Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지
DOI QR코드

DOI QR Code

Analysis of Anti-Allergic Activities by Extracts from Persimmon Sap-Stained Rayon and Cotton Fabrics

감물염색 직물의 추출물에 의한 항알러지 활성의 분석

  • Lee, Sang-Han (Food & Bio-Industry Research Institute, and Department of Food Science & Biotechnology, Kyungpook National University)
  • 이상한 (경북대학교 식품생물산업연구소 및 대학원 식품공학과)
  • Received : 2010.02.01
  • Accepted : 2010.03.16
  • Published : 2010.05.31
Download PDF
⟨ Previous Next ⟩

Abstract

Allergic dermatitis is one of the most prevalent diseases in young/juvenile children worldwide. In this research, extracts with persimmon sap-stained fabrics (rayon and cotton) exhibited an elevation in $CD4^+$ cell numbers. MMP-2 and MMP-9 expressions by Hematoxylin-Eosin staining and immunohistochemistry revealed that the expressions were decreased by addition of the extracts. The present results collectively suggest that the active ingredients of persimmon sap-stained fabrics play an important role in inhibition of DNFB-induced-atopic symptoms in vivo.

알러지성 피부염은 현재 영유아 4인 중 1명이 발병할 정도로 심각한 질환으로 보고되어 있다. 본 연구는 청도감물염색을 한 직물 2종(인견과 면)의 물 추출물이 알러지성 피부염 유도 동물모델에서 피부의 표피에 면역관련의 세포의 수를 감소시킴을 H&E 염색으로 확인하였으며, 알러지성 피부염에 직접 관련이 있는 분자표적인 $CD4^+$ cell의 분포를 비교하여 본 결과, 유의성 있게 항알러지성 피부염 활성을 보유하고 있는 것을 확인하였다. MMP-2와 MMP-9의 면역조직화학적 분석을 수행한 결과, 이들의 발현도 감소함으로 감물염색에 사용된 감의 유용성분 예를 들면 폴리페놀 성분 등이 알러지성 피부염의 억제활성에 관련이 있을 것으로 추정된다.

