Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Preliminary Study on Magnetic Resonance Temperature Measurement using Brain-Metabolite Phantom

뇌 대사물질 팬텀을 이용한 뇌의 자기공명 온도측정법에 관한 기초 연구

  • Received : 2010.09.08
  • Accepted : 2010.09.30
  • Published : 2010.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

In this study, we measured the chemical shift change of metabolite peaks in the brain-metabolite phantom according to the temperature variation using nuclear magnetic resonance(NMR). The temperature range in NMR system was controled from 25 to 80 (5 step) by internal temperature controller. Temperature coefficients of each metabolite peaks were also calculated from the measured chemical shift depending on the temperature. The chemical shift changes depending on temperature were validated by linear regression method for each metabolite peaks. The temperature coefficients of $_{tot}Cr$, Cho, Cr, NAA, and Lac were 0.0086, 0.0088, 0.0091, 0.0089, and 0.0088ppm/$^{\circ}C$, respectively. This study shows that chemical shift change of brain metabolite and temperature variation have linear relationship each other. This also makes authors believe that brain temperature measurement is possible using MR spectroscopic imaging technique.

Keywords

Acknowledgement

Supported by : 학술진흥재단

References

  1. Carter DL, MacFall JR, Clegg ST, Wan X, Prescott DM, Charles HC, Samulski TV. Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma. Int J Radiat Oncol Biol Phys 1998;40: 815-822. https://doi.org/10.1016/S0360-3016(97)00855-9
  2. Denis de Senneville B, Quesson B, Moonen CT. Magnetic resonance temperature imaging. Int J Hyperthermia 2005;21: 515-531. https://doi.org/10.1080/02656730500133785
  3. Ishihara Y, Calderon A, Watanabe H, Mori K, Okamoto K, Suzuki Y, Sato K, Kuroda K, Nakagawa N, Tsutsumi S. A precise and fast temperature mapping method using water proton chemical shift. In: Proceedings of the 11th Annual Meeting of SMRM, Berlin, 1992. p 4803.
  4. N. Mcdannold, "Quantitative MRI-based temperature mapping based on the proton resonant frequency shift: Review of validation studies," Int J. Hyperthermia, vol.21(6),pp533-546, 2005. https://doi.org/10.1080/02656730500096073
  5. Young IR, Hajnal JV, Roberts IG, Ling JX, Hill-Cottingham RJ, Oatridge A, Wilson JA. An evaluation of the effects of susceptibility change on water chemical shift method of temperature measurement in human peripheral muscle. Magn Reson Med 1996;36:366-374. https://doi.org/10.1002/mrm.1910360307
  6. Poorter JDE, Wagter CdE, Deene DE, Thomsen C, Stahlberg F, Achten E. Non-invasive MRI thermometry with the proton resonance frequency shift (PRF) method: In vivo results in human muscle. Magn Reson Med 1995;33:74-81. https://doi.org/10.1002/mrm.1910330111
  7. K. Kuroda, R. V. Mulkern, K. Oshio, and L. P. Panych, et al., "Temperature Mapping Using the Water Proton Chemical Shift: Self-Referenced Method With Echo-Planar Spectroscopic Imaging," Magn Reson Med, vol.43,pp.220-225,2000. https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<220::AID-MRM8>3.0.CO;2-9
  8. Kuroda K, Oshio K, Chung AH, Hynynen K, Jolesz FA. Temperature mapping using the water proton chemical shift: a chemical shift selective phase mapping (CSSPM) method. Magn Reson Med 1997;38:845-851. https://doi.org/10.1002/mrm.1910380523
  9. Moriaty JA, Chen JC, Purcell CM, Ang LC, Hinks RS, Peter RD, Henkelman RM, Plewes DB, Bronskill MJ, Kucharczyk W. MRI monitoring of interstitial microwave-induced heating and thermal lesions in rabbit brain in vivo. J Magn Reson Imag 1998;8:128-135. https://doi.org/10.1002/jmri.1880080125
  10. Kahn T, Harth T, Kiwit JCW, Schawarzmaier H-J, Wald C, Mödder U. In vivo MRI thermometry using a phase-sensitive sequence: preliminary experience during MRI-guided laser-induced interstitial thermotherapy of brain tumors. J Magn Reson Imag 1998;8:160-164. https://doi.org/10.1002/jmri.1880080128
  11. Kettenbach J, Silverman SG, Hata N, Kuroda K, Saiviroonporn P, Zientara GP, Morrison PR, Hushek SG, Black PM, Kikinis R, Jolesz FA. Monitoring and visualization technique for MR-guided laser ablation in an open MR system. J Magn Reson Imag 1998;8:933-943. https://doi.org/10.1002/jmri.1880080424
  12. Stollberger R, Huber D, Renhard W, Glanzer H. Influence of the temperature dependent susceptibility on monitoring of interstitial tissue coagulation using the proton resonance frequency method. In: Proceedings of the 5th Annual Meeting of the ISMRM, Vancouver, Canada, 1997. p 1963.
  13. de Zwart JA, Vimeux FC, Delalande C, Moonen CTW. Fast lipid suppressed temperature mapping for the monitoring of focused ultrasound heated tissue. In: Proceedings of the 6th Annual Meeting of ISMRM, Sydney, Australia, 1998. p 350.
  14. Olsen TS, Weber UJ, Kammersgaard LP. Therapeutic hypothermia for acute stroke. Lancet Neurol 2003;2:410 - 6. https://doi.org/10.1016/S1474-4422(03)00436-8
  15. Reith J, Jorgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, et al. Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet 1996;347:422-5. https://doi.org/10.1016/S0140-6736(96)90008-2
  16. Castillo J, Davalos A, Marrugat J, Noya M. Timing for fever-related brain damage in acute ischemic stroke. Stroke 1998;29:2455-60. https://doi.org/10.1161/01.STR.29.12.2455
  17. Ian Marshall, et, al, Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke, Magn Reson Imaging (24) 2009;699-706.
  18. Daiya Ishigaki, Brain Temperature Measured Using Proton MR Spectroscopy Detects Cerebral Hemodynamic Impairment in Patients With Unilateral Chronic Major Cerebral Artery Steno-Occlusive Disease Comparison With Positron Emission Tomography, Stroke 2009;40;3012-3016. https://doi.org/10.1161/STROKEAHA.109.555508
  19. Cady EB, D''Souza PC, Penrice J, Lorek A. The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy. Magn Reson Med 1995;33:862-7. https://doi.org/10.1002/mrm.1910330620
  20. Corbett RJ, Laptook AR, Tollefsbol G, Kim B. Validation of a noninvasive method to measure brain temperature in vivo using 1H NMR spectroscopy. J Neurochem 1995;64:1224-30.
  21. Woo D. C., et. al, Investigation of varied MR spectra by TE and metabolite amount in the localized voxel using the MR cone-shape phantom, medical physics, 18-3, 2007;179-185.
  22. Paik M.Y., The Development of Signal Processing Software for Single - and Multi - Voxel MR Spectroscopy, Journal of the Institute of Electronics Engineers of Korea, v.39 no.5, 544-555.
  23. Germain D, Chevallier P, Laurent A, Saint-Jalmes H. MR monitoring of tumour thermal therapy. Magn Reson Materials Phys Biol Med (MAGMA) 2001;13:47-59. https://doi.org/10.1007/BF02668650
  24. Woo D. C., et. al, Measurement and Assessment of Absolute Quantification from in Vitro Canine Brain Metabolites Using 500 MHz Proton Nuclear Magnetic Resonance Spectroscopy: Preliminary Results, KSMRM, 12-2, 2008, 100-106.