The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Anti-platelet Aggregation Effect of Cheongpyesagan-tang In Vitro

청폐사간탕(淸肺瀉肝湯)의 혈소판 응집억제 작용에 대한 in vitro 연구

  • Park, Young-Ju (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Seul-Ji (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Yang, Ga-Eun (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Mi-Jung (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Ji-Sook (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Kang, Deok-Hui (East-West Medicine, The Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Kim, Young-Chan (East-West Medicine, The Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Lee, Woo-Kyung (East-West Medicine, The Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Ryu, Jae-Hwan (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University)
  • 박영주 (경희대학교 한의과대학 내과학교실) ;
  • 김슬지 (경희대학교 한의과대학 내과학교실) ;
  • 양가은 (경희대학교 한의과대학 내과학교실) ;
  • 이미정 (경희대학교 한의과대학 내과학교실) ;
  • 이지숙 (경희대학교 한의과대학 내과학교실) ;
  • 강덕희 (경희대학교 동서의학대학원 동서의학과) ;
  • 김영찬 (경희대학교 동서의학대학원 동서의학과) ;
  • 이우경 (경희대학교 동서의학대학원 동서의학과) ;
  • 류재환 (경희대학교 한의과대학 내과학교실)
  • Published : 2010.12.30
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Abstract

Objective : The study was designed to test the anti-platelet effect of the extract Cheongpyesagan-tang and compare it with aspirin in vitro. Methods : The extract from Cheongpyesagan-tang was made by the pharmacy department of Kyung Hee Oriental Medical Hospital. The extract was investigated for inhibition against the collagen induced aggregation of human platelet suspensions on aggregometry. Aspirin and aspirin-Cheongpyesagan-tang were investigated together. Results : 1. In collagen induced human platelet aggregation test, the extract from Cheongpyesagan-tang significantly inhibited in concentration 30mg/ml (p<0.05), 40mg/ml, 50mg/ml (p<0.001) and the effect depended on concentration over 20mg/ml. 2. Aspirin and aspirin-Cheongpyesagan-tang inhibited collagen induced human platelet aggregation significantly (p<0.001). Aspirin-extract of Cheongpyesagan-tang inhibition rate was higher than aspirin only (p<0.05). Conclusions : The extract of Cheongpyesagan-tang has anti-platelet aggregation and synergic effect with aspirin on human platelet in vitro.

Keywords

References

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