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Development of De Novo Cavernous Hemangioma after Radiosurgery for Cavernous Hemangioma

  • Yeon, Je-Young (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Suh, Yeon-Lim (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Jong-Hyun (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Jung-Il (Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2010.03.31
  • Accepted : 2010.12.31
  • Published : 2010.12.28

Abstract

We report a rare case of cavernous hemangioma (CH) which developed in adjacent location to a preexisting CH after gamma knife radiosurgery (GKRS). A 36-year-old woman underwent GKRS for a CH in the left lentiform nucleus. Three-and-half years after radiosurgery, MRI revealed a new CH in the left caudate nucleus. Surgical excision of the new lesion was performed. The pathological examination confirmed the diagnosis of CH. In radiosurgery for CH, it should be noted that a new CH may develop, which is likely to result from the interaction between radiation and predisposing factors of the patient.

Keywords

References

  1. Hasegawa T, McInerney J, Kondziolka D, Lee JY, Flickinger JC, Lunsford LD : Longterm results after stereotactic radiosurgery for patients with cavernous malformations. Neurosurgery 50 : 1190-1197; discussion 1197-1198, 2002
  2. Heckl S, Aschoff A, Kunze S : Radiation-induced cavernous hemangiomas of the brain : a late effect predominantly in children. Cancer 94 : 3285-3291, 2002 https://doi.org/10.1002/cncr.10596
  3. Iwai Y, Yamanaka K, Yoshimura M: Intracerebral cavernous malformation induced by radiosurgery. Case report. Neurol Med Chir (Tokyo) 47 : 171-173, 2007 https://doi.org/10.2176/nmc.47.171
  4. Jung JM, Kim JS, Kim KJ, Hwang SH, Park IS, Kim ES, et al. : Intracranial cavernous hemangioma after radiotherapy for astrocytoma. Case report. J Korean Neurosurg Soc 30 : 1324-1327, 2001
  5. Larson JJ, Ball WS, Bove KE, Crone KR, Tew JM, Jr. : Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children. J Neurosurg 88 : 51-56, 1998 https://doi.org/10.3171/jns.1998.88.1.0051
  6. Leblanc GG, Golanov E, Awad IA, Young WL : Biology of vascular malformations of the brain. Stroke 40 : e694-e702, 2009
  7. Motegi H, Kuroda S, Ishii N, Aoyama H, Terae S, Shirato H, et al. : De novo formation of cavernoma after radiosurgery for adult cerebral arteriovenous malformation--case report. Neurol Med Chir (Tokyo) 48 : 397-400, 2008 https://doi.org/10.2176/nmc.48.397
  8. Nimjee SM, Powers CJ, Bulsara KR : Review of the literature on de novo formation of cavernous malformations of the central nervous system after radiation therapy. Neurosurg Focus 21 : e4, 2006
  9. Noel L, Christmann D, Jacques C, Kehrli P, Grebici-Guessom M, Esposito P, et al. : [Intracerebral radiation-induced cavernous angiomas]. J Neuroradiol 29 : 49-56, 2002
  10. Novelli PM, Reigel DH, Langham Gleason P, Yunis E : Multiple cavernous angiomas after high-dose whole-brain radiation therapy. Pediatr Neurosurg 26 : 322-325, 1997 https://doi.org/10.1159/000121213
  11. Pozzati E, Acciarri N, Tognetti F, Marliani F, Giangaspero F : Growth, subsequent bleeding, and de novo appearance of cerebral cavernous angiomas. Neurosurgery 38 : 662-669; discussion 669-670, 1996 https://doi.org/10.1227/00006123-199604000-00006
  12. Sasagawa Y, Akai T, Itou S, Iizuka H : Gamma knife radiosurgeryinduced cavernous hemangioma : case report. Neurosurgery 64 : E1006-E1007; discussion E1007, 2009 https://doi.org/10.1227/01.NEU.0000344005.23146.CC

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