Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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The Factors that Predict Using Mechanical Ventilation for Patients with Organophosphate Intoxication

유기인계 농약 중독환자에서 기계환기 필요성에 대한 예측인자 분석

  • Park, Dong-Chan (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Park, Jung-Bae (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Kim, Yun-Jeong (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Shin, Soo-Jeong (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Mun, You-Ho (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Park, Sin-Ryul (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Ryoo, Hyun-Wook (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Seo, Kang-Suk (Department of Emergency Medicine, College of Medicine, The Kyungpook National University) ;
  • Chung, Jae-Myung (Department of Emergency Medicine, College of Medicine, The Kyungpook National University)
  • 박동찬 (경북대학교 의과대학 응급의학교실) ;
  • 박정배 (경북대학교 의과대학 응급의학교실) ;
  • 김윤정 (경북대학교 의과대학 응급의학교실) ;
  • 신수정 (경북대학교 의과대학 응급의학교실) ;
  • 문유호 (경북대학교 의과대학 응급의학교실) ;
  • 박신률 (경북대학교 의과대학 응급의학교실) ;
  • 류현욱 (경북대학교 의과대학 응급의학교실) ;
  • 서강석 (경북대학교 의과대학 응급의학교실) ;
  • 정제명 (경북대학교 의과대학 응급의학교실)
  • Received : 2010.07.14
  • Accepted : 2010.08.18
  • Published : 2010.12.31
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Abstract

Purpose: The purpose of this study is to investigate the factors that predict using mechanical ventilation for patients with organophosphate intoxication. Methods: We retrospectively reviewed the medical records of 111 patients with acute organophosphate intoxication and who were treated in our emergency center from January 2000 to December 2008. We compared the toxicologic characteristics, the laboratory findings and the APACHE II scores between the Mechanical Ventilation group (MV group) and the non-Mechanical Ventilation group (the non MV group). Results: Sixty three patients were in the MV group and 48 patients were in the non MV group. In the MV group, the patients had an older age (p<0.001), a larger amount of ingestion (p<0.001), a lower initial serum cholinesterase level (p=0.003), a higher APACHE II score (p<0.001) and they ingested a more toxic agent (p=0.001). There were no significant differences in gender, the type of visit and the arrival time between the MV group and the non MV group. Conclusion: We suggest that the patient's age, the amount of organophosphate ingestion, the toxicity of the agent, the initial serum cholinesterase level and the APACHE II score are important factors to determine if mechanical ventilation will be applied for patients with organophosphate intoxication.

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