생명과학회지 (Journal of Life Science)

  • 제20권5호
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  • Pages.691-696
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  • 2010
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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Streptozotocin으로 유발 된 당뇨 흰쥐에서 소당탕(消糖湯)의 항산화 효과

Antioxidative Effect of So-Dang-Tang in Streptozotocin-Induced Diabetic Rats

  • 정진기 (동국대학교 한의과대학 본초학교실) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Jung, Jin-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
  • 투고 : 2010.01.08
  • 심사 : 2010.04.19
  • 발행 : 2010.05.31
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초록

본 연구에서는 STZ로 당뇨병이 유발된 흰쥐의 간, 신장, 췌장 조직으로부터 소당탕(SDT)의 항산화 효과를 확인하여 다음과 같은 결과를 얻었다. 1. SDT의 투여는 간, 신장, 췌장 내 항산화효소인 SOD의 활성을 유의적으로 증가시켰다. 2. SDT의 투여는 간, 신장, 췌장 내 항산화물질인 GSH의 농도를 유의적으로 증가시켰다. 3. SDT의 투여는 간, 신장, 췌장 내 지질과산화 산물인 MDA의 농도를 유의적으로 감소시켰다. 이상의 결과로 볼 때 소당탕은 STZ로 유발된 당뇨병 흰쥐에서 항산화효소 활성과 항산화물질 생성을 증가시키고, 산화물질 생성을 억제함으로써 항산화 효과가 확인되었다.

In this study, we investigated the antioxidative effects of So-Dang-Tang (SDT) on streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (45 mg/kg body weight) into Sprague-Dawley rats. The SDT (200 mg/kg) and the reference drug, glibenclimide (1mg/kg), were orally administered once a day for 28 days in STZ-induced diabetic rats. The activity of antioxidant enzymes, including those of superoxide dismutase (SOD) and catalase, and the levels of glutathione (GSH) and production of malondialdehyde (MDA) were measured in the liver, kidney, and pancreas of diabetic rats. Treatment with SDT in STZ-induced diabetic rats significantly increased the activities of antioxidant enzymes and GSH levels in the liver, kidney, and pancreas when compared to those of the STZ-control group. SDT also significantly decreased lipid peroxidation product and MDA levels in STZ-induced diabetic rats. These results indicate that SDT has an antioxidative action in STZ-induced diabetic rats.

키워드

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