DOI QR코드

DOI QR Code

혈압조절을 위한 모선 제어되는 체내 이식형 전기 자극기의 개발 및 체외 성능 평가

Development and Estimation of a Wireless Controlled Implantable Electric-stimulator for the Blood Pressure Regulation

  • 김유석 (강원대학교 공과대학 기계의용공학과) ;
  • 박성민 (강원대학교 의학전문대학원) ;
  • 심은보 (강원대학교 공과대학 기계의용공학과) ;
  • 최성욱 (강원대학교 공과대학 기계의용공학과)
  • Kim, Yoo-Seok (Dept. of Mechanical and Biomedical Engineering, Kangwon National University) ;
  • Park, Seong-Min (School of Medicine, Kangwon National University) ;
  • Shim, Eun-Bo (Dept. of Mechanical and Biomedical Engineering, Kangwon National University) ;
  • Choi, Seong-Wook (Dept. of Mechanical and Biomedical Engineering, Kangwon National University)
  • 투고 : 2010.06.21
  • 심사 : 2010.09.06
  • 발행 : 2010.10.31

초록

Hypertension is the chronic disease that the 16% of total population are suffering, and it needs to be studied to find alternative treatment because of the tolerance and side effect of medications that may bother some patients. in this paper, we verified practicality of implantable electrical stimulator that can readily change stimulus magnitude and frequency. And this device is possible to stimulate baroreflex or parasympathetic nerve. Therefore we performed in vitro tests and animal experiment for device's operating conditions. This device consist of implantable electrical stimulator and extracorporeal control/monitoring system. Stimulator was designed to make 1Hz~100Hz pulses and it can change continuous or periodic pulse train type. And this device can control stimulator's function and monitor stimulator's status and patients' blood pressure at exterior of body using ZigBee module as wireless telecommunication. We verified that stimulator have error rate under 5% at 50mm depth of organs and, stimulator makes high-efficiency energy with closer position of two electrodes. Also we can confirm the performance of device that decreasing blood pressure and heart rate of a rat by electrical stimulation.

키워드

과제정보

연구 과제 주관 기관 : 한국연구재단

참고문헌

  1. Helio C. Salgado, A'lvaro R Barale, Jaci A. Castania, "Baroreflex responses to electrical stimulation of aortic depressor nerve in conscious SHR", Am J Physiol Heart Circ Physiol, 292, H593-H600, 2007. https://doi.org/10.1152/ajpheart.00181.2006
  2. Mancia, G Dell'Oro, Raffaella et al., "Angiotensin-sympathetic system interactions in cardiovascular and metabolic disease", Journal of Hypertension, vol 24, pp 51-56, 2006. https://doi.org/10.1097/01.hjh.0000198028.84353.86
  3. William V. Judy, Susan K. Farrell, 2009, "Arterial baroreceptor reflex control of sympathetic nerve activity in the spontaneously hypertensive rat", Journal of American Heart Association, vol 1, No 6, 605-614, 2009.
  4. Kerstin Wustmann, Jan P. Kucera, "Effects of Chronic Baroreceptor Stimulation on the Autonomic Cardiovascular Regulation in Patients With Drug-Resistant Arterial Hypertension", Journal of American Heart Association, 54, 530-536, 2009.
  5. J. P. Saul, R. D. Berger, P. Albrecht, S. P. Stein, M. H. Chen and R. J. Cohen, Transfer function analysis of the circulation: unique insights into cardiovascular regulation, Am J Physiol Heart Circ Physiol, 261, H1231-H1245, 1991.
  6. Hasser EM, Bishop VS, Hay M, Interactions Between Vasopressin and Barorflex control of the Sympathetic Nervous System, Clinical and Experimental Pharmacology and Physiology 24, 102-108, 1997. https://doi.org/10.1111/j.1440-1681.1997.tb01791.x
  7. James P. Fisher, Shigehiko Ogoh, Ellen A. Dawson, Paul J. Fadel, Niels H. Secher,Peter B. Raven and Michael J. White Cardiac and Vasomotor Component of the Carotid Baroreflex Control of Arterial Blood Pressure During Isometric Exercise in Humans, J. Physiol, 572, 869-880, 2006. https://doi.org/10.1113/jphysiol.2005.103028
  8. Jug Schmidli; Hannu Savolainen; Friedrich Eckstein; Eric Irwin; Tim K. Peters; Roy Martin; Robert Cody; Thierry Carrel, Acute Device-Based Blood Pressure Reduction: Electrical Activation of the Carotid Baroreflex in Patients Undergoing Elective Carotid Surgery, Vascular 15(2):63-69, 2007. https://doi.org/10.2310/6670.2007.00024
  9. Franchini KG, Moreira ED, Krieger EI, Krieger EM, Alterations in the cardiovascular control by the chemoreflex and the baroreflex in old rats, Am J Physiol Regul Integr Comp Physiol 270: R310-R313, 1996. https://doi.org/10.1152/ajpregu.1996.270.1.R310
  10. J. L. Prehn, J. A. Bevan, "Facial vein of the rabbit. Intracellularly recorded hyperpolarization of smooth muscle cells induced by beta-adrenergic receptor stimulation", Circulation Research, vol 52, pp. 465-470, 1983. https://doi.org/10.1161/01.RES.52.4.465
  11. Mancia, G Dell'Oro, Raffaella et al., "Angiotensin-sympathetic system interactions in cardiovascular and metabolic disease", Journal of Hypertension, vol 24, pp 51-56, 2006. https://doi.org/10.1097/01.hjh.0000198028.84353.86
  12. William V. Judy, Susan K. Farrell, 2009, "Arterial baroreceptor reflex control of sympathetic nerve activity in the spontaneously hypertensive rat", Journal of American Heart Association, 2009. vol 1, No 6, 605-614, 2009.
  13. Kerstin Wustmann, Jan P. Kucera, "Effects of Chronic Baroreceptor Stimulation on the Autonomic Cardiovascular Regulation in Patients With Drug-Resistant Arterial Hypertension", Journal of American Heart Association, 54;530-536, 2009.
  14. J. L. Prehn, J. A. Bevan, "Facial vein of the rabbit. Intracellularly recorded hyperpolarization of smooth muscle cells induced by beta-adrenergic receptor stimulation", Circulation Research, vol 52, pp. 465-470, 1983. https://doi.org/10.1161/01.RES.52.4.465
  15. H. J. Yun, Y. S. Yang, M. H. Ryu, J. J. Kim, N. G. Kim, A Remote Medical Treatment System for Stroke Recovery using ZigBee-Based Wireless Brain, J. Biomed. Eng. Res, Oct 028(05): 657-664, 2007.