Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Hypoglycemic Effect of Complex of Chinese Traditional Herbs (CTH) and Macelignan in Type 2 Diabetic Animal Model

레이저 제2형 당뇨동물모델에서 macelignan과 한약제 열수 추출물의 병용효과

  • Yeo, Ji-Young (School of Korean Medicine, Pusan National University) ;
  • Cho, Soo-In (School of Korean Medicine, Pusan National University) ;
  • Jung, Myeong-Ho (School of Korean Medicine, Pusan National University)
  • 여지영 (부산대학교 한의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원) ;
  • 정명호 (부산대학교 한의학전문대학원)
  • Received : 2010.04.29
  • Accepted : 2010.06.21
  • Published : 2010.07.30
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Abstract

This study investigated the efficacy of macelignan and hot water with Chinese traditional herb (CTH) extract on altering severe diabetic conditions in C57BL/KsJ-db/db mice. Previously, the anti-diabetic effects of macelignan were partly reported as a PPAR $\alpha/\gamma$-dual agonist. Here, we futher studied whether a combination of macelignan and CTH had more beneficial effects or not. The macelignan and CTH compound significantly decreased fasting blood glucose and HbA1c compared to macelignan-treated mice, and also significantly improved postprandial glucose, insulin sensitivity, and plasma lipid profiles (FFA, and TG). On the other hand, insulin levels were not significantly changed compared to the diabetic control group. There were no significant changes in the concentrations of total cholesterol and HDL-cholesterol, but there were changes in HTR and AI. These results suggest that the macelignan and CTH compound ameliorates hyperglycemia and efficiently improves postprandial glucose, insulin sensitivity, and hyperlipidemia compared with macelignan in db/db mice. Moreover, the macelignan and CTH compound seems to be more potent in affecting diabetic complications than macelignan.

본 연구는 macelignan과 CTH를 제2형 당뇨병동물모델에 3주간 병용 투여하여 macelignan을 단독으로 투여했을 때보다 더 나은 효과가 있는지를 살펴 보았다. Macelignan과 CTH의 병용 투여는 공복혈당과 내당능을 비롯하여 혈중 free fatty acids, HTR, 그리고 AI에서는 macelignan 단독 투여군과 비교하여 유의적으로 나타나는 큰 차이를 발견할 수는 없었다. 그러나, HbA1c, insulin 민감도, 그리고 혈중 triglyceride 함량에서는 유의적인 변화를 보이며 효과가 있는 것으로 나타났다. 따라서, macelignan의 단독 투여보다 CTH를 병용 투여하는 것이 당뇨병 합병증을 예방하거나 개선시킬 수 있는 잠재력이 있을 것으로 판단된다. 이에 보다 명확하게 검증하기 위해 혈당 및 대사조절 기전연구를 위한 further study가 진행되어야 할 것으로 사료된다.

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