한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제27권1호
  • /
  • Pages.35-41
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  • 2010
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

위탁견에서 스트레스에 의한 혈중 Cortisol의 농도 변화

Changes in Serum Cortisol Concentration Due to Boarding Stress in Dogs

  • 이상길 (인제대학교 의생명공학대학, 심혈관 및 대사성질환 센터) ;
  • 송인수 (경상대학교 수의과대학, 동물의학연구소) ;
  • 박수경 (인제대학교 의생명공학대학, 심혈관 및 대사성질환 센터) ;
  • 홍용근 (인제대학교 의생명공학대학, 심혈관 및 대사성질환 센터) ;
  • 강정부 (경상대학교 수의과대학, 동물의학연구소)
  • Lee, Sang-Kil (Cardiovascular & Metabolic Disease Center, College of Biomedical Science and Engineering, Inje University) ;
  • Song, In-Soo (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Park, Soo-Kyoung (Cardiovascular & Metabolic Disease Center, College of Biomedical Science and Engineering, Inje University) ;
  • Hong, Yong-Geun (Cardiovascular & Metabolic Disease Center, College of Biomedical Science and Engineering, Inje University) ;
  • Kang, Chung-Boo (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 발행 : 2010.02.28
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초록

Among the dogs boarding at an animal hospital, 10 dogs each were selected as a free boarding group and a kennel boarding group. Each group was further divided into 5 puppies and 5 mature dogs to examine the changes in their serum cortisol concentrations during boarding (5 days). We collected blood at day 8 and then analyzed the blood corpuscles, ran a biochemical serum test, and an additional urine test before boarding to check their health status. After collecting the dog's blood at 9:00 am, 3:00 pm, and 9:00 pm, we analyzed the cortisol concentration by the radioimmunoassay (RIA) method. The daily serum cortisol concentration at 9:00 am, 3:00 pm, and 9:00 pm, had a circadian rhythm during both the free and kennel boarding periods in both puppies and adults. Furthermore, the average daily serum cortisol concentration was significantly increased during the 1st, 2nd, and 3rd day after free boarding in the puppy group (P < 0.01). In adults from the free boarding group, the serum cortisol concentration dramatically increased on the 1st day (P < 0.01), as well as on the 2nd and 3rd day (P < 0.05). Interestingly, the average daily serum cortisol concentration was significantly increased on the 1st day after kennel boarding as well as during the entire period of kennel boarding in the puppy group (P < 0.05). In the adult kennel boarding group, serum cortisol concentration was significantly increased during the whole kennel boarding period (P < 0.01). An interesting result was that circadian rhythmicity in the sum of the daily serum cortisol concentrations was present in the free boarding group, but not in the kennel boarding group in both puppies and adults. In summary, cortisol was released depending on the degree of stress in free and kennel boarded dogs. Taken together, these results suggest that cortisol, a stress hormone, should be maintained at physiological concentrations in a circadian rhythm when the animals are hospitalized.

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