Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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The effect of platelet rich plasma in bone formation on implant installation in the tibia of beagle dogs

비글견 경골에서 임플란트 식립 시 혈소판 농축 혈장이 골형성에 미치는 영향

  • Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Insitutue, Chonnam National University) ;
  • Jung, Seung-Gon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Insitutue, Chonnam National University) ;
  • Shim, Kyung-Mi (Department of Radiology, Nambu University) ;
  • Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University) ;
  • Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Insitutue, Chonnam National University) ;
  • Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Insitutue, Chonnam National University) ;
  • Oh, Hee-Kyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Insitutue, Chonnam National University)
  • 국민석 (전남대학교 치의학전문대학원 구강악안면외과학교실, 치의학연구소) ;
  • 정승곤 (전남대학교 치의학전문대학원 구강악안면외과학교실, 치의학연구소) ;
  • 심경미 (남부대학교 방사선학과) ;
  • 강성수 (전남대학교 수의과대학 수의학과) ;
  • 박홍주 (전남대학교 치의학전문대학원 구강악안면외과학교실, 치의학연구소) ;
  • 유선열 (전남대학교 치의학전문대학원 구강악안면외과학교실, 치의학연구소) ;
  • 오희균 (전남대학교 치의학전문대학원 구강악안면외과학교실, 치의학연구소)
  • Received : 2010.03.04
  • Accepted : 2010.04.08
  • Published : 2010.04.30
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Abstract

Introduction: The purpose of this study is to evaluate the effect of platelet rich plasma in bone formation and osseointegration of implant installed in the bone marrow space. Materials and Methods: Five beagle dogs were used as experimental animals. Two implants were installed on each tibia in the dogs. Implants of the control group were installed with no additional graft. Those of the experimental group 1 were installed with autogenous bone graft from the ilium autogenous bone. Platelet rich plasma (PRP) alone was used in experimental group 2 and the mixture of PRP and autogenous bone was used in experimental group 3. The animals were sacrificed at 8 weeks after implantation. The parts of tibia containing implant were harvested and radiographs were taken for radiographic examination. The specimens were prepared for histological examination and histomorphometric analysis of implant-bone contact ratios. Results: 1. All implants showed sufficient osseointegration in the cortical bone radiographically and histologically, but osseointergration in the marrow space was not satisfactory. 2. Histomorphometrically, the implant-bone contact ratios in the bone marrow was sequentially high in the experimental group 3 (autogenous bone + PRP group), group 1 (autogenous bone group), group 2 (PRP group), and control group (non-additive). 3. It was verified that there was statistical significance between two experimental groups (group 1 and 3) and the other groups (group 2 and control group). (P<0.005) 4. However, there was no statistical significance between group 3 and group 1, also group 2 and control group respectively. Conclusion: These results suggest that platelet rich plasma is effective to osseointegration in the implant installation but there is no statistical significance.

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References

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