration, in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet. 2003 ; 361(9364) : 1149-58. https://doi.org/10.1016/S0140-6736(03)12948-0
  18. 이상학. 이상지질혈증의 진단 및 치료. 서울 : 대한내과학회지. 2008 : 358-62.
  19. 성지동, 김상현, 김영대, 백상홍, 안영근, 임도선 등. 국내 10개 대학병원의 관동맥 질환자의 고콜레스테롤증 치료 현황. 내과학회지. 2005 ; 69(4) : 371-9.
  20. 전국한의과대학 간계내과학 교수. 간계 내과학. 서울 : 동양의학연구원출판부. 1995 : 214-5.
  21. 김창민, 신민교, 안덕균, 이경순. 중약대사전 , 서울 : 정담출판사. 2004 : 3500-3.
  22. 대한비만학회. 임상비만학. 서울 : 고려의학. 2008 : 281-3.
  23. DeWitt S. Goodman, Robert P. Noble. Turnover of plasma cholesterol in man, J Clin Invest. 1968 ; 47(2) : 231-41. https://doi.org/10.1172/JCI105719
  24. Smith, E.B.. The relationship between plasma and tissue lipid in human atherosclerosis. Adv. Lipid Res. 1974 ; 12 : 1-49.
  25. C.J. Fielding, P.E. Fielding. Molecular physiology of reverse cholesterol transport. Journal of Lipid Research. 1995 ; 36 : 211-28.
  26. 한국브리태니커회사단체. 브리태니커세계대백과사전. 서울 : 한국브리태니커회사. 1992 : 제18권 296, 제21권 591.
  27. 이삼열. 임상검사법개요. 서울 : 연세대학교출판부. 2000 : 281, 310, 405.
  28. Kim, K.H. The clinical application of the results of the test. Seoul : Ko Moon Sa. 1980 : 164-76.
  29. Steinberg D. Oxidative modification of LDL and atherogenesis. Circulation. 1997 ; 95 : 1062-71. https://doi.org/10.1161/01.CIR.95.4.1062
  30. Treasure C. B., Larry Klein J., Weintraub W.S., Talley D., Stillabower M. E., Kosinski A. S., et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N. Engl. J. Med. 1995 ; 332 : 481-7. https://doi.org/10.1056/NEJM199502233320801
  31. Anderson T. J., Meredith I. T., Yeung A. C., Frei B., Selwyn A. P., Ganz P. The effect of cholesterol-lowering and antioxidant therapy on endotheliumdependent coronary vasomotion. N. Engl. J. Med. 1995 ; 332 : 488-93. https://doi.org/10.1056/NEJM199502233320802
  32. Ozturk O., Gumuslu S. Changes in glucose-6-phosphate dehydrogenase, copper, zinc-superoxide dismutase and catalase activities, glutathione and its metabolizing enzymes, and lipid peroxidation in rat erythrocytes with age. Experimental gerontology. 2004 ; 39(2) : 211-6. https://doi.org/10.1016/j.exger.2003.10.015
  33. 金聖勳, 曺永周. 高麗人蔘.高麗紅蔘 및 total saponin의 抗酸化作用. 東醫病理學會誌. 1998 ; 12(1) : 72-81.