한국군사과학기술학회지 (Journal of the Korea Institute of Military Science and Technology)

  • 제13권4호
  • /
  • Pages.689-698
  • /
  • 2010
  • /
  • 1598-9127(pISSN)
  • /
  • 2636-0640(eISSN)
한국군사과학기술학회 (The Korea Institute of Military Science and Technology)
권호 표지

전투피로 완화를 위한 정신약물의 활용에 관한 연구

Studies on Application of Psychoactive Drugs for Relieving of Combat Fatigue

  • 투고 : 2010.05.07
  • 심사 : 2010.07.23
  • 발행 : 2010.08.05
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Fatigue has been a common symptom of warfighters who were participated in the early morning hours, late night hours, and sustained operations. Continuous operations may disrupt circadian rhythm, resulting in impaired combat capability. It is important to enhance alertness and sleep quality of warfighters for maintaining combat capability. A number of anti-fatigue strategies are available including medications. Here in, the pharmacological countermeasures of combat fatigue have reviewed, and the direction of research in the pharmacological countermeasures against combat fatigue are proposed.

키워드

참고문헌

  1. Arendt J T, Skene D J, Melatonin as a Chronobiotic, Sleep Med Rev, 9, pp. 25-39, 2005. https://doi.org/10.1016/j.smrv.2004.05.002
  2. Batejat D, Coste O, Van Beers P, Lagarde D, Pierard C, Beaumont M, Prior Sleep with Zolpidem Enhances the Effect of Caffeine or Modafinil During 18 Hours Continuous Work, Aviat Space Environ Med. 77(5), pp. 515-25, 2006.
  3. Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, et al, Effects of Exogenous Melatonin on Sleep : A Meta-analysis, Sleep Med Rev, 9, pp. 41-50, 2005. https://doi.org/10.1016/j.smrv.2004.06.004
  4. Caldwell J A, Caldwell J L, Crowley J S, Jones H D, Sustaining Helicopter Pilot Performance with Dexedrine During Periods of Sleep Deprivation, Aviat Space Environ Med. 66(10), pp. 930-937, 1995.
  5. Caldwell J A, Caldwell J L, Comparison of the Effects of Zolpidem Induced Prophylactic Naps to Placebo Naps and Forced Rest Periods in Prolonged Work Schedules, Sleep, 21, pp. 79-90, 1998. https://doi.org/10.1093/sleep/21.1.79
  6. Caldwell J A, Smythe N K, Leduc P A, Caldwell J L, Efficacy of Dexedrine for Maintaining Aviator Performance During 64 Hours of Sustained Wakefulness : A Simulator Study, Aviat Space Environ Med. 71(1), pp. 7-18, 2000.
  7. Caldwell J A, Caldwell J L, Smith J K, Brown D L, Modafinil's Effects on Simulator Performance and Mood in Pilots During 37 h Without Sleep, Aviat Space Environ Med. 75(9), pp. 77-84, 2004.
  8. Caldwell J A, Mallis M M, Caldwell J L, Paul M A, Miller J C, Neri D F, Aerospace Medical Association Aerospace Fatigue Countermeasures Subcommittee of The Human Factor Committee, Fatigue Countermeasures in Aviation, Aviat Space Environ Med. 80, pp. 29-59, 2009.
  9. Childs E, de Wit H, Enhanced Mood and Psychomotor Performance by a Caffeine-containing Energy Capsule in Fatigued Individuals, Exp Clin Psychopharmacol. 16(1), pp. 13-21, 2008. https://doi.org/10.1037/1064-1297.16.1.13
  10. Daly JW, Jacobson KA, Ukena D, Adenosine Receptors : Development of Selective Agonists and Antagonists, Prog Clin Biol Res. 230(1), pp. 41-63, 1987.
  11. Del Arco A, Gonzalez-Mora JL, Armas VR, Mora F, Amphetamine Increases the Extracellular Concentration of Glutamate in Striatum of the Awake Rat : Involvement of High Affinity Transporter Mechanisms, Neuropharmacology 38(7), pp. 943-54, 1999. https://doi.org/10.1016/S0028-3908(99)00043-X
  12. Fisone G, Borgkvist A, Usiello A, Caffeine as a Psychomotor Stimulant : Mechanism of Action, Cell Mol Life Sc.i. 61(7-8), pp. 857-72, 2004. https://doi.org/10.1007/s00018-003-3269-3
  13. Gill M, Haerich P, Westcott K, Godenick K L, Tucker J A, Cognitive Performance Following Modafinil Versus Placebo in Sleep-deprived Emergency Physicians : A Double-blind Randomized Crossover Study, Acad Emerg Med. 13(2), pp. 158-165, 2006. https://doi.org/10.1111/j.1553-2712.2006.tb01665.x
  14. Hadley S, Petry J J, Valerian. Am Fam Physician, 67, pp. 1755-1758, 2003.
  15. Hampson R E, Espana R A, Rogers G A, Porrino L J, Deadwyler S A, Mechanisms Underlying Cognitive Enhancement and Reversal of Cognitive Deficits in Nonhuman Primates by the Ampakine CX717, Psychopharmacology 202(1-3), pp. 355-69, 2009. https://doi.org/10.1007/s00213-008-1360-z
