PREVENTIVE EFFECT OF ADHESIVE TAPE SUPPLEMENTED WITH NaF ON ENAMEL EROSION IN VITRO

불소함유 접착테잎의 법랑질 침식 예방효과

  • 이상호 (조선대학교 치의학전문대학원) ;
  • 이난영 (조선대학교 치의학전문대학원) ;
  • 이인화 (조선대학교 공과대학 환경공학과)
  • Published : 2010.02.26

Abstract

This study examined the effect of adhesive tape supplemented with sodium fluoride on the prevention of dental erosion in vitro. Sound bovine tooth samples were selected and divided randomly into the following 4 groups according to the material treatments: group 1, APF gel; group 2, fluoride varnish; and groups 3 and 4, fluoride tape supplemented with 5% NaF in either a methyl cellulose or poly vinyl acetate carrier, respectively. All specimens were submitted to alternate cycles of acid exposure in a cola beverage (pH 4.3) and artificial saliva for $6\;{\times}\;5\;min/day$ over a 5 day period. The micro-hardness was recorded each day and the lesion depth was measured after 5 days. The micro-hardness of the experimental sides of groups 2, 3 and 4 were significantly higher than that of their control sides and the experimental side of group 1 during the experimental period (p<0.05) except on the 5th day. The enamel surfaces of treatment groups 2, 3 and 4 showed significantly higher resistance to mineral loss in terms of the erosion depth (p<0.05) than group 1 and their control sides. There was no statistically significant difference among group 2, 3 and 4, indicating that the fluoride varnish and tapes produce similar results. Fluoride adhesive tapes are effective in reducing the progression of erosion and can be recommended for young patients who are more susceptible to dental erosion.

본 연구는 불소함유 접착테잎의 법랑질 침식 예방효과를 평가하기 위해건강한 소의 치아를 절단하여 아크릴 주형에 매몰하고 정중선에 홈을 형성하여 대조면과 불소 제제를 도포할 실혐면으로 나누었다. 시편을 무작위로 18개씩 4군으로 나누었다. 1군은 APF gel를 도포하고, 2군은 불소 바니쉬를 도포하였으며, 3군과 4군은 5% NaF를 각각 첨가한 methyl cellulose와 poly vinyl alcohol 테잎을 부착하였다. 시편을 콜라에 5분, 증류수에 10분씩 6회 번갈아 처리하며 5일 동안 반복하였다. 시간 경과에 따라 표면미세경도를 측정하고 5일후 각 시편을 절단하여 침식병소의 깊이를 측정하여 다음과 같은 결과를 얻었다. 1. 표면미세경도 값은 5일째만 제외하고 2군, 3군, 4군의 실험면이 각각의 대조면에 비해 컸다 (p<0.05). 2군, 3군, 4군의 실험면 역시 5일째만 제외하고 1군의 실험면에 비해 표면미세경도가 컸다 (p<0.05). 3군과 4군 사이에는 표면미세 경도의 유의한 차이가 없었다(p>0.05). 1군의 실험면과 대조면은 표면미세경도의 유의차가 없었다(p>0.05). 2. 침식병소의 깊이는 2군, 3군, 4군의 실험면이 각각의 대조면에 비해 컸다(p<0.05). 2군, 3군, 4군의 실험면은 1군의 실험면에 비해 침식병소의 깊이가 얕았다 (p<0.05). 2군, 3군, 4군의 실험면 사이의 침식병소의 깊이는 유의차가 없었다(p>0.05). 상기 결과로 보아 새로 개발된 불소함유 접착테잎은 기존의 불소 바니쉬와 같은 법랑질 침식 예방효과가 분명하게 나타나, 법랑질 침식에 감수성이 높은 어린이 환자에게 임상적인 예방법으로서 활용할 수 있는 가능성이 높다고 사료된다.

