Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Congener Specific Profiles and Exposure Pathways of Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk of Chuncheon Area

춘천지역 모유 중 폴리브롬화디페닐메테르(PBDEs)의 이성체별 분포특성과 노출경로

  • We, Sung-Ug (Department of Environmental Engineering, Kyungnam University) ;
  • Baek, In-Cheon (Department of Environmental Engineering, Kyungnam University) ;
  • Park, Sang-Ah (Department of Environmental Engineering, Kyungnam University) ;
  • Kang, Seong-Hoon (Department of Environmental Engineering, Kyungnam University) ;
  • Cho, Yu-Jin (Department of Environmental Engineering, Kyungnam University) ;
  • Cho, Bong-Hui (Department of Environmental Engineering, Kyungnam University) ;
  • Yoon, Cho-Hee (Department of Environmental Engineering, Kyungnam University) ;
  • Kim, Ki-Ho (Center for Instrumental Analysis, Kyungnam University) ;
  • Min, Byung-Yoon (Department of Environmental Engineering, Kyungnam University)
  • Received : 2009.12.02
  • Accepted : 2010.03.04
  • Published : 2010.03.30
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Abstract

This study was carried out to investigate the exposure pathway of PBDEs in human breast milk collected from new mothers residing in Chuncheon, a comparatively clean area in Korea. The congeners of PBDE in 22 human breast milk samples were analyzed using a high resolution gas chromatography with a high resolution mass detector. The residue level of ${\sum}PBDEs$ was higher in primipara subjects than in multipara subjects (p<0.05). The levels in this study were similar to those of people in some Asian and European countries, but were lower than those of people in north America. In the congener profiles, BDE-47 (mean contribution=36.1%) was predominant, followed by BDE-153 (27%), BDE-99 (11.7%), BDE-100 (11.1%), BDE-28 (7.9%) and BDE-183 (3.5%). The sum of BDE-47 and BDE-153 accounted for more than 50% of ${\sum}PBDEs$ in most samples. BDE-47 was highly correlated with ${\sum}PBDEs$ (r=0.94, p<0.001). No strong trend was observed between PBDE levels and a number of key biological factors (women's age, weight, height and body mass index) examined in this study, however, weak correlations were observed in PBDE levels measured against dietary habits, particularly in fish consumption frequency. It seems that Korean people might be exposed to multiple sources including products of PBDEs, and particularly food resources.

본 연구는 비교적 청정한 지역인 춘천시에 거주하는 일반인 모유 중 PBDEs의 노출 경로를 확인하기 위해 처음으로 시도된 연구이다. 본 연구지역의 모유 중 ${\sum}PBDEs$의 수준은 북아메리카지역에 비하여 낮은 수준이었으나 일부 아시아, 유럽국가와 유사하였다. 모유 내 PBDEs의 축적은 산모의 특성과 상관관계가 나타나지 않았으나, 상엽용 PBDEs 제품을 포함하여 여러 복합적 인자에 의하여 노출되고 있었으며, 식품 섭취와 같은 식이노출은 한국인에 있어 중요한 노출 경로의 하나로 판단되었다. 따라서 본 연구 결과는 한국인의 PBDEs 노출 경로 파악에 중요한 정보를 제공하여, 장차 PBDEs 및 관련 브롬계 난연제의 노출에 따른 인체 위해성 평가를 수행함에 있어 중요한 참고자료가 될 것이다. 또한, 한국 내의 PBDEs에 대한 인체노출 경로를 명확하게 하기 위한 연구는 계속적으로 이루어져야 할 것이다.

