DOI QR코드

DOI QR Code

Disseminated Scedosporium apiospermum Infection Induced from Aspiration Pneumonia after Near-Drowning

익수 후 발생한 흡인성 폐렴에서 유발된 파종성 Scedosporium apiospermum 감염 1예

  • Won, Ho-Youn (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Kim, Hyung-Rae (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Kim, Dong-Hwan (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Oh, Jae-Won (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Ki, Jung-Hye (Department of Pathology, National Health Insurance Corporation Ilsan Hospital) ;
  • Han, Chang-Hun (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Lee, Sun-Min (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital) ;
  • Kim, Cheong-Ju (Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital)
  • 원호연 (국민건강보험공단 일산병원 내과) ;
  • 김형래 (국민건강보험공단 일산병원 내과) ;
  • 김동환 (국민건강보험공단 일산병원 내과) ;
  • 오재원 (국민건강보험공단 일산병원 내과) ;
  • 기정혜 (국민건강보험공단 일산병원 병리과) ;
  • 한창훈 (국민건강보험공단 일산병원 내과) ;
  • 이선민 (국민건강보험공단 일산병원 내과) ;
  • 김정주 (국민건강보험공단 일산병원 내과)
  • Received : 2010.06.15
  • Accepted : 2010.09.15
  • Published : 2010.10.30

Abstract

Scedosporium apiospermum, the anamorph of Pseudallescheria boydii, is a ubiquitous saprophytic fungus. S. apiospermum can cause life-threatening infections usually in immunocompromised patients or after near-drowning incidents. Here, we report the first case of disseminated infection caused by S. apiospermum after near-drowning in Korea. A 44-year-old healthy man developed aspiration pneumonia, followed by multiple brain abscesses, and endopthalmitis, after a near-drowning incident in a septic tank. S. apiospermum infection was diagnosed on the 33rd day after the incident had occurred. The patient died from the progressive renal failure 255 days after incident, although he had been treated with voriconazole.

Keywords

References

  1. Cortez KJ, Roilides E, Quiroz-Telles F, Meletiadis J, Antachopoulos C, Knudsen T, et al. Infections caused by Scedosporium spp. Clin Microbiol Rev 2008;21: 157-97. https://doi.org/10.1128/CMR.00039-07
  2. Kaltseis J, Rainer J, De Hoog GS. Ecology of Pseudallescheria and Scedosporium species in human-dominated and natural environments and their distribution in clinical samples. Med Mycol 2009;47:398-405. https://doi.org/10.1080/13693780802585317
  3. Buzina W, Feierl G, Haas D, Reinthaler FF, Holl A, Kleinert R, et al. Lethal brain abscess due to the fungus Scedosporium apiospermum (teleomorph Pseudallescheria boydii) after a near-drowning incident: case report and review of the literature. Med Mycol 2006; 44:473-7. https://doi.org/10.1080/13693780600654588
  4. Katragkou A, Dotis J, Kotsiou M, Tamiolaki M, Roilides E. Scedosporium apiospermum infection after neardrowning. Mycoses 2007;50:412-21. https://doi.org/10.1111/j.1439-0507.2007.01388.x
  5. Kowacs PA, Soares Silvado CE, Monteiro de Almeida S, Ramos M, Abrao K, Madaloso LE, et al. Infection of the CNS by Scedosporium apiospermum after near drowning. Report of a fatal case and analysis of its confounding factors. J Clin Pathol 2004;57:205-7. https://doi.org/10.1136/jcp.2003.8680
  6. van der Vliet JA, Tidow G, Kootstra G, van Saene HF, Krom RA, Sloof MJ, et al. Transplantation of contaminated organs. Br J Surg 1980;67:596-8. https://doi.org/10.1002/bjs.1800670822
  7. Haukohl RS, Sadoff HB. Mycetoma: report of a case due to Monosporium apiospermum in a native of Minnesota. Wis Med J 1954;53:477-9.
  8. Chung JW, Park SJ, Sung H, Kim MN, Kim BS, Lee SG. A case of disseminated infection due to Scedosporium apiospermum in a liver-transplantation recipient. Korean J Lab Med 2005;25:421-4.
  9. Nucci M. Emerging moulds: Fusarium, Scedosporium and Zygomycetes in transplant recipients. Curr Opin Infect Dis 2003;16:607-12. https://doi.org/10.1097/00001432-200312000-00015
  10. Troke P, Aguirrebengoa K, Arteaga C, Ellis D, Heath CH, Lutsar I, et al. Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients. Antimicrob Agents Chemother 2008;52:1743-50. https://doi.org/10.1128/AAC.01388-07
  11. Hariprasad SM, Mieler WF, Holz ER, Gao H, Kim JE, Chi J, et al. Determination of vitreous, aqueous, and plasma concentration of orally administered voriconazole in humans. Arch Ophthalmol 2004;122:42-7. https://doi.org/10.1001/archopht.122.1.42
  12. Jain A, Egbert P, McCulley TJ, Blumenkranz MS, Moshfeghi DM. Endogenous Scedosporium apiospermum endophthalmitis. Arch Ophthalmol 2007;125: 1286-9. https://doi.org/10.1001/archopht.125.9.1286
  13. Yoo D, Lee WH, Kwon-Chung KJ. Brain abscesses due to Pseudallescheria boydii associated with primary non-Hodgkin's lymphoma of the central nervous system: a case report and literature review. Rev Infect Dis 1985;7:272-7. https://doi.org/10.1093/clinids/7.2.272