The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Nephroprotective Effects of Manjeonmoktong-san on Cisplatin-induced Rat Acute Renal Failure

만전목통산(萬全木通散)이 Cisplatin으로 유발(誘發)된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향(影響)

  • Kim, Do-Nyeon (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Yoon, Gyeong-Min (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Shin, Hyeon-Chul (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Kang, Seok-Bong (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University)
  • 김도년 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 윤경민 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 신현철 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 강석봉 (대구한의대학교 부속한방병원 신계내과학교실)
  • Published : 2010.09.30
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Abstract

Purpose : The object of this study was to observe the nephroprotective effects of Manjeonmoktong-san(MJMTS), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure. Methods : At first, three different dosages of MJMTS extract were orally administered once a day for 28 days. On the 23rd day after MJMTS extract treatment, cisplatin was treated. Then, 5 days after cisplatin treatment, all the rats (6 groups of 8 rats each) were checked in the present study. The changes to the body weight, kidney weight, serum BUN and creatinine levels were observed with changes on the kidney MDA and GSH contents. The results were compared with captopril 100mg/kg in which the effects on cisplatin-induced acute renal failures were already confirmed. Results : It showed dramatical decrease on the body weight, increase of serum BUN and creatinine levels were detected in cisplatin control as compared with intact control. In addition marked increase of kidney MDA contests and decrease of kidney GSH contents were also detected in cisplatin control as compared with intact control. it means that cisplatin induced ARF are induced by oxiidative stress and related lipid peroxidation in the present study. However, these ARFs and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of all three different dosages of MJMTS extracts. Conclusion : This study suggests that MJMTS extracts have favorable effects on the cisplatin-induced rat ARF.

Keywords

References

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