Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Astragali Radix on Brain Edema and Apoptosis in Intracerebral Hemorrhage of Rats

황기(黃芪)가 Intracerebral Hemorrhage 흰쥐의 뇌부종(腦浮腫)에 미치는 영향

  • Jung, Hyung-Jin (Department of Anatomy-Pointlogy, College of Oriental Medicine, Kyungwon University) ;
  • Park, Wan-Su (Department of Pathology, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Youn-Sub (Department of Anatomy-Pointlogy, College of Oriental Medicine, Kyungwon University)
  • 정형진 (경원대학교 한의과대학 해부경혈학교실) ;
  • 박완수 (경원대학교 한의과대학 병리학교실) ;
  • 김연섭 (경원대학교 한의과대학 해부경혈학교실)
  • Received : 2010.10.06
  • Accepted : 2010.12.06
  • Published : 2010.12.25
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Abstract

This study aimed to evaluate the effects of Astragali radix on brain edema of intracerebral hemorrhage(ICH)-induced rats. Brain edema following ICH was induced via the stereotaxic intrastriatal injection of bacterial collagenase type VII in Sprague-Dawley rats. Ethanol extract of Astragli radix was treated once a day for 3 days. Then brain hematoma volume and edema were examined. Immunohistochemistry was processed for iNOS, c-Fos, Bax, and HSP72 expressions in the brain sections and each immuno-labeling were calculated with image analysis. Ethanol extract of Astragli radix reduced hematoma volume(not significantly) and brain edema(significantly) ICH induced rats. Ethanol extract of Astragli radix reduced iNOS expressions, c-Fos, Bax and HSP72 positive cells significantly and reduced apoptotic bodies and swollen neurons in ICH induced rat brain. These results suggest that Astragli radix plays an inhibitory role in the hemorrhagic, inflammatory and apoptotic events induced by ICH. And it is supposed that neuroprotective effect of Astragli radix reveals by anti-apoptosis mechanism.

Keywords

References

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