Keywords

References

  1. Akutsu, K., M. Kitagawa, H. Nakazawa, T. Makino, K. Iwazaki, H. Oda, and S. Hori. 2003. Time-trend (1973-2000) of polybrominated diphenyl ethers in Japanese mother’s milk. Chemosphere 53, 655-654. https://doi.org/10.1016/S0045-6535(03)00517-4
  2. Bi, X., W. Qu, G. Sheng, W. Zhang, B. Mai, D. Chen, L. Yu, and J. Fu. 2006. Polybrominated diphenyl ethers in South China maternal and fetal blood and breast milk. Environ. Pollut. 144, 1024-1030. https://doi.org/10.1016/j.envpol.2005.12.056
  3. Bocio, A., J. M. Llobet, J. L. Domingo, J. Corbella, A. Teixido, and C. Casas. 2003. Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet. Journal of Agricultural and Food Chemistry 51, 3191-3195. https://doi.org/10.1021/jf0340916
  4. BSEF, 2007. Bromine Science and Environmental Forum, available at (April 3, 2008).
  5. Chao, H. R., S. L. Wang, C. C. Lee, H. Y. Yu, Y. K. Lu, and O. Papke. 2004. Level of polychlorinated dibenzo-p- dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs) in human milk and the input to infant body burden. Food Chem. Toxicol. 42, 1299-1308. https://doi.org/10.1016/j.fct.2004.03.008
  6. Chao, H. R., S. L. Wang, W. J. Lee, Y. F. Wang, and O. Papke. 2007. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ. Int. 33, 239-245. https://doi.org/10.1016/j.envint.2006.09.013
  7. Darnerud, P. O., G. S. Eriksen, T. Johannesson, P. B. Larsen, and M. Vilekula. 2001. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ. Health Perspect. 109, 49-68. https://doi.org/10.2307/3434846
  8. de Wit, C. A. 2002. An overview of brominated flame retardants in the environment. Chemosphere 46, 583-624. https://doi.org/10.1016/S0045-6535(01)00225-9
  9. Eslami, B., A. Koizumi, S. Ohta, K. Inoue, O. Aozasa, and et al. 2006. Large-scale evaluation of the current level of polybrominated diphenyl ethers (PBDEs) in breast milk from 13 regions of Japan. Chemosphere 63, 554-561. https://doi.org/10.1016/j.chemosphere.2005.09.067
  10. European Union (EU), 1999. Risk Assessment Report : Octabromo diphenylether, derivate, Final Draft.
  11. Gill, U., I. Chu, J. J. Ryan, and M. Feedley. 2004. Polybrominated diphenyl ethers: Human tissue levels and toxicology. Reviews of Environmental Contamination and Toxicology 183, 55-97. https://doi.org/10.1007/978-1-4419-9100-3_3
  12. Hale, R. C., M. J. L. Guardia, E. Harvey, and T. M. Mainor. 2002. Potential role of fire retardant-treated polyurethane foam as a source of brominated diphenyl ethers to the US environment. Chemosphere 46, 729-735. https://doi.org/10.1016/S0045-6535(01)00237-5
  13. Hites, R. A. 2004. Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Environ. Sci. Technol. 38, 945-956. https://doi.org/10.1021/es035082g
  14. Huwe, J. K. and D. J. Smith. 2007. Accumulation, whole-body depletion, and debromination of decabromodiphenyl ether in male Sprague-Dawley rats following dietary exposure. Environ. Sci. Technol. 41, 2371-2377. https://doi.org/10.1021/es061954d
  15. Ingelido, A. M., T. Ballard, E. Dellatte, A. D. Domenico, F. Ferri, A. R. Fulgenzi, T. Herrmann, N. Iacovella, R. Miniero, O. Papke, M. G. Porpora, and E. D. Felip. 2007. Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in milk from Italian women living in Rome and Venice. Chemosphere 67, 301-306. https://doi.org/10.1016/j.chemosphere.2006.05.111
  16. Jakobsson, K., K. Thuresson, P. Hoglund, A. Sjodin, L. Hagmar, and A. Bergman. 2003. A summary of exposures to polybrominated diphenyl ethers (PBDEs) in Swedish workers and determination of half-lives of PBDEs. Organohal. Comp. 61, 17-20.
  17. Jaraczewska, K., J. Lulek, A. Covaci, S. Voorspoels, A. Kaluba-Skotarczak, K. Drews, and P. Schepens. 2006. Distribution of polychlorinated biphenyls, organochlorine pesticides and polybrominated diphenyl ethers in human umbilical cord serum, maternal serum and milk from Wielkopolska region, Poland. Science of the Total Environment 372, 20-31. https://doi.org/10.1016/j.scitotenv.2006.03.030
