동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제24권2호
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  • Pages.302-309
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  • 2010
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

아토피 피부염 유사 NC/Nga 마우스 모델에서 아토베리의 항산화 및 항염증효과

Antioxidant and Anti-inflammatory Effects of Atoberry in Atopic Dermatitis-like NC/Nga Mouse Model

  • 목지예 (전주대학교 아토피.건강전문연구소) ;
  • 박광현 (전북대학교 의학전문대학원 생화학교실) ;
  • 유철 (전북대학교 고창복분자진흥사업단) ;
  • 조정근 (전주대학교 대체의학대학) ;
  • 장선일 (전주대학교 아토피.건강전문연구소)
  • Mok, Ji-Ye (Jeonju University Atopy & Health Research Institute) ;
  • Park, Kwang-Hyun (Department of Biochemistry, Chonbuk National University Medical School) ;
  • Ryu, Cheol (Gochang Black Raspberry Industry Promotion Agency, Chonbuk National University Medical School) ;
  • Cho, Jung-Keun (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University) ;
  • Jang, Seon-Il (Jeonju University Atopy & Health Research Institute)
  • 투고 : 2010.03.20
  • 심사 : 2010.04.13
  • 발행 : 2010.04.25
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초록

Oxidative stress has been implicated in cutaneous damage in various inflammatory skin diseases, including atopic dermatitis (AD). Atoberry is the herb medicine extract which is composed with Spirodelae Herba, Xanthii Fructus, Houttuyniae Herba, Taraxaci Herba, Retinervus Luffae Fructus, Platycodi Radix, and Scutellariae Radix. In this study, we investigated the antioxidant and anti-inflammatory effects of Atoberry in AD-like skin lesion NC/Nga mice. Murine AD-like skin lesions were made by painting Dermatophagoides farinse (Df) extract. Atoberry significantly increased electron donating ability (DPPH), nitrite scavenging (NO) and superoxide dismutase (SOD) activities in dose dependant. Topically applied Atoberry significantly reduced clinical severity score, ear thickness and histological grade in AD-like skin lesion NC/Nga mice. In addition, the serum levels of IgE, NO and prostaglandin E2 were significantly reduced by Atoberry. Futhermore, skin tissue levels of SOD, catalase and glutathione peroxidase (GPx) were significantly reduced by Atoberry. These results demonstrate that topical application of Atoberry may be improve the AD-like skin lesion by antioxidant and anti-inflammatory effects.

키워드

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