Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Decreased Levels of Plasma Testosterone/LH Ratio in Male Mice Exposed to Sodium Arsenite

  • Chang, Soo-Im (College of Veterinary Medicine, Seoul National University) ;
  • Kim, Soo-Hee (College of Veterinary Medicine, Seoul National University) ;
  • Park, Jung-Duck (College of Medicine, Chung-Ang University) ;
  • Ryu, Doug-Young (College of Veterinary Medicine, Seoul National University)
  • Received : 2010.05.13
  • Accepted : 2010.06.29
  • Published : 2010.07.31
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Abstract

While it's been shown that arsenic impairs male reproductive function, it remains unclear whether the mechanism involves an effect on testosterone (T) production. We examined plasma T and luteinizing hormone (LH) levels in mice given water containing either 20 or 40 mg/L sodium arsenite (SA). The plasma T levels were lower in SA-treated mice than in controls and correlated well with testicular T levels within individuals. However, SA treatment did not significantly affect plasma LH levels. The ratio of plasma T to LH was reduced by the treatment with 40 mg/L SA. These results suggest arsenic-induced defect in testicular testosterone production in mice.

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References

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