Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Anti-inflammatory Effect of Benincasae Semen Herbal-acupuncture at KI10 on nephritis in rats

음곡(陰谷)에 시술한 동과인 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

  • Lee, Jeong-Hwan (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daejeon University) ;
  • Kim, Jeong-Ho (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daejeon University) ;
  • Kim, Young-Il (Dept. of Acupuncture & Moxibustion College of Oriental Medicine, Daejeon University)
  • 이정환 (대전대학교 한의과대학 침구학교실) ;
  • 김정호 (대전대학교 한의과대학 침구학교실) ;
  • 김영일 (대전대학교 한의과대학 침구학교실)
  • Received : 2010.03.19
  • Accepted : 2010.05.24
  • Published : 2010.06.30
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Abstract

Objective : This study aimed to evaluate the effects of Benincasae Semen Herbal-acupuncture (BS-HA) at KI10 (Umgok) on nephritis induced by LPS in rat. Methods : Rats with nephritis induced by LPS, were treated with Benincasae Semen Herbal-acupuncture(BS-HA) injection at KI10. Two control groups, N.P. group and saline group, were treated with 26 gauge needle at KI10, 3 times a week. In Saline group normal saline was injected at KI10. To evaluate the effects of Benincasae. Semen Herbal-acupuncture at KI10 on nephritis in rats, WBC, Neutrophils in blood, BUN, Creatinine TNF-$\alpha$, CINC-1 in serum, urinal volume and creatinine and Total protein in urine, reanl TNF-$\alpha$, renal MPO were measured and reanl tissue was also analyzed. Results: BS-HA injected at KI10 significantly inhibited WBC and neutrophil in blood. creatinine in serum, and MPO in kidney of LPS-stimulated rats. BS-HA injected at KI10 reduced concentration of neutrophil in renal tissue of LPS-stimulated rats. Conclusion : BS-HA at KI10 has a therapeutic effect for nephritis in LPS-stimulated rat There fore, it is suggested that BS-HA at KI10 may be an useful therapeutics in clinical field after further researches.

Keywords

References

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