Keywords

References

  1. Lussi A, Schaffner M, Hotz P, et al. : Dental erosion in a population of Swiss adults. Community Dent Oral Epidemiol, 19:286-290, 1991. https://doi.org/10.1111/j.1600-0528.1991.tb00169.x
  2. Dugmore CR, Rock WP : The prevalence of tooth erosion in 12-year-old children. Br Dent J, 196:279-282, 2004. https://doi.org/10.1038/sj.bdj.4811040
  3. Al-Majed I, Maquire A, Murray JJ : Risk factor for dental erosion in %-6 year old and 12-14 year old boys in Saudi Arabia. Community Dent Oral Epidemiol, 30:38-46, 2002. https://doi.org/10.1034/j.1600-0528.2002.300106.x
  4. Harding MA, Whelton H, O'Mullane DM, et al. : Dental erosion in 5-year-old Irish school children and associated factors: a pilot study. Community Dent Health, 20:165-170, 2003.
  5. Jarvinen VK, Rytomaa II, Heinonen OP : Risk factors in dental erosion. J Dent Res, 70:942-947, 1991. https://doi.org/10.1177/00220345910700060601
  6. Magalhães AC, Wiegand A, Rios D, et al.: Insights into preventive measures for dental erosion. J Appl Oral Sci, 17:75-86, 2009.
  7. Imfeld T : Dental erosion. Definition, classification and links. Eur J Oral Sci, 104:151-155, 1996. https://doi.org/10.1111/j.1600-0722.1996.tb00063.x
  8. Addy M, Absi EG, Adams D : Dentin hypersensitivity. The effects in vitro of acids and dietary substances on root planed and burred dentine. J Clin Periodontol, 14:274-279, 1987. https://doi.org/10.1111/j.1600-051X.1987.tb01532.x
  9. Grobler SR, Senekal PJ, Laubscher JA : In vitro demineralization of enamel by orange juice, apple juice, Pepsi Cola and Diet Pepsi Cola. Clin Prev Dent, 12:5-9, 1990.
  10. Meurman JH, Harkonen M, Naveri H, et al. : Experimental sports drinks with minimal dental erosion effect. Scand J Dent Res, 98:120-128, 1990.
  11. Owens BM, Kitchens M: The erosive potential of soft drinks on enamel surface substrate: an in vitro scanning electron microscopy investigation. J Contemp Dent Pract, 8:11-20, 2007.
  12. Wongkhantee S, Patanapiradej V, Maneenut C, et al. : Effect of acidic food and drinks on surface hardness of enamel, dentine, and tooth-coloured filling materials. J Dent, 34:214-220, 2006. https://doi.org/10.1016/j.jdent.2005.06.003
  13. Ehlen LA, Marshall TA, Qian F, et al. : Acidic beverages increase the risk of in vitro tooth erosion. Nutr Res, 28:299-303, 2008. https://doi.org/10.1016/j.nutres.2008.03.001
  14. Edwards M, Creanor SL, Foye RH, et al: Buffering capacities of soft dinks: the potential influence on dental erosion. J Oral Rehabil, 26:923-927, 1999. https://doi.org/10.1046/j.1365-2842.1999.00494.x
  15. 장기택 : 수종 음료수의 법랑질과 상아질침식에 관한 연구. 대한소아치과학회지, 24:719-726, 1997.
  16. 김정욱 : 산성 음료수에 의한 법랑질 침식과 구강 내 재경화에 관한 연구. 대한소아치과학회지, 25:312-322, 1998.
  17. Ireland AJ, McGuiness N, Sherriff M : An investigation into the ability of soft drinks to adhere to enamel. Caries Res, 29:470-476, 1995. https://doi.org/10.1159/000262117
  18. Vasir JK, Tambwekar K, Garg S : Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm, 255:13-32, 2003. https://doi.org/10.1016/S0378-5173(03)00087-5
  19. McKnight-Hanes C, Whitford GM : Fluoride release from three glass ionomer materials and the effects of varnishing with or without finishing. Caries Res, 26:345-350, 1992. https://doi.org/10.1159/000261466
  20. Jensen ME, Donly K, Wefel JS : Assessment of the effect of selected snack foods on the remineralization/ demineralization of enamel and dentin. J Contemp Dent Pract, 1:1-17, 2000.
  21. Larsen MJ, Richards A : Fluoride is unable to reduce dental erosion from soft drinks. Caries Res, 36 : 75-80, 2002. https://doi.org/10.1159/000057595
