DOI QR코드

DOI QR Code

단독 대동맥판막 폐쇄부전 환자에서 대동맥판막 치환술 후 좌심실 질량의 변화

Regression of Left Ventricular Mass after Aortic Valve Replacement in Isolated Aortic Regurgitation

  • 정태은 (영남대학교 의과대학 흉부외과학교실) ;
  • 이동협 (영남대학교 의과대학 흉부외과학교실) ;
  • 이석수 (영남대학교 의과대학 흉부외과학교실)
  • Jung, Tae-Eun (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University) ;
  • Lee, Dong-Hyup (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University) ;
  • Lee, Seok-Soo (Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yeungnam University)
  • 투고 : 2010.09.29
  • 심사 : 2010.11.12
  • 발행 : 2010.12.05

초록

배경: 단독 대동맥판막 폐쇄부전증(AR) 환자에서 단독 대동맥판막 치환술 후 좌심실질량 감소의 정도를 평가하고자 하였다. 대상 및 방법: 2002년부터 2007년까지 대동맥판막 폐쇄부전증으로 단순 대동맥판막 치환술을 시행한 20명을 대상으로 수술 전과 수술 후 1년에 심초음파 검사결과를 후향적으로 조사하였다. 대상환자는 남자 12명, 여자 8명, 평균연령 $55.8{\pm}11.8$세, 평균체표면적 $1.64{\pm}0.19m^2$이었다. 대조군은 심초음파상 병변이 발견되지 않은 비슷한 나이의 41명을 대상으로 하였다. 대동맥판막 치환술 이외의 복합시술을 시행한 환자와 감염성 심내막염 환자는 제외하였다. 결과: 수술에 사용된 판막의 종류는 조직판막이 7명, 기계판막이 13명에서 사용되었으며 크기는 21 mm가 3명, 23 mm가 13명 그리고 25 mm가 4명에서 사용되었다. 수술 후 좌심실질량계수(LVMI, $125.5{\pm}42g/m^2$)는 술전에 비해 유의하게 감소하였으나($212.3{\pm}80g/m^2$, p=0.000) 대조군($80.5{\pm}15.9g/m^2$, p=0.000)에 비해 높았다. 수술 전후의 심실중격(확장기/수축기: $13.5{\pm}3.4mm/17.1{\pm}4.1mm$)과 좌심실 후벽(확장기/수축기: $12.9{\pm}3.4mm/16.7{\pm}3.4mm$)의 두께는 수술 전에 비해 일부 감소가 있었으나 통계적으로 유의하지 않았으며 각각 대조군(확장기/수축기 $8.6{\pm}1.4mm/12.1{\pm}1.7mm$, 확장기/수축기 $8.4{\pm}1.4mm/13.2{\pm}1.9mm$)보다 유의하게 높았다(p < 0.001). 결론: 단독 대동맥판막 폐쇄부전으로 단독 대동맥판막 치환술 시행 1년 후 주로 좌심실용적의 감소에 의한 LVMI의 유의한 감소가 있었으나 대조군에 비해서는 여전히 높았다.

Background: The aim of our study was to assess the extent of regression of left ventricular mass after aortic valve replacement in isolated aortic regurgitation. Material and Method: Retrospective analysis of echocardiographic data was collected preoperative and postoperative 1 year. There were 20 patients (12 males, 8 females, mean age $55.8{\pm}11.8$ years, mean body surface area $1.64{\pm}0.19m^2$) with aortic regurgitation from 2002 through 2007. We studied the change of left ventricular ejection fraction, ventricular septum and left ventricular posterior wall thickness, and left vemtricular muscle index (LVMI). The control group was age matched with normal echocardiographic study results. Patients with combined surgery or infective endocarditis were excluded. Result: Seven cases of tissue valves and thirteen cases of mechanical valve were used. The valve sizes were 21 mm (3 cases), 23 mm (13 cases) and 25 mm (4 cases). The postoperative ($125.5{\pm}42g/m^2$) LVMI has decreased than preoperative LVMI ($212.3{\pm}80g/m^2$, p=0.000) but higher than that of control group ($80.5{\pm}15.9g/m^2$, p=0.000). Postoperative septal wall (systolic/diastolic: $13.5{\pm}3.4mm/17.1{\pm}4.1mm$) and left ventricular posterior wall (systolic/diastolic: $12.9{\pm}3.4mm/16.7{\pm}3.4mm$) thickness were slightly decreased after the valve replacement but was not significantly different than preoperative levels. And postoperative interventricular septal wall and left ventricular posterior wall thickness (systolic/diastolic: $8.6{\pm}1.4mm/12.1{\pm}1.7mm$, systolic/diastolic: $8.4{\pm}1.4mm/13.2{\pm}1.9mm$) were higher than that of the control group (p<0.001). Conclusion: The significant regression of LVMI after aortic valve replacement developed at postoperative one year but the level was higher than control group. The main cause of decreased LVMI is decreased in left ventricular dimension.

