Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제36권6호
  • /
  • Pages.502-507
  • /
  • 2010
  • /
  • 2234-7550(pISSN)
  • /
  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지
DOI QR코드

DOI QR Code

한국인 하악전돌증환자의 유전적 영향과 유전율에 대한 분석

Genetic influence and heritability in mandibular prognathism of Korean families

  • 김영호 (성균관대학교 의과대학 삼성서울병원 교정과) ;
  • 조한영 (성균관대학교 의과대학 삼성서울병원 교정과) ;
  • 백채환 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 이아영 (성균관대학교 의과대학 삼성서울병원 교정과) ;
  • 김군종 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 김휘영 (삼성의료원 미래의학연구센터) ;
  • 서영주 (인하대학교 의학전문대학원 임상연구부) ;
  • 백승학 (서울대학교 치의학전문대학원 교정과) ;
  • 홍종락 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 팽준영 (성균관대학교 의과대학 삼성서울병원 구강악안면외과)
  • Kim, Young-Ho (Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Cho, Han-Young (Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Baek, Chae-Hwan (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Lee, Ah-Young (Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Kim, Gun-Jong (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Kim, Whi-Young (Research Center for Future Medicine, Samsung Medical Center) ;
  • Suh, Young-Ju (Clinical Research Institute, School of Medicine, Inha University) ;
  • Baek, Seung-Hak (Department of Orthodontics, School of Dentistry, Dental Research Institute, Seoul National University) ;
  • Hong, Jong-Rak (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Paeng, Jun-Young (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University)
  • 투고 : 2010.08.31
  • 심사 : 2010.12.17
  • 발행 : 2010.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were $81.2^{\circ}$, $84.1^{\circ}$ and $-2.9^{\circ}$, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability ($h^2$, Falconer' method) was estimated to be 29.8% ($0.298{\pm}0.059$) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion.

키워드

참고문헌

  1. Nakasima A, Ichinose M, Nakata S. Genetic and environmental factors in the development of so-called pseudo- and true mesiocclusions. Am J Orthod Dentofacial Orthop 1986;90:106-16. https://doi.org/10.1016/0889-5406(86)90041-7
  2. Litton SF, Ackermann LV, Isaacson RJ, Shapiro BL. A genetic study of Class 3 malocclusion. Am J Orthod 1970;58:565-77. https://doi.org/10.1016/0002-9416(70)90145-4
  3. Newman GV. Prevalence of malocclusion in children six to fourteen years of age and treatment in preventable cases. J Am Dent Assoc 1956;52:566-75. https://doi.org/10.14219/jada.archive.1956.0092
  4. Emrich RE, Brodie AG, Blayney JR. Prevalence of Class 1, Class 2, and Class 3 malocclusions (Angle) in an urban population. An epidemiological study. J Dent Res 1965;44:947-53. https://doi.org/10.1177/00220345650440053301
  5. Proffit WR, Fields HW, Jr., Moray LJ. Prevalence of malocclusion and orthodontic treatment need in the United States: estimates from the NHANES III survey. Int J Adult Orthodon Orthognath Surg 1998;13:97-106.
  6. Garner LD, Butt MH. Malocclusion in black Americans and Nyeri Kenyans. An epidemiologic study. Angle Orthod 1985;55: 139-46.
  7. Ishii H, Morita S, Takeuchi Y, Nakamura S. Treatment effect of combined maxillary protraction and chincap appliance in severe skeletal Class III cases. Am J Orthod Dentofacial Orthop 1987; 92:304-12. https://doi.org/10.1016/0889-5406(87)90331-3
  8. Kang HK, Ryu YK. A study on the prevalence of malocclusion of Yonsei university students in 1991. Korean J Orthod 1992;22: 691-701.
  9. Yoo YK, Kim NI, Lee HK. A study on the prevalence of malocclusion 2,378 Yonsei university students. Korean J Orthod 1971;2:35-40.
  10. Pascoe JJ, Hayward JR, Costich ER. Mandibular prognathism: its etiology and a classification. J Oral Surg Anesth Hosp Dent Serv 1960;18:21-4.
  11. Gold JK. A new approach to the treatment of mandibular prognathism. Am J Orthod 1949;35:893-912, illust. https://doi.org/10.1016/0002-9416(49)90085-8
  12. Watanabe M, Suda N, Ohyama K. Mandibular prognathism in Japanese families ascertained through orthognathically treated patients. Am J Orthod Dentofacial Orthop 2005;128:466-70. https://doi.org/10.1016/j.ajodo.2004.09.018
  13. Wolff G, Wienker TF, Sander H. On the genetics of mandibular prognathism: analysis of large European noble families. J Med Genet 1993;30:112-6. https://doi.org/10.1136/jmg.30.2.112
  14. El-Gheriani AA, Maher BS, El-Gheriani AS, Sciote JJ, Abu- Shahba FA, Al-Azemi R, et al. Segregation analysis of mandibular prognathism in Libya. J Dent Res 2003;82:523-7. https://doi.org/10.1177/154405910308200707
  15. Cruz RM, Krieger H, Ferreira R, Mah J, Hartsfield J Jr, Oliveira S. Major gene and multifactorial inheritance of mandibular prognathism. Am J Med Genet A 2008;146A:71-7. https://doi.org/10.1002/ajmg.a.32062
  16. Falconer DS, MacKay TFC. Introduction to quantitative genetics. 4th ed. Essex, England: Longman; 1996.
  17. Falconer DS. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 1965;29:51-76. https://doi.org/10.1111/j.1469-1809.1965.tb00500.x
  18. Lee CH, Lee SH, Kim HS, Kwon TG. Analysis of familial tendency in skeletal class III malocclusion. J Korean Assoc Oral Maxillofac Surg 2006;32:506-13.
  19. Jacobson A, Evans WG, Preston CB, Sadowsky PL. Mandibular prognathism. Am J Orthod 1974;66:140-71. https://doi.org/10.1016/0002-9416(74)90233-4
  20. Thompson EM, Winter RM. Another family with the 'Habsburg jaw'. J Med Genet 1988;25:838-42. https://doi.org/10.1136/jmg.25.12.838
  21. Oh J, Wang CJ, Poole M, Kim E, Davis RC, Nishimura I, et al. A genome segment on mouse chromosome 12 determines maxillary growth. J Dent Res 2007;86:1203-6. https://doi.org/10.1177/154405910708601212
  22. Dohmoto A, Shimizu K, Asada Y, Maeda T. Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains. J Dent Res 2002;81:501-4. https://doi.org/10.1177/154405910208100714
  23. Yamaguchi T, Park SB, Narita A, Maki K, Inoue I. Genomewide linkage analysis of mandibular prognathism in Korean and Japanese patients. J Dent Res 2005;84:255-9. https://doi.org/10.1177/154405910508400309
  24. Frazier-Bowers S, Rincon-Rodriguez R, Zhou J, Alexander K, Lange E. Evidence of linkage in a Hispanic cohort with a Class III dentofacial phenotype. J Dent Res 2009;88:56-60. https://doi.org/10.1177/0022034508327817
  25. Bui C, King T, Proffit W, Frazier-Bowers S. Phenotypic characterization of Class III patients. Angle Orthod 2006;76:564-9.

피인용 문헌

  1. Segregation analysis of mandibular prognathism in Korean orthognathic surgery patients and their families vol.83, pp.6, 2013, https://doi.org/10.2319/021313-130.1