Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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Relationship between the Expression of VEGF, HIF-1α, E-cadherin, p53 and Stage in Papillary Thyroid Carcinoma

유두상 갑상선암에서 VEGF, HIF-1α, E-cadherin, p53의 발현과 병기의 관련성 연구

  • Kim, Jong-Sam (Department of Public Health, The Graduate School of Public Health and Welfare Konyang University) ;
  • Na, Baeg-Ju (Department of Preventive Medicine, College of Medicine, Konyang University) ;
  • Lee, Moo-Sik (Department of Preventive Medicine, College of Medicine, Konyang University) ;
  • Kim, Chul-Woung (Department of Preventive Medicine, College of Medicine, Konyang University) ;
  • Jeong, Gye-Rim (Department of Public Health, The Graduate School of Konyang University)
  • 김종삼 (건양대학교 보건복지대학원 보건학과) ;
  • 나백주 (건양대학교 의과대학 예방의학교실) ;
  • 이무식 (건양대학교 의과대학 예방의학교실) ;
  • 김철웅 (건양대학교 의과대학 예방의학교실) ;
  • 정계림 (건양대학교 일반대학원 보건학과)
  • Received : 2009.07.16
  • Accepted : 2010.03.18
  • Published : 2010.03.31
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Abstract

The purpose of our study was to evaluate the correlation between expression of VEGF, HIF-$1{\alpha}$, E-cadherin, and p53 and pathologic stage. We retrospectively reviewed the medical records of the 101 patients who underwent surgery of thyroid nodules from 2000 to 2007. Expression of VEGF, HIF-$1{\alpha}$, E-cadherin, and p53 were examinated immunohistochemically. Papillary thyroid carcinoma in this study included 54 cases of more than 45 years old. Each expression of VEGF, HIF-$1{\alpha}$, E-cadherin, and p53 was analysed. Only expression loss of E-cadherin was associated with the stage. High HIF-1 expression was significantly associated with VEGF immunoreactivity (p<0.05). Expression loss of E-cadherin was independent unfavorable factors. It is suggested that high HIF-$1{\alpha}$ expression may be associated with intratumoral neovascularization possibly through HIF-VEGF pathway.

이 연구는 갑상샘 유두암 환자에서 VEGF, HIF-$1{\alpha}$, E-cadherin, p53의 발현 정도와 병기와의 상관관계를 알아보고자 하였다. 2000년부터 2007년까지 갑상샘 절제술을 시행받은 101명의 환자의 의무기록을 후향적으로 검토하였다. VEGF, HIF-$1{\alpha}$, E-cadherin, p53의 발현은 면역학적으로 조사되었다. 갑상샘 유두암으로 진단된 45세 이상의 환자 중 54명을 대상으로 하여 VEGF, HIF-$1{\alpha}$, E-cadherin, p53의 발현이 분석되었다. E-cadherin의 발현소실과 병기 사이에는 유의한 상관관계가 있었다. VEGF의 발현과 HIF-$1{\alpha}$의 과발현 사이에는 유의한 관련성이 관찰되었다(p<0.05). E-cadherin의 발현소실은 통계적인 유의성은 없었다. HIF-$1{\alpha}$의 높은 발현이 HIF-VEGF 경로를 통해 종양간 맥관형성과 관련된 것으로 여겨진다.

Keywords

References

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