Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Triticum aestivum sprout on Blood Glucose and Lipid Levels in the Streptozotocin-Induced Diabetic Mice

소맥엽의 섭취가 Streptozotocin 유발 당뇨 흰쥐에서 혈중 포도당 및 지질에 미치는 영향

  • Lee, Sun-Hee (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School) ;
  • Lim, Sung-Won (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School) ;
  • Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kang, Chun-Sik (Department of Rice and Winter Cereal Crop, NICS, RDA) ;
  • Cheong, Young-Keun (Department of Rice and Winter Cereal Crop, NICS, RDA) ;
  • Park, Chul-Soo (Department of Rice and Winter Cereal Crop, NICS, RDA) ;
  • Song, Bong-Joon (Chong Kun Dang Healthcare Corp. Research Center) ;
  • Kim, Dae-Ki (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School)
  • 이선희 (전북대학교 의과대학 및 의과학연구소) ;
  • 임성원 (전북대학교 의과대학 및 의과학연구소) ;
  • 이영미 (원광대학교 약학대학 한약학과) ;
  • 강천식 (농촌진흥청 국립식량과학원) ;
  • 정연근 (농촌진흥청 국립식량과학원) ;
  • 박철수 (농촌진흥청 국립식량과학원) ;
  • 송봉준 (종근당 건강(주)) ;
  • 김대기 (전북대학교 의과대학 및 의과학연구소)
  • Received : 2010.09.10
  • Accepted : 2010.11.02
  • Published : 2010.12.25
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Abstract

This study investigated the functional effect by diets of Triticum aestivum sprout (TA) on the levels of blood glucose and lipid profiles in streptozotocin(STZ)-induced diabetic mice. Diabetes mellitus were induced by STZ intraperitoneal injection (50 mg/kg) into the male Balb/c mice. All mice fed AIN-93 diet for 3 weeks. Mice were divided to 4 groups: normal, diabetic control and two experimental groups (TA 5.0, diet with Triticum aestivum sprout 5.0% w/w; TA 2.5, diet with Triticum aestivum 2.5% w/w). The blood glucose level was decreased by TA intake in diabetic mice in the dose-dependant manner; 21.34% and 35.77% in TA 2.5 and TA 5.0 groups. The weight gain and feed efficiency ratio also were improved by TA intake compared with DM group. The weight gain was increased 1.28 and 1.09 folds in TA 5.0 and TA 2.5 groups, respectively. The weight of organs, including liver and kidney, was reduced but that of spleen and abdominal fat was increased by TA intake. Moreover, TA treatment increased the level of HDL but decreased the level of total cholesterol and triglycerides in the blood of diabetic mice. The blood of HbA1c also was significantly decreased without changing hematocrit by TA treatment compared with DM group. These results indicate the TA intake has the functional effects attenuating blood glucose and plasma lipid levels in insulin-dependent diabetes.

Keywords

References

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