Keywords

References

  1. An, B. J., J. H. Kwak, J. M. Park, J. Y. Lee, T. S. Park, J. T. Lee, J. H. Son, C. Jo, and M. W. Byun. 2005. Inhibition of enzyme activities and the antiwrinkle effect of polyphenol isolated from the persimmon leaf (Diospyros kaki folium) on human skin. Dermatol. Surg. 31, 848-854.
  2. Celik, A. and S. Ercisli. 2008. Persimmon cv. Hachiya (Diospyros kaki Thunb.) fruit: some physical, chemical and nutritional properties. Int. J. Food Sci. Nutr. 59, 599-606. https://doi.org/10.1080/09637480701538221
  3. Dewanjee, S., A. K. Das, R. Sahu, and M. Gangopadhyay. 2009. Antidiabetic activity of Diospyros peregrina fruit: effect on hyperglycemia, hyperlipidemia and augmented oxidative stress in experimental type 2 diabetes. Food Chem. Toxicol. 47, 2679-2685. https://doi.org/10.1016/j.fct.2009.07.038
  4. FAO. 2001. FAOSTAT, FAO Statistical Databases (http://www.fao.org/inicio.htm).
  5. Glader, P., B. Eldh, S. Bozinovski, K. Andelid, M. Sjostrand, C. Malmhall, G. P. Anderson, G. C. Riise, I. Qvarfordt, and A. Linden. 2008. Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space. Eur. Respir. J. 32, 644-650. https://doi.org/10.1183/09031936.00121507
  6. Hazra, B., B. Kumar, S. Biswas, B. N. Pandey, and K. P. Mishra. Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation. Toxicol. Lett. 157, 109-117.
  7. Heo, J. C., J. R. Rho, T. H. Kim, S. Y. Kim, and S. H. Lee. 2008. An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers. Int. J. Mol. Med. 22, 763-768.
  8. Heo, J. C., S. W. Woo, M. A. Kweon, J. Y. Park, H. K. Lee, M. Son, J. R. Rho, and S. H. Lee. 2008. Aqueous extract of a seed from Helianthus annuus alleviates asthmatic symptoms in vivo. Int. J. Mol. Med. 21, 57-61.
  9. Hwang, Y. K., J. S. Chun, P. D. Yoo, J. Y. Ma, B. H. Hyun, S. U. Kim, K. T. Chang, and S. -H. Lee. 2004. Occlusal reduction of unilateral molars influences change of stress-related hormones in rats. Scand. J. Lab Animal Sci. 31, 73-77.
  10. Inagaki, N., N. Shiraishi, K. Igeta, T. Itoh, T. Chikumoto, M. Nagao, J. F. Kim, and H. Nagai. 2006. Inhibition of scratching behavior associated with allergic dermatitis in mice by tacrolimus, but not by dexamethasone. Eur. J. Pharmacol. 546, 189-196. https://doi.org/10.1016/j.ejphar.2006.07.019
  11. Ker, J. and T. V. Hartert. 2009. The atopic march: what's the evidence? Ann. Allergy Asthma Immunol. 103, 282-289. https://doi.org/10.1016/S1081-1206(10)60526-1
  12. Kikuchi, Y., T. Takai, M. Ota, T. Kato, K. Takeda, K. Mitsuishi, S. Ikeda, K. Okumura, and H. Ogawa. 2006. Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgEin mice immunized with recombinant major mite allergens or ovalbumin. Int. Arch. Allergy Immunol. 141, 322-330. https://doi.org/10.1159/000095458
  13. Kim, D. Y., S. Y. Ryu, J. E. Lim, Y. S. Lee, and J. Y. Ro. 2007. Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur. J. Pharmacol. 557, 76-86. https://doi.org/10.1016/j.ejphar.2006.11.027
  14. Kotani, M., M. Matsumoto, A. Fujita, S. Higa, W. Wang, M. Suemura, T. Kishimoto, and T. Tanaka, 2000. Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. Allergy Clin. Immunol. 106, 159-166. https://doi.org/10.1067/mai.2000.107194
  15. Lee, S. H., K. D. Moon, S. W. Woo, Y. R. Lee. 2006. Final Report of Inhibitory Effects of Persimmon Extracts on Immune Diseases (Atopy, Allergy) as a Natural Staining Biomaterial. CheongDo Agricultural Technology Services, pp. 1-102. CheongDo-Kun, Korea.
  16. Matsumoto, M., M. Kotani, A. Fujita, S. Higa, T. Kishimoto, M. Suemura, and T. Tanaka. 2002. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice,NC/Nga. Br. J. Dermatol. 146, 221-227. https://doi.org/10.1046/j.1365-2133.2002.04557.x
  17. Matsumoto, K., S. I. Yokoyama, and N. Gato. 2009. Bile acid-binding activity of young persimmon (Diospyros kaki) fruit and its hypolipidemic effect in mice. Phytother Res. 24, 205-210.
  18. Niyonsaba, F., I. Nagaoka, H. Ogawa, and K. Okumura. 2009. Multifunctional antimicrobial proteins and peptides: natural activators of immune systems. Curr. Pharm. Des. 15, 2393-2413. https://doi.org/10.2174/138161209788682271
  19. Ponikau, J. U., D. A. Sherris, G. M. Kephart, E. B. Kern, T. A. Gaffey, J. E. Tarara, and H. Kita. 2003. Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma? J. Allergy Clin. Immunol. 112, 877-882. https://doi.org/10.1016/j.jaci.2003.08.009
  20. Remacle, A. G., D. V. Rozanov, M. Fugere, R. Da, and A. Y. Strongin. 2006. Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP. Oncogene 25, 5648-5655. https://doi.org/10.1038/sj.onc.1209572
  21. Van Lint, P. and C. Libert. 2007. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J. Leukoc. Biol. 82, 1375-1381. https://doi.org/10.1189/jlb.0607338

Cited by

  1. Dyeing of Cotton Fabrics with Persimmon Extract Powder - Focused on Dyeability and Mechanical Properties Depending on Color Characteristics - vol.22, pp.5, 2013, https://doi.org/10.5934/kjhe.2013.22.5.461
  2. Effect of Color Developing by Xenon Irradiation on Cotton Fabrics Dyed with Persimmon Extract Powder Dye vol.25, pp.1, 2013, https://doi.org/10.5764/TCF.2013.25.1.56
  3. Research and Survey Gal-ot Product in Jeju vol.16, pp.4, 2014, https://doi.org/10.5805/SFTI.2014.16.4.520