키워드

참고문헌

  1. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986;57:450-8. https://doi.org/10.1016/0002-9149(86)90771-X
  2. Monrad ES, Hess OM, Murakami T, Nonogi H, Corin WJ, Krayenbuehl HP. Time course of regression of left ventricular hypertrophy after aortic valve replacement. Circulation 1988;77:1345-55. https://doi.org/10.1161/01.CIR.77.6.1345
  3. Kennedy JW, Doces J, Stewart DK. Left ventricular function before and following aortic valve replacement. Circulation 1977;56:944-50. https://doi.org/10.1161/01.CIR.56.6.944
  4. Hess OM, Ritter M, Schneider J, Grimm J, Turina M, Krayenbuehl HP. Diastolic stiffness and myocardial structure in aortic valve disease before and after valve replacement. Circulation 1984;69:855-65. https://doi.org/10.1161/01.CIR.69.5.855
  5. Villari B, Vassalli G, Monrad ES, Chiariello M, Turina M, Hess OM. Normalization of diastolic dysfunction in aortic stenosis late after valve replacement. Circulation 1995;91: 2353-8. https://doi.org/10.1161/01.CIR.91.9.2353
  6. Pantely G, Morton M, Rahimtoola SH. Effects of successful, uncomplicated valve replacement on ventricular hypertrophy, volume, and performance in aortic stenosis and in aortic incompetence. J Thorac Cardiovasc Surg 1978;75:383-91.
  7. Krayenbuehl HP, Hess OM, Monrad ES, Schneider J, Mall G, Turina M. Function and structure of the failing left ventricular myocardium in aortic valve disease before and after valve replacement. Basic Res Cardiol 1991;86(Suppl 3):175-85.
  8. Taniguchi K, Kawamaoto T, Kuki S, et al. Left ventricular myocardial remodeling and contractile state in chronic aortic regurgitation. Clin Cardiol 2000;23:608-14. https://doi.org/10.1002/clc.4960230812
  9. Sutton M, Plappert T, Spiegel A, et al. Early postoperative changes in left ventricular chamber size, architecture, and function in aortic stenosis and aortic regurgitation and their relation to intraoperative changes in afterload: a prospective two-dimensional echocardiographic study. Circulation 1987; 76:77-89. https://doi.org/10.1161/01.CIR.76.1.77
  10. Vasan RS, Levy D. The role of hypertension in the pathogenesis of heart failure. A clinical mechanistic overview. Arch Intern Med 1996;156:1789-96. https://doi.org/10.1001/archinte.156.16.1789
  11. Murakami T, Hess OM, Gage JE, Grimm J, Krayenbuehl HP. Diastolic filling dynamics in patients with aortic stenosis. Circulation 1986;73:1162-74. https://doi.org/10.1161/01.CIR.73.6.1162
  12. Polese A, De Cesare N, Montorsi P, et al. Upward shift of the lower range of coronary flow autoregulation in hypertensive patients with hypertrophy of the left ventricle. Circulation 1991;83:845-53. https://doi.org/10.1161/01.CIR.83.3.845
  13. Levy D, Anderson KM, Savage DD, Balkus SA, Kannel WB, Castelli WP. Risk of ventricular arrhythmias in left ventricular hypertrophy: the Framingham Heart Study. Am J Cardiol 1987;60:560-5. https://doi.org/10.1016/0002-9149(87)90305-5
  14. Hanayama N, Christakis GT, Mallidi HR, et al. Determinants of incomplete left ventricular mass regression following aortic valve replacement for aortic stenosis. J Card Surg 2005;20:307-13. https://doi.org/10.1111/j.1540-8191.2005.200485.x