Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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The Clinical and Pathologic Features according to Expression of Acyl Protein Thioesterase-1 (APT1) in Stage I Non-small Cell Lung Cancer

제1기 비소세포폐암에서 APT1 발현의 임상적 의미

  • Shin, Jung-Ar (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Chang-Ryul (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Byun, Min-Kwang (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Yoon-Soo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Se-Kyu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Joon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Ahn, Chul-Min (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyung-Jung (Department of Internal Medicine, Yonsei University College of Medicine)
  • 신정아 (연세대학교 의과대학 내과학교실) ;
  • 이창률 (한림대학교 의과대학 춘천성심병원 내과학교실) ;
  • 변민광 (연세대학교 의과대학 내과학교실) ;
  • 장윤수 (연세대학교 의과대학 내과학교실) ;
  • 김세규 (연세대학교 의과대학 내과학교실) ;
  • 장준 (연세대학교 의과대학 내과학교실) ;
  • 안철민 (연세대학교 의과대학 내과학교실) ;
  • 김형중 (연세대학교 의과대학 내과학교실)
  • Received : 2010.03.09
  • Accepted : 2010.03.31
  • Published : 2010.04.30
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Abstract

Background: Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. Methods: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Results: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. Conclusion: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.

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References

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