YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Pattern of Drugs & Poisons in Autopsy Cases in Korea for Recent Three Years (2007~2009) - Selection of Target Drugs for Systematic Toxicological Analysis -

최근 3년간 국내 변사체 중 약독물 검출 유형(2007~2009) - 약독물 검출 시스템 확립을 위한 목표 약물의 선별 -

  • Kim, Eun-Mi (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • Kim, Ji-Hyun (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • Hong, Hyo-Jeong (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • Jeong, Su-Jin (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • In, Sang-Hwan (Narcotic Analysis Div., National Institute of Scientific Investigation) ;
  • Rhee, Jong-Sook (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • Jung, Jin-Mi (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • Lee, Han-Sun (Drug & Toxicology Div., National Institute of Scientific Investigation) ;
  • Lee, Sang-Ki (Drug & Toxicology Div., National Institute of Scientific Investigation)
  • 김은미 (국립과학수사연구소 약독물과) ;
  • 김지현 (국립과학수사연구소 약독물과) ;
  • 홍효정 (국립과학수사연구소 약독물과) ;
  • 정수진 (국립과학수사연구소 약독물과) ;
  • 인상환 (국립과학수사연구소 마약분석과) ;
  • 이종숙 (국립과학수사연구소 약독물과) ;
  • 정진미 (국립과학수사연구소 약독물과) ;
  • 이한선 (국립과학수사연구소 약독물과) ;
  • 이상기 (국립과학수사연구소 약독물과)
  • Received : 2010.04.27
  • Accepted : 2010.08.18
  • Published : 2010.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

The majority of forensic autopsies in Korea are performed by the National Institute of Scientific Investigation (NISI), and the NISI has carried out about 4,000 cases annually. Total 4,578 autopsies were performed by NISI in 2009, among them 2,918 cases (64%) were carried out at main office of NISI in Seoul, which is in charge of Seoul, Incheon and Gyeonggi province. In this study we investigated pattern of drugs & poisons in autopsy cases for recent three years in Korea. Postmortem specimens (bloods, gastric contents, etc) from autopsy cases by main office of NISI during 2007~2009 were screened for drugs & poisons. Using laboratory information management system of NISI (iLIMS), the kinds of drugs & poisons and the frequency were investigated. As the results, 1,705 cases were negative to drugs & poisons, it occupied 58% of total 2,918 autopsy cases in 2009. During three years (2007~2009), the kinds of drugs & poisons detected in specimens were 206, 185 and 203, respectively, and top three drugs were atropine (anticholinergic), chlorpheniramine (antihistamine) and lidocaine (local anaesthetic/anti-arrythmic). These drugs were supposed to be used not so much for suicidal or homicidal purpose as for therapeutic purpose in hospital. Meanwhile cyanide showed the highest frequency of poisons during 2007~2009, and the frequency was 32 cases in 2009. In case of pesticides, poisoning by paraquat (herbicide, 17 cases) showed the highest frequency, and methomyl (insecticide, 9 cases) and glyphosate (herbicide, 7 cases) were followed. Finally we selected 62 drugs as target drugs for systematic toxicological analysis (STA) for Korea. Poisons such as pesticides, natural toxins, volatile compounds should be included for STA in further study.

Keywords

References

  1. 국립과학수사연구소 통계자료.
  2. 일본약학회편, 약독물시험법과주해2006-분석, 독성, 대처법-. 동경화학동인 (2006).
  3. 유영찬, 법과학(4개정)-법독성학편-. 신일상사 (2007).
  4. 인상환, 김지현, 홍효정, 이정아, 정진일, 민승식, 하정민, 최화경, 정희선, LC/MS 및 direct MS에 의한 약물 분석 및 Library 구축(II), 27종의 수면진정제류. 국립과학수사연구소연보 40, 334(2008).
  5. 인상환, 김지현, 홍효정, 이정아, 정진일, 민승식, 하정민, 이종숙, 정진미, 이한선, 이재신, 박미정, 박유진, 박찬호, 김선춘, 양희진, 설일웅, 이상기, 박유신, 정희선, LC/MS/MS에 의한 약독물 분석 및 Library 구축(III). 국립과학수사연구소연보 41, 287 (2009).
  6. 최화경, 혈중 수면제의 농도와 사망 원인과 방법에 대한 고찰- Doxylamine에 대하여-, 국립과학수사연구소연보 40, 141 (2008).
  7. Kudo, K., Ishida, T., Hikiji, W., Usumoto, Y., Umehara, T., Nagamatsu, K., Tsuji, A. and Ikeda, N. : Pattern of poisoning in Japan: selection of drugs and poisons for systematic toxicological analysis. Forensic Toxicol. 28, 25 (2010). https://doi.org/10.1007/s11419-009-0088-8
  8. Nishioka, H., Nishikawa, M. and Tsuchihashi, H. : Development of drug identification system for benzodiazepines and their metabolites using GC-MS. Japanese Journal of Forensic Science and Technology 11, 53 (2006). https://doi.org/10.3408/jafst.11.53
  9. 최혜영, 이주선, 최상길, 김은미, 김재균, 김영운, 임미애, 정희선, 음주운전자 275명 혈액 중 마약류 및 남용약물의 분석. 약학회지 52, 137 (2008).
  10. 최혜영, 최상길, 이주선, 김은미, 김선춘, 최화경, 정희선, 약물자동검색시스템을 이용한 범죄사건 관련 소변 중 벤조디아제핀계약물 검출 사례. 한국법과학회지 9, 52 (2008).
  11. Ishida, T., Kudo, K. Naka, S., Toubou, K., Noguchi, T. and Ikeda, N. : Rapid diagnosis of drug intoxication using novel $NAGINATA^{TM}$ gas chromatography/mass spectrometry software. Rapid Communications in Mass Spectrometry 21, 3129 (2007). https://doi.org/10.1002/rcm.3194
  12. Maurer, H. : Forensic screening with GC-MS. Handbook of Analytical Separations 6, 425 (2008).