  22. Hughes JA, West NX, Addy M : The protective effect of fluoride treatments against enamel erosion in vitro. J Oral Rehabil, 31, 357-363, 2004. https://doi.org/10.1046/j.1365-2842.2003.01240.x
  23. Sorvari R, Meurman JH, Alakuijada P, et al. : Effect of fluoride varnish and solution on enamel erosion in vitro. Caries Res, 28:227-232, 1994. https://doi.org/10.1159/000261970
  24. Kitchens M, Owens BM : Effect of carbonated beverages, coffee, sport and high energy drinks, and bottled water on the in vitro erosion characteristics of dental Enamel. J Clin Pediatr Dent, 31:153-159, 2007.
  25. Graubart J, Gedalia I, Pisanti S : Effects of Fluoride Pretreatment in vitro on Human Teeth Exposed to Citrus Juice. J Dent Res, 51:1677, 1972. https://doi.org/10.1177/00220345720510063301
  26. Larsen MJ: Prevention by means of fluoride of enamel erosion as caused by soft drinks and orange juice. Caries Res, 35:229-234, 2001. https://doi.org/10.1159/000047461
  27. Van Rijkom H, Ruben J, Vieira A, et al. : Erosioninhibiting effect of sodium fluoride and titanium tetrafluoride treatment in vitro. Eur J Oral Sci 111:253-257, 2003. https://doi.org/10.1034/j.1600-0722.2003.00031.x
  28. Munoz CA, Feller R, Haglund A, et al. : Strengthening of tooth enamel by a remineralizing toothpaste after exposure to an acidic soft drink. J Clin Dent, 10:17-21, 1999.
  29. Vieira A, Ruben JL, Huysmans MC : Effect of titanium tetrafluoride, amine fluoride and fluoride varnish on enamel erosion in vitro. Caries Res, 39:371-379, 2005. https://doi.org/10.1159/000086843
  30. Seppa L : Effects of a sodium fluoride solution and a varnish with different fluoride concentrations on enamel remineralization in vitro. Scand J Dent Res, 96:304-309, 1988.
  31. von Fraunhofer JA, Rogers MM : Dissolution of dental enamel in soft drinks. Gen Dent, 52:308-312, 2004.
  32. Featherstone JD, Mellberg JR : Relative rates of progress of artificial carious lesions in bovine, ovine and human enamel. Cares Res, 15:109-114, 1981. https://doi.org/10.1159/000260508
  33. Wegehaupt F, Gries D, Wiegand A, et al. : Is bovine dentine an appropriate substitute for human dentine in erosion/abrasion tests? J Oral Rehabil, 35:390-394, 2008. https://doi.org/10.1111/j.1365-2842.2007.01843.x
  34. Meurman JH, Rytomaa I, Kari K, et al. : Salivary pH and glucose after consuming various beverages, including sugar-containing drinks. Caries Res, 21:353-359, 1987. https://doi.org/10.1159/000261039
  35. Ganss C, Klimek J, Schaffer U, et al. : Effectiveness of two fluoridation measures on erosion progression in human enamel and dentine in vitro. Caries Res, 35:325-330, 2001. https://doi.org/10.1159/000047470
  36. Millward A, Shaw L, Harrington E, et al. : Continuous monitoring of salivary flow rate and pH at the surface of the dentition following consumption of acidic beverages. Caries Res, 31:44-49, 1997. https://doi.org/10.1159/000262373
  37. ten Cate JM, Imfeld T: Dental erosion, summary. Eur J Oral Sci, 104:241-244, 1996. https://doi.org/10.1111/j.1600-0722.1996.tb00073.x
  38. Imfeld T : Prevention of progression of dental erosion by professional and individual prophylactic measures. Eur J Oral Sci, 104:215-222, 1996. https://doi.org/10.1111/j.1600-0722.1996.tb00070.x
  39. Wei Shy, wefel JS : In vitro interactions between the surfaces of enamel white spots and calcifying solutions. J Dent Res, 55:135-141, 1976. https://doi.org/10.1177/00220345760550010601
  40. Nelson DG, Jongebloed WL, Arends J : Morphology of enamel surfaces treated with topical fluoride agents: SEM considerations. J Dent Res, 62:1201-1208, 1983. https://doi.org/10.1177/00220345830620120501
  41. Petersson LG : Fluoride mouthrinse and fluoride varnishes. Caries Res, 27:35-42, 1993. https://doi.org/10.1159/000261600