Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

Increased B cell-activating factor (BAFF) level in the sputum of children with asthma

  • Jee, Hye-Mi (Department of Pediatrics, CHA University School of Medicine) ;
  • Choi, Bong-Seok (Department of Pediatrics, Institute of Allergy, Yonsei University College of Medicine) ;
  • Kim, Kyung-Won (Department of Pediatrics, Institute of Allergy, Yonsei University College of Medicine) ;
  • Sohn, Myung-Hyun (Department of Pediatrics, Institute of Allergy, Yonsei University College of Medicine) ;
  • Han, Man-Yong (Department of Pediatrics, CHA University School of Medicine) ;
  • Kim, Kyu-Earn (Department of Pediatrics, Institute of Allergy, Yonsei University College of Medicine)
  • 투고 : 2009.12.17
  • 심사 : 2010.02.20
  • 발행 : 2010.08.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naive cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary function, and bronchial hyperresponsiveness in children. Methods: One hundred and fifty-four asthmatic children and 98 healthy children were enrolled in the study. Sputum supernatants were collected and sputum BAFF and eosinophil cationic protein (ECP) levels were measured. We performed pulmonary function tests and methacholine challenge tests, while measuring total eosinophil count, total serum IgE, and serum ECP in all subjects. Results: Asthmatic children had significantly higher levels of BAFF in induced sputum [26.50 (10.50-100.27) pg/mL] compared to healthy children [18.32 (7.68-44.63) pg/mL; $P$=0.011]. Sputum BAFF positively correlated with sputum eosinophils (${\gamma}$=0.406, $P$<0.001) and sputum ECP (${\gamma}$=0.789, $P$<0.001). Significant negative correlations were found between sputum BAFF and FEV1 (${\gamma}$=-0.291, $P$<0.001) or post-bronchodilator FEV1 (${\gamma}$=-0.334, $P$<0.001), whereas nonsignificant correlations were found between sputum BAFF and bronchial hyperresponsiveness, serum eosinophil count, and serum ECP. Conclusion: These findings suggest that BAFF may play a role in childhood asthma, and BAFF levels in sputum could be a supportive marker that represents airway inflammation, especially eosinophilic inflammation.

키워드

참고문헌

  1. El Biaze M, Boniface S, Koscher V, Mamessier E, Dupuy P, Milhe F, et al. T cell activation, from atopy to asthma: more a paradox than a paradigm. Allergy 2003;58:844-53. https://doi.org/10.1034/j.1398-9995.2003.00282.x
  2. Lemanske RF Jr., Busse WW. 6. Asthma. J Allergy Clin Immunol 2003;111(2 Suppl):S502-19. https://doi.org/10.1067/mai.2003.94
  3. Mak TW, Yeh WC. Signaling for survival and apoptosis in the immune system. Arthritis Res 2002;4 Suppl 3:S243-52. https://doi.org/10.1186/ar569
  4. Huard B, Arlettaz L, Ambrose C, Kindler V, Mauri D, Roosnek E, et al. BAFF production by antigen-presenting cells provides T cell costimulation. Int Immunol 2004;16:467-75. https://doi.org/10.1093/intimm/dxh043
  5. Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, Casali P, et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 2002;3:822-9.
  6. Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol 2002;2:465-75. https://doi.org/10.1038/nri844
  7. Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, et al. Mice transgenic for BAFF develope lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999;190:1697-710. https://doi.org/10.1084/jem.190.11.1697
  8. Schiemann B, Gommerman JL, Vora K, Cachero TG, Shulga-Morskaya S, Dobles M, et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001;293:2111-4. https://doi.org/10.1126/science.1061964
  9. Huard B, Schneider P, Mauri D, Tschopp J, French LE. T cell costimulation by the TNF ligand BAFF. J Immunol 2001;167:6225-31. https://doi.org/10.4049/jimmunol.167.11.6225
  10. Kang JS, Yoon YD, Ahn JH, Kim SC, Kim KH, Kim HM, et al. B cell-activating factor is a novel diagnosis parameter for asthma. Int Arch Allergy Immunol 2006;141:181-8. https://doi.org/10.1159/000094897
  11. Matsushita T, Fujimoto M, Echigo T, Matsushita Y, Shimada Y, Hasegawa M, et al. Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis. Exp Dermatol 2008;17:197-202. https://doi.org/10.1111/j.1600-0625.2007.00642.x
  12. Moon EY, Ryu SK. TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice. Exp Mol Med 2007;39:343-52. https://doi.org/10.1038/emm.2007.38
  13. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-78. https://doi.org/10.1111/j.1398-9995.2004.00526.x
  14. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309-29. https://doi.org/10.1164/ajrccm.161.1.ats11-99
  15. Yoshikawa T, Shoji S, Fujii T, Kanazawa H, Kudoh S, Hirata K, et al. Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma. Eur Respir J 1998;12:879-84. https://doi.org/10.1183/09031936.98.12040879
  16. Yoon KA, Lim HS, Koh YY, Kim H. Normal predicted values of pulmonary function test in Korean school-aged children. J Korean Pediatr Soc 1993;36:25-37.
  17. Boulet LP, Turcotte H, Turcot O, Chakir J. Airway inflammation in asthma with incomplete reversibility of airflow obstruction. Respir Med 2003;97:739-44. https://doi.org/10.1053/rmed.2003.1491
  18. Covar RA, Spahn JD, Martin RJ, Silkoff PE, Sundstrom DA, Murphy J, et al. Safety and application of induced sputum analysis in childhood asthma. J Allergy Clin Immunol 2004;114:575-82. https://doi.org/10.1016/j.jaci.2004.06.036
  19. Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2008;121:1385-92, 92 e1-2. https://doi.org/10.1016/j.jaci.2008.03.002
  20. Sutherland AP, Ng LG, Fletcher CA, Shum B, Newton RA, Grey ST, et al. BAFF augments certain Th1-associated inflammatory responses. J Immunol 2005;174:5537-44. https://doi.org/10.4049/jimmunol.174.9.5537
  21. Gleich GJ. Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000;105:651-63. https://doi.org/10.1067/mai.2000.105712

피인용 문헌

  1. The effects of rituximab on serum IgE and BAFF vol.9, pp.1, 2013, https://doi.org/10.1186/1710-1492-9-39
  2. The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF) vol.15, pp.None, 2010, https://doi.org/10.1186/1471-2172-15-22
  3. Role of BAFF in pediatric patients with allergic rhinitis during sublingual immunotherapy vol.173, pp.8, 2010, https://doi.org/10.1007/s00431-014-2287-5
  4. Increased BAFF expression in nasal polyps is associated with local IgE production, Th2 response and concomitant asthma vol.274, pp.4, 2010, https://doi.org/10.1007/s00405-016-4435-1
  5. ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α–Endoplasmic Reticulum Stress–Beclin1 Autophagy Regulatory Pathway vol.199, pp.5, 2017, https://doi.org/10.4049/jimmunol.1602124
  6. Associations of Immunological Markers and Anthropometric Measures with Linear and Nonlinear Electrohysterographic Parameters at Term Active Labor vol.7, pp.1, 2018, https://doi.org/10.3233/nib-170127
  7. Autoimmune Responses in Severe Asthma vol.10, pp.5, 2010, https://doi.org/10.4168/aair.2018.10.5.428
  8. B cell-activating factor (BAFF) in children with inflammatory bowel disease vol.89, pp.7, 2010, https://doi.org/10.1038/s41390-020-01155-1