  18. Kalantzi, O. I., F. L. Martin, G. O. Thomas, R. E. Alcock, H. R. Tang, S. C. Drury, P. L. Carmichael, J. K. Nicholson, and K. C. Jones. 2004. Different levels of polybrominated diphenyl ethers (PBDEs) and chlorinated compounds in breast milk from two U.K. regions. Environ. Health Perspect. 112, 1085-1091. https://doi.org/10.1289/ehp.6991
  19. KHIDI. 2006. Report on 2005 national health and nutrition survey-Nutrition survey. Korea Health Industry Development Institute (in Korean).
  20. Korea Environment Institute (KEI), 2005. International regulations and counterplans of brominated flame retardants. Korea Environment Institute, Seoul, Korea.
  21. La Guardia, M. J., R. C. Hale, and E. Harvey. 2006. Detailed polybrominated diphenyl ether (PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures. Environ. Sci. Technol. 40, 6247-6254. https://doi.org/10.1021/es060630m
  22. Li, J., H. Yu, Y. Zhao, G. Zhang, and Y. Wu. 2008. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from Beijing, China. Chemosphere 73, 182-186. https://doi.org/10.1016/j.chemosphere.2008.05.019
  23. Lind, Y., P. O. Darnerud, S. Atuma, M. Aune, W. Becker, R. Bjerselius, S. Cnattingius, and A. Glynn. 2003. Polybrominated diphenyl ethers in breast milk from Uppsala County, Sweden. Environmental Research 93, 186-194 https://doi.org/10.1016/S0013-9351(03)00049-5
  24. McDonald, T. A. 2002. A perspective on the potential health risks of PBDEs. Chemosphere 46, 745-755. https://doi.org/10.1016/S0045-6535(01)00239-9
  25. Meerts, I. A. T. M., J. J. van Zanden, E. A. C. Luijks, I. van Leeuwen-Bol, G. Marsh, E. Jakobsson, A. A. Bergman, and A. Brouwer. 2000. Potent competitive interaction of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol. Sci. 56, 95-104. https://doi.org/10.1093/toxsci/56.1.95
  26. Meironyte, D., A. Bergman, and K. Noren. 2001. Polybrominated diphenyl ethers in Swedish human liver and adipose tissue. Arch. Environ. Contam. Toxicol. 40, 564-570. https://doi.org/10.1007/s002440010211
  27. Noren, K. and D. Meironyte. 2000. Certain organochlorine and organobromine contaminants in swedish human milk in perspective of past 20-30 years. Chemosphere 40, 1111-1123. https://doi.org/10.1016/S0045-6535(99)00360-4
  28. Ohta, S., D. Ishizuka, H. Nishimura, T. Nakao, O. Aozosa, and Y. Shimidzu. 2002. Comparison of polybrominated diphenyl ethers in fish, vegetables, and meat and levels in human milk of nursing women in Japan. Chemosphere 46, 689-696. https://doi.org/10.1016/S0045-6535(01)00233-8
  29. Petreas, M., J. She, F. R. Brown, J. Winkler, G. Windham, E. Rogers, G. Zhao, R. Bhatia, and M. J. Charles. 2003. High body burdens of 2,2,4,4-tetrabromodiphenyl ether (BDE-47) in California women. Environ. Health Perspect 111, 1175-1179. https://doi.org/10.1289/ehp.6220
  30. Ramos, J. J., B. Gomara, M. A. Fernandez, and M. J. Gonzalez. 2007. A simple and fast method for the simultaneous determination of polychlorinated biphenyls and polybrominated diphenyl ethers in small volumes of human serum. Journal of Chromatography A 1152, 124-129. https://doi.org/10.1016/j.chroma.2006.12.050
  31. Ramu, K., N. Kajiwara, T. Isobe, S. Takahashi, E. Y. Kim, B. Y. Min, S. U. We, and S. Tanabe. 2007. Spatial distribution and accumulation of brominated flame retardants, polychlorinated biphenyls and organochlorine pesticides in blue mussels (Mytilus edulis) from coastal waters of Korea. Environ. Pollut. 148, 562-569. https://doi.org/10.1016/j.envpol.2006.11.034
  32. Schecter, A., M. Pauk, O. Papke, J. J. Ryan, L. Birnbaum, and R. Rosen. 2003. Polybrominated diphenyl ethers (PBDEs) in US mothers milk. Environ. Health Perspect. 111, 1723-729. https://doi.org/10.1289/ehp.6466
  33. She, J., A. Holden, M. Sharp, M. Tanner, C. Williams-Derry, and K. Hooper. 2007. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from the Pacific Northwest. Chemosphere 67, 307-317. https://doi.org/10.1016/j.chemosphere.2006.05.154
  34. Sjodin, A., L. Hagmar, E. Klasson-Wehler, J. Bjork, and A. Bergman. 2000. Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. Environ. Health Perspect. 108, 1035-1041. https://doi.org/10.1289/ehp.001081035
