What is Environmental Disease? - Psychiatric Perspectives -

환경성 질환이란 무엇인가? - 정신과적 관점 -

  • Kim, Jae-Won (Department of Psychiatry, Seoul National University College of Medicine)
  • 김재원 (서울대학교 의과대학 정신과학교실)
  • Received : 2010.10.15
  • Accepted : 2010.12.14
  • Published : 2010.12.31

Abstract

In this review, we give an overview of psychiatric perspectives on environmental disease. The concept of genetic heritability and its meaning with regard to environmental risk factors will be discussed. Recent ideas of gene-environment interaction and neurodevelopmental disorder in psychiatry will also be introduced. This article discusses the environmental risk factors for attention deficit hyperactivity disorder (ADHD) and autism, the two major environmental diseases and neurodevelopmental disorders in psychiatry. Given that both ADHD and autism are complex conditions, the etiology is likely to involve multiple genes of moderate effect interacting with environmental factors. We will introduce recent environmental issues related to these two disorders.

Keywords

References

  1. Bray GA. Leptin and leptinomania. Lancet 1996; 348(9021): 140-141. https://doi.org/10.1016/S0140-6736(05)66103-X
  2. McGuffin P, Riley B, Plomin R. Genomics and behavior. Toward behavioral genomics. Science 2001; 291(5507): 1232-1249. https://doi.org/10.1126/science.1057264
  3. Makris N, Biederman J, Monuteaux MC, Seidman LJ. Towards conceptualizing a neural systems-based anatomy of attention-deficit/hyperactivity disorder. Dev Neurosci 2009; 31(1-2): 36-49. https://doi.org/10.1159/000207492
  4. Eskenazi B, Castorina R. Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children. Environ Health Perspect 1999; 107(12): 991-1000. https://doi.org/10.1289/ehp.99107991
  5. Mendola P, Selevan SG, Gutter S, Rice D. Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment Retard Dev Disabil Res Rev 2002; 8(3): 188-197. https://doi.org/10.1002/mrdd.10033
  6. Bishop D, Rutter M. Neurodevelopmental disorders: conceptual issues. Rutter's Child and Adolescent Psychiatry. 5th ed: Blackwell Publishing; 2008. p. 32-41.
  7. Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet 2005; 366(9481): 237-248. https://doi.org/10.1016/S0140-6736(05)66915-2
  8. Banerjee TD, Middleton F, Faraone SV. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 2007; 96(9): 1269-1274. https://doi.org/10.1111/j.1651-2227.2007.00430.x
  9. Singh I. Beyond polemics: science and ethics of ADHD. Nat Rev Neurosci 2008; 9(12): 957-964. https://doi.org/10.1038/nrn2514
  10. Kim BN, Cho SC, Kim Y, Shin MS, Yoo HJ, Kim JW, et al. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Biol Psychiatry 2009; 66(10): 958-963. https://doi.org/10.1016/j.biopsych.2009.07.034
  11. Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM, et al. Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 2009; 117(12): 1945-1952. https://doi.org/10.1289/ehp.0900979
  12. Ha M, Kwon HJ, Lim MH, Jee YK, Hong YC, Leem JH, et al. Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: a report of the children's health and environment research (CHEER). Neurotoxicology 2009; 30(1): 31-36. https://doi.org/10.1016/j.neuro.2008.11.011
  13. Kim Y, Cho SC, Kim BN, Hong YC, Shin MS, Yoo HJ, et al. Association between blood lead levels (<5 ${\mu}g$/dL) and inattention-hyperactivity and neurocognitive profiles in school-aged Korean children. Sci Total Environ 2010; 408(23): 5737-5743. https://doi.org/10.1016/j.scitotenv.2010.07.070
  14. Williams JH, Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry 2007; 16(4): 243-253. https://doi.org/10.1007/s00787-006-0596-6
  15. Pardo CA, Eberhart CG. The neurobiology of autism. Brain Pathol 2007; 17(4): 434-447. https://doi.org/10.1111/j.1750-3639.2007.00102.x
  16. Rutter M. Incidence of autism spectrum disorders: changes over time and their meaning. Acta Paediatr 2005; 94(1): 2-15. https://doi.org/10.1080/08035250410023124
  17. Bertoglio K, Hendren RL. New developments in autism. Psychiatr Clin North Am 2009; 32(1): 1-14. https://doi.org/10.1016/j.psc.2008.10.004
  18. Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S, et al. Enterocolitis in children with developmental disorders. Am J Gastroenterol 2000; 95(9): 2285-2295. https://doi.org/10.1111/j.1572-0241.2000.03248.x
  19. Palmer RF, Blanchard S, Stein Z, Mandell D, Miller C. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. Health Place 2006; 12(2): 203-209. https://doi.org/10.1016/j.healthplace.2004.11.005
  20. Chauhan A, Chauhan V. Oxidative stress in autism. Pathophysiology 2006; 13(3): 171-181. https://doi.org/10.1016/j.pathophys.2006.05.007
  21. Kolevzon A, Gross R, Reichenberg A. Prenatal and perinatal risk factors for autism: a review and integration of findings. Arch Pediatr Adolesc Med 2007; 161(4): 326-333. https://doi.org/10.1001/archpedi.161.4.326
  22. Dengate S, Ruben A. Controlled trial of cumulative behavioural effects of a common bread preservative. J Paediatr Child Health 2002; 38(4): 373-376. https://doi.org/10.1046/j.1440-1754.2002.00009.x
  23. Pollock I, Warner JO. Effect of artificial food colours on childhood behaviour. Arch Dis Child 1990; 65(1): 74-77. https://doi.org/10.1136/adc.65.1.74