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Late physical effects of childhood cancer survivors

  • Lee, Young-Ho (Department of Pediatrics, Hanyang University College of Medicine)
  • Received : 2010.03.07
  • Accepted : 2010.03.18
  • Published : 2010.04.15

Abstract

Advances in research and medical and supportive care have contributed to a growing population of adults formerly treated for childhood cancer. History of cancer and its therapy can have significant life-long health implications. Late effects of cancer therapy can be insidious on onset, occur outside the pediatric age, and contribute to premature morbidity and mortality. In this review, I have focused on the key long-term effects of pediatric cancer therapy, particularly on the metabolic syndrome, including cardiopulmonary complications, infertility, and secondary neoplasm.

Keywords

References

  1. Gatta G, Zigon G, Capocaccia R, Coebergh JW, Desandes E, Kaatsch P, et al. Survival of European children and young adults with cancer diagnosed 1995-2002. Eur J Cancer 2009; 8:784-96.
  2. Oeffinger KC, Mertens AC, Hudson MM, Gurney JG, Casillas J, Chen H, et al. Health care of young adult survivorsof childhood cancer: A report from the Childhood Cancer Survivor Study. Ann Fam Med 2004;2:61-70. https://doi.org/10.1370/afm.26
  3. Kadan-Lottick NS, Robison LL, Gurney JG, Neglia JP, Yasui Y, Hayashi R, et al. Childhood cancer survivors knowledge about their past diagnosis and treatment: Childhood Cancer Survivor Study. JAMA 2002;287:1832-9. https://doi.org/10.1001/jama.287.14.1832
  4. Nathan PC, Greenberg ML, Ness KK, Hudson MM, Mertens AC, Mahoney MC, et al. Medical care in long-term survivorsof childhood cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol 2008;26:4401-9. https://doi.org/10.1200/JCO.2008.16.9607
  5. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new world-wide definition: A consensus statement from the International Diabetes Federation. Diabet Med 2006;23:469- 80. https://doi.org/10.1111/j.1464-5491.2006.01858.x
  6. Despr s JP, Lemieux I. Abdominal e obesity and metabolic syndrome. Nature 2006;444:881-7. https://doi.org/10.1038/nature05488
  7. Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol 2008;28:629-36. https://doi.org/10.1161/ATVBAHA.107.151092
  8. Gami AS, Witt BJ, Howard DE, Erwin PJ, Gami LA, Somers VK, et al. Metabolic syndrome and risk of incident cardiovascular events and death: A systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007;49:403-14. https://doi.org/10.1016/j.jacc.2006.09.032
  9. Trimis G, Moschovi M, Papassotiriou I, Chrousos G, Tzortzatou-Stathopoulou F. Early indicators of dysmetabolic syndrome in young survivors of acute lymphoblastic leukemia in childhood as a target for preventing disease. J Pediatr Hematol Oncol 2007;29:309-14. https://doi.org/10.1097/MPH.0b013e318059c249
  10. van Waas M, Neggers SJ, van der Lelij AJ, Pieters R, van den Heuvel-Eibrink MM. The Metabolic Syndrome in Adult Survivors of Childhood Cancer, a Review. J Pediatr Hematol Oncol 2010 Mar 11. [Epub ahead of print]
  11. Ko MS, Kim JY, Lim YJ, Lee YH, An HS, Yoo JH, et al. Patterns of obesity during anticancer chemotherapy in children with acute lymphoblastic leukemia. Korean J Hematol 2008;43:77-82. https://doi.org/10.5045/kjh.2008.43.2.77
  12. Lee YJ, Kim YH, Hah JO. Prevalence of obesity and cardiovascular risk factors in survivors of childhood acute lymphoblastic leukemia. Korean J Pediatr Hematol Oncol 2003;10:198-205.
  13. Lee JH, Seo HJ, Kim JY, Ko CW, Lee KS. Late endocrine complications in childhood cancer survivors. Korean J PediatrHematol Oncol 2005;12:55-62.
  14. Boot AM, Engels MA, Boerma GJ, Krenning EP, De Muinck Keizer-Schrama SM. Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency. J Clin Endocrinol Metab 1997;82:2423-8. https://doi.org/10.1210/jc.82.8.2423
  15. Binnerts A, Deurenberg P, Swart GR, Lamberts SW. Body composition in growth hormone-deficient adults. Am J Clin Nutr 1992;55:918-23.
  16. de Boer H, Blok GJ, Voerman HJ, Phillips M, Schouten JA. Serum lipid levels in growth hormone-deficient men. Metabolism 1994;43:199-203. https://doi.org/10.1016/0026-0495(94)90245-3
  17. Angelin B, Olivecrona H, Ericsson S, Rudling M. Growth hormone and low-density lipoproteins. Acta Endocrinol 1993;128(Suppl 2):26S8S.
  18. Eden S, Wiklund O, Oscarsson J, Rosen T, Bengtsson BA. Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations. Arterioscler Thromb 1993;13: 296-301. https://doi.org/10.1161/01.ATV.13.2.296
  19. Johansson JO, Fowelin J, Landin K, Lager I, Bengtsson BA. Growth hormone deficient adults are insulin-resistant. Metabolism 1995;44:1126-9. https://doi.org/10.1016/0026-0495(95)90004-7
  20. Roman J, Villaizan CJ, Garcia-Foncillas J, Azcona C, Salvador J, Sierrasesumaga L. Chemotherapy-induced growth hormone deficiency in children with cancer. Medical Pediatr Oncol 1995;25:90-5. https://doi.org/10.1002/mpo.2950250208
  21. Stava CJ, Jimenez C, Vassilopoulou-Sellin R. Endocrine sequelae of cancer and cancer treatments. J Cancer Surviv 2007;1:261-74. https://doi.org/10.1007/s11764-007-0038-6
  22. Tukenova M, Guibout C, Oberlin O, Doyon F, Mousannif A, Haddy N, et al. Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J Clin Oncol 2010;28:1308-15. https://doi.org/10.1200/JCO.2008.20.2267
  23. van Dalen EC, Caron HN, Kremer LC. Prevention of anthracycline-induced cardiotoxicity in children: The evidence. Eur J Cancer 2007;43:1134-40. https://doi.org/10.1016/j.ejca.2007.01.040
  24. Liles A, Blatt J, Morris D, Wardrop R 3rd, Sharma A, Sznewajs A, et al. Monitoring pulmonary complications in long-term childhood cancer survivors: Guidelines for the primary care physician. Cleve Clin J Med 2008;75:531-9. https://doi.org/10.3949/ccjm.75.7.531
  25. Bhatia S, Constine LS. Late morbidity after successful treatment of children with cancer. Cancer J 2009;15:174-80. https://doi.org/10.1097/PPO.0b013e3181a58f46
  26. Sanders JE, Buckner CD, Leonard JM, Sullivan KM, Witherspoon RP, Deeg HJ, et al. Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation. Transplantation 1983;36:252-5. https://doi.org/10.1097/00007890-198309000-00005
  27. Meadows AT, Friedman DL, Neglia JP, Mertens AC, Donaldson SS, Stovall M, et al. Second neoplasms in survivors of childhood cancer: Findings from the Childhood Cancer Survivor Study cohort. J Clin Oncol 2009;27:2356-62. https://doi.org/10.1200/JCO.2008.21.1920
  28. Bhatia S, Robison LL, Oberlin O, Greenberg M, Bunin G, Fossati-Bellani F, et al. Breast cancer and other second neoplasms after childhood Hodgkins disease. N Engl J Med 1996;334:745-51. https://doi.org/10.1056/NEJM199603213341201