  35. Sjodin, A., R. S. Jones, J. F. Focant, C. Lapeza, R. Y. Wang, E. E. McGahee III, Y. Zhang, W. E. Y., Turner, B. Slazyk, L. L. Needham, and D. G. Patterson Jr. 2004. Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States. Environ. Health Perspect. 112, 654-658. https://doi.org/10.1289/ehp.6826
  36. Stapleton, H. M., B. Brazil, R. D. Holbrook, C. L. Mitchelmore, R. Benedict, A. Konstantinov, and D. Potter. 2006. In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp. Environ. Sci. Technol. 40, 4653-4658. https://doi.org/10.1021/es060573x
  37. Sudaryanto, A., N. Kajiwara, O. Tsydenova, H. Iwata, T. A. Adibroto, H. Yu, K. H. Chung, A. Subramanian, M. Prudente, T. S. Tana, and S. Tanabe. 2005. Global contamination of PBDEs in human milk from Asia. Organohal. Comp. 67, 1315-1318.
  38. Sudaryanto, A., N. Kajiwara, S. Takahashi, and S. Tanabe. 2008. Geographical distribution and accumulation features of PBDEs in human breast milk from Indonesia. Environ. Pollut. 151, 130-138. https://doi.org/10.1016/j.envpol.2007.02.016
  39. Thomsen, C., E. Lundanes, and G. Becher. 2002. Brominated flame retardants in archived serum samples from Norway: a study on temporal trends and the role of age. Environ. Sci. Technol. 36, 1414-1418. https://doi.org/10.1021/es0102282
  40. Toms, L. M. L., F. A. Harden, R. K. Symons, D. Burniston, P. Furst, and J. F. Muller. 2007. Polybrominated diphenyl ethers (PBDEs) in human milk from Australia. Chemosphere 68, 797-803. https://doi.org/10.1016/j.chemosphere.2007.02.059
  41. USEPA. 2004. Dioxin reassessment. Draft 2004. Washington, D.C.: U.S. Environmental Protection Agency.
  42. Van den Steen, E., A. Covaci, V. L. B. Jaspers, T. Dauwe, S. Voorspoels, M. Eens, and R. Pinxten. 2007. Accumulation, tissue-specific distribution and debromination of decabromodiphenyl ether (BDE 209) in European starlings (Sturnus vulgaris). Environ. Pollut. 148, 648-653. https://doi.org/10.1016/j.envpol.2006.11.017
  43. Vieth, B., T. Herrmann, H. Mielke, B. Ostermann, O. Paepke, and T. Rudiger. 2004. PBDE levels in human milk: the situation in Germany and potential influencing factors - a controlled study. Organohal. Comp. 66, 2643-2648.
  44. Voorspoels, S., A. Covaci, H. Neels, and P. Schepens. 2007. Dietary PBDE intake: A market-basket study in Belgium. Environ. Int. 33, 93-97. https://doi.org/10.1016/j.envint.2006.08.003
  45. Wang, X. M., X. Ding, B. X. Mai, Z. Q. Xie, C. H. Xiang, L. G. Sun, G. Y. Sheng, J. M. Fu, and E. Y. Zeng. 2005. Polybrominated diphenyl ethers in airborne particulates collected during a research expedition from the Bohai Sea to the Arctic. Environ. Sci. Technol. 39, 7803-7809. https://doi.org/10.1021/es051088p
  46. We, S. U., K. H. Kim, J. H. Baek, S. Y. Han, and B. Y. Min. 2008. Polybrominated Diphenyl Ethers Contamination of Korea Food. Proceedings of Environmental Health in Asia-Pacific Region May 29-30. Jeju, Korea.
  47. WHO. 1994. Environmental Health Criteria 162. Brominated diphenyl ethers. International Programme on Chemical Safety. World Health Organization, Geneva, Switzerland.
  48. Wu, N., T. Herrmann, O. Paepke, J. Tickner, R. Hale, E. Harvey, M. LaGuardia, M. D. McClean, and T. F. Webster. 2007. Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations. Environ. Sci. Technol. 41, 1584-1589. https://doi.org/10.1021/es0620282
  49. Zenneg, M., M. Kohler, A. C. Gerecke, and P. Schmid. 2003. Polybrominated diphenyl ethers in whitefish from Swiss lakes and farmed rainbow trout. Chemosphere 51, 545-553. https://doi.org/10.1016/S0045-6535(03)00047-X
  50. Zhou, T., D. G. Ross, M. J. DeVito, and K. M. Crofton. 2001. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol. Sci. 61, 76-82. https://doi.org/10.1093/toxsci/61.1.76
  51. Zhu, L., B. Ma, J. Li, Y. Wu, and J. Gong. 2009. Distribution of polybrominated diphenyl ethers in breast milk from North China: Implication of exposure pathways. Chemosphere 74, 1429-1434. https://doi.org/10.1016/j.chemosphere.2008.12.030

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