  16. Harsh J R, Hayduk R, Rosenberg R, The Efficacy and Safety of Armodafinil as Treatment for Adults with Excessive Sleepiness Associated with Narcolepsy, Curr Med Res Opin. 22(4), pp. 761-774, 2006. https://doi.org/10.1185/030079906X100050
  17. Huck N O, McBride S A, Kendall A P, Grugle N L, Killgore W D, The Effects of Modafinil, Caffeine, and Dextroamphetamine on Judgments of Simple Versus Complex Emotional Expressions Following Sleep Deprivation, Int J Neurosci. 118(4), pp. 487-502, 2008. https://doi.org/10.1080/00207450601125907
  18. Hyams, K C, Hanson, K, Wignall, F S, Escamilla, J, Oldfield, E C, The Impact of Infectious Diseases on the Health of US Troops Depolyed to the Persian Gulf During Operations Desert Shield and Desert Storm, Clin, Infect. Dis., 20, 1497, 1995. https://doi.org/10.1093/clinids/20.6.1497
  19. Killgore W D, Rupp T L, Grugle N L, Reichardt R M, Lipizzi E L, Balkin T J, Effects of Dextroamphetamine, Caffeine and Modafinil on Psychomotor Vigilance Test Performance After 44 h of Continuous Wakefulness, J Sleep Res. 17(3), pp. 309-321, 2008 https://doi.org/10.1111/j.1365-2869.2008.00654.x
  20. Knapp, P, Amphetamine and Addiction, Journal of Nervous and Mental Disorders, 115, pp. 406-409, 1952.
  21. Leith N, Kuczenski R, Chronic Amphetamine : Tolerance and Reverse Tolerance Reflect Different Behavioral Actions of the Drug, Pharmacol. Biochem. Behav., 15(3), pp. 399-404, 1981. https://doi.org/10.1016/0091-3057(81)90269-0
  22. Lewy A J, Emens J, Jackman A, Yuhas K, Circadian Uses of Melatonin in Humans, Chronobiol Int 23, pp. 403-412, 2006. https://doi.org/10.1080/07420520500545862
  23. Lu L, Shepard J D, Hall F S, Shaham Y, Effect of Environmental Stressors on Opiate and Psychostimulant Reinforcement, Reinstatement and Discrimination in Rats : a Review, Neurosci Biobehav Rev. 27(5), pp. 457-491, 2003 https://doi.org/10.1016/S0149-7634(03)00073-3
  24. Madras, B. K. et al. J, Pharmacol, Exp. Therapeutics 319, pp. 561-569, 2006. https://doi.org/10.1124/jpet.106.106583
  25. Makris A P, Rush C R, Frederich R C, Taylor A C, Kelly T H, Behavioral and Subjective Effects of D-amphetamine and Modafinil in Healthy Adults, Exp Clin Psychopharmacol, 15(2), pp. 123-133, 2007. https://doi.org/10.1037/1064-1297.15.2.123
  26. Menza M A, Kaufman K R, Castellanos A, Modafinil Augmentation of Antidepressant Treatment in Depression, J Clin Psychiatry. 61(5), pp. 378-381, 2000. https://doi.org/10.4088/JCP.v61n0510
  27. Monti J M, Primary and Secondary Insomnia : Prevalence, Causes and Current Therapeutics, Curr Med Chem Cent Nerv Syst Agents 4, pp. 119-137, 2004. https://doi.org/10.2174/1568015043357039
  28. Ortweiler W, Simon H U, Splinter F K, Peiker G, Siegert C, Traeger A, Determination of Caffeine and Metamizole Elimination in Pregnancy and After Delivery as an in Vivo Method for Characterization of Various Cytochrome p-450 Dependent Biotransformation Reactions, Biomed Biochim Acta., 44(7-8), pp. 1189-1199, 1985.
  29. Perkins A M, Ettinger U, Davis R, Foster R, Williams S C, Corr P J, Effects of Lorazepam and Citalopram on Human Defensive Reactions : Ethopharmacological Differentiation of Fear and Anxiety, J Neurosci. 29(40), pp. 12617-12624, 2009. https://doi.org/10.1523/JNEUROSCI.2696-09.2009
  30. Roth T, White D, Schmidt-Nowara W, Effects of Armodafinil in the Treatment of Residual Excessive Sleepiness Associated with Obstructive Sleep Apnea /Hypopnea Syndrome : A 12-week, Multicenter, Double-blind, Randomized, Placebo-controlled Study in nCPAP-adherent Adults, Clin Ther. 28(5), pp. 689-706, 2006. https://doi.org/10.1016/j.clinthera.2006.05.013
  31. Scholl J L, Feng N, Watt M J, Renner K J, Forster G, Individual Differences in Amphetamine Sensitization, Behavior and Central Monoamines, Physiol Behav. 96(3), pp. 493-504, 2009. https://doi.org/10.1016/j.physbeh.2008.12.001
  32. Volkow, N. D. et al, Effects of Modafinil on Dopamine Transporters in the Male Human Brain : Clinical Implications, JAMA 301, pp. 1148-1154, 2009. https://doi.org/10.1001/jama.2009.351
  33. Wesensten N J, Effects of Modafinil on Cognitive Performance and Alertness During Sleep Deprivation, Curr Pharm Des. 12(20), pp. 2457-2471, 2006. https://doi.org/10.2174/138161206777698819
  34. Wikipedia, "Cortex News & Events", http://www.cortexpharm.com/html/news/06/06-21-06.html, 2009.