Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Acute Pulmonary Embolism: Clinical Characteristics and Outcomes in a University Teaching Hospital

한 대학병원에서 급성 폐색전증으로 진단된 환자들의 임상적 특성 및 예후

  • Chae, Jin-Nyeong (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Choi, Won-Il (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Park, Jie-Hae (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Rho, Byung-Hak (Department of Diagnostic Radiology, Keimyung University School of Medicine) ;
  • Kim, Jae-Bum (Department of Thoracic Surgery, Keimyung University School of Medicine)
  • 채진녕 (계명대학교 의과대학 내과학교실) ;
  • 최원일 (계명대학교 의과대학 내과학교실) ;
  • 박지혜 (계명대학교 의과대학 내과학교실) ;
  • 노병학 (계명대학교 의과대학 영상의학교실) ;
  • 김재범 (계명대학교 의과대학 흉부외과학교실)
  • Received : 2009.11.24
  • Accepted : 2009.12.29
  • Published : 2010.03.30
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Abstract

Background: Pulmonary embolism (PE) is a common clinical problem in the West that is associated with substantial morbidity and mortality. The diagnostic modality has been changed since 2001. This study retrospectively reviewed the PE mortality with the aim of identifying the risk factors associated with mortality since the multidetector computed tomography (MDCT) was introduced. Methods: We analyzed 105 patients with acute PE proven by multidetector CT or ventilation perfusion scan. The primary outcome measure was the all-cause mortality at 3 months. The prognostic effect of the baseline factors on survival was assessed by multivariate analysis. Results: The main risk factors were prolonged immobilization, stroke, cancer and obesity. Forty nine percent of patients had 3 or more risk factors. The overall mortality at 3 months was 18.1%. Multivariate analysis revealed low diastolic blood pressure and the existence of cancer to be independent factors significantly associated with mortality. Forty two PE patients were examined for the coagulation inhibitors. Four of these patients had a protein C deficiency (9.5%), and 11 had a protein S deficiency (26%). Conclusion: PE is an important clinical problem with a high mortality rate. Close monitoring may be necessary in patients with the risk factors.

Keywords

References

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