한국환경과학회지 (Journal of Environmental Science International)

  • 제19권2호
  • /
  • Pages.209-215
  • /
  • 2010
  • /
  • 1225-4517(pISSN)
  • /
  • 2287-3503(eISSN)
한국환경과학회 (The Korean Environmental Sciences Society)
권호 표지
DOI QR코드

DOI QR Code

엑스과립과 환으로 만들어진 한방생약제제의 aflatoxin B1 연구

A Study on the Concentration of Aflatoxin B1 in Granule and Globular Types of Herbal Medicines

  • 배종섭 (대구한의대학교 한방제약공학과) ;
  • 김용웅 (대구한의대학교 한방제약공학과) ;
  • 박문기 (대구한의대학교 한방제약공학과)
  • Bae, Jong-Sup (Department of Herbal Pharmaceutical Engineering, Daegu Haany University) ;
  • Kim, Yong-Ung (Department of Herbal Pharmaceutical Engineering, Daegu Haany University) ;
  • Park, Moon-Ki (Department of Herbal Pharmaceutical Engineering, Daegu Haany University)
  • 투고 : 2009.10.16
  • 심사 : 2010.02.12
  • 발행 : 2010.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study is an endeavor to evaluate the risk assessment of hazardous(aflatoxin $B_1$) in medicines from oriental medical prescription which are circulated much recently. For that, twelve globular and granule types, seven liquid types of herbal medicine were bought to compare and analyze the content of aflatoxin aflatoxin B_1), which are harmful to human body. Woo Hwang Cheong Sim Hwan of Aflatoxin $B_1$ concentration lower than the standard accepted by all the products have been detected, B company(tradition) is the concentration of $1.24\;{\mu}g/kg$, C company $1.04\;{\mu}g/kg$, A company(tradition) and B company did not detect. And the general pill of aflatoxin B1 concentration lower than the standard accepted by all the products have been detected, S-1 is the concentration of $1.8\;{\mu}g/kg$, S-2 of $1.04\;{\mu}g/kg$, S-3 of $0.88\;{\mu}g/kg$, S-4 of $9.32\l\;{\mu}g/kg$, S-6 of $7.8\;{\mu}g/kg$, S-5 did not detect. All the products eundan allowed in the concentration of aflatoxin $B_1$ levels were lower than detection, D company of $0.96\;{\mu}g/kg$, E company concentration was not detected. The liquid product of aflatoxin $B_1$ concentration was found liwer than the standard accepted by all the product, L-3 concentration of $0.8\;{\mu}g/kg$, K-4 was detected in the $1.16\;{\mu}g/kg$, L-1 and L-2 is not detected, L-5 concentration of $15\;{\mu}g/kg$, L-7 is detected as $1.08\;{\mu}g/kg$ and, L-6 was not detected.

키워드

참고문헌

  1. Akiyama, H., Goda, Y., Tanaka, T., Toyoda, M., 2001, Determination of aflatoxin $B_1,\;B_2,\;G_1,\;G_2$ in spices using a multifunctional column clean-up, J. Chromatogr. A., 932, 153-157. https://doi.org/10.1016/S0021-9673(01)01211-0
  2. Babaunmi, E. A., Bassir, O., 1972, Effects of aflatoxin $B_1$ on the swelling and adenosin triphophatase activities of mitochondria isolated from different tissues of the rat, FEBS Lett., 26, 102. https://doi.org/10.1016/0014-5793(72)80551-9
  3. Bae, S. I., Kwak, B. Y., Park, Y. K., Kim, Y. H., Shon, D. H., 2003, Survey of aflatoxin $B_1$ in domestic doenjang and kochujang determined by enzyme linked- immunosorbent assay, J. Food Hyg. Saf., 18, 95-100.
  4. Barnes, J. M., 1970, Aflatoxin as a health hazard, J. Appli. Bacteriol., 33, 285. https://doi.org/10.1111/j.1365-2672.1970.tb02200.x
  5. Blesa, J., Soriano, J. M., Molto, J. C., Manes, J., 2004, Limited survey for the presence of alfatoxins in foods from local markets and supermarkets inValencia, Spain, Food Addit. Contam. 21, 165-171. https://doi.org/10.1080/0265203031000
  6. Buser, M. D., Abbas, H. K., 2002, Effects of extrusion temperature and dwell time on aflatoxin levels in cottonseed, J. Agr. Food Chem., 50, 2556-2559. https://doi.org/10.1021/jf011479x
  7. Das, C., Mishrain, H. N., 2000, In vitro degradation of aflatoxin B1 by horse radish peroxidase, Food Chem., 68, 309-313. https://doi.org/10.1016/S0308-8146(99)00196-X
  8. Doherty, W. P., Campbell, T. C., 1973, Aflatoxin Inhibition of rat-liver mitochondria, Chem. Biol. Interact., 7, 63. https://doi.org/10.1016/0009-2797(73)90016-1
  9. Giray, B., Girgin, G., Engin, A. B., Aydin, S., Sahin, G., 2007, Aflatoxin levels in wheat samples conumed in some regions of Turkey, Food Control, 18, 23-29. https://doi.org/10.1016/j.foodcont.2005.08.002
  10. Iamanaka, B. T., de Menezes, H. C., Vicente, E., Leite, R. S. F., Taniwaki, M. H., 2007, Aflatoxigenic fungi and aflatoxins occurrence in sultanas and dried figs commercialized in Brazil, Food Control, 18, 454-457. https://doi.org/10.1016/j.foodcont.2005.12.002
  11. Jung, D. H., Park, M. K., 2008, The Content of Heavy Metals in Manufactured Herbal Medicines, J. of the Environmental Sciences, 17(1), 129-133. https://doi.org/10.5322/JES.2008.17.1.129
  12. Krishnamarchari, K. A. V. R., Bhat, R. V., Nagajaran, V., Tilak, T. B. G., 1975, Hepatitis due to aflatoxicosis, Lanceti, 1061.
  13. Lee, S. E., Campbell, B. C., Molyneux, R. J., Hasegawa, S., Lee, H. S., 2001, Inhibitory effects of naturally occurring compounds on aflatoxin $B_1$ biotransformation, J. Agr. Food Chem., 49, 5171-5177. https://doi.org/10.1021/jf010454v
  14. Nguyen, T. V., Park, M. K., 2007, Determination of Mineral and Trace Elements in Ganoderma Lucidum Consumed in China, Vietnam and Korea, J.of the Environmental Sciences, 16(1), 21-26. https://doi.org/10.5322/JES.2007.16.1.021
  15. Patterson, D. S. P., 1973, Metabolism as a factor in determining toxic action of aflatoxins in different animal species, Food Cosmet. Toxicol., 11, 287. https://doi.org/10.1016/S0015-6264(73)80496-1
  16. Pokrovsky, A. A., Kravchenco, L. V., Tutelyan, V. A., 1972, Effcet of aflatoxin on rat liver lysosomes, Toxicon, 10, 25. https://doi.org/10.1016/0041-0101(72)90086-4
  17. Rustom, I. Y. S., 1997, Aflatoxin in food and feed: Occurrence, legislation and inactivation by physical methods, Food Chem. 59, 57-67. https://doi.org/10.1016/S0308-8146(96)00096-9
  18. Schmidt, F. R., Esser, K., 1985, Aflatoxins: Medical, economic impact and prospects for control, Process Bio-chemistry, 20, 167.
  19. IARC monographs on the evaluation of carcinogenic risks to humans. Agents reviewed by the IARC monographs, Volumes 197, Accessed Aug. 13, 2007, http://monographs.iarc.fr/ENG/ Classification/ crthallalp.php.