Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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CD11b as a Biomarker for Canine Systemic Inflammatory Response Syndrome and Sepsis

개 전신성염증반응증후군 및 패혈증의 진단적 표지자로서 CD11b의 활용

  • Yu, Do-Hyeon (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Noh, Dong-Ho (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Song, Ru-Hui (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Kim, Jun-Hwan (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Lee, Da-Mi (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Kim, Sue-Hee (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Park, Chul (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University) ;
  • Park, Jin-Ho (College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University)
  • 유도현 (전북대학교 수의과대학) ;
  • 노동호 (전북대학교 수의과대학) ;
  • 송루희 (전북대학교 수의과대학) ;
  • 김준환 (전북대학교 수의과대학) ;
  • 이다미 (전북대학교 수의과대학) ;
  • 김수희 (전북대학교 수의과대학) ;
  • 박철 (전북대학교 수의과대학) ;
  • 박진호 (전북대학교 수의과대학)
  • Accepted : 2010.10.11
  • Published : 2010.12.31
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Abstract

The aim of this study is to investigate neutrophil activation markers among canine ICU (intensive care unit) control, systemic inflammatory response syndrome (SIRS) and sepsis. These markers include WBC (white blood cells), platelets counts, blood film examination (neutrophilic band to segmentation ratio and neutrophilic degenerative changes), and flow cytometric analysis (CD11b expression of neutrophils). As a result, the mean CD11b fluorescence intensity of neutrophils and the neutrophilic degenerative change scores were both significantly higher in sepsis group (P<0.05). In addition, mortality was also found to be correlated with the up-regulation of CD11b expression in circulating neutrophils. This study demonstrates that CD11b expression of neutrophils could be more a reliable biomarker to predict prognosis in ICU patients than traditional blood film examination according to this study.

본 연구는 중환자의 개에서 전신성염증반응증후군 및 패혈증에 의하여 유발되는 백혈구 활성화 지표를 분석하기 위하여 실행되었다. 분석된 지표로는 백혈구 수치, 혈소판 수치, 혈액 도말 표본의 백혈구 변화상 및 백혈구 표면의 CD11b발현 정도 등을 검사하였다. 그 결과, 패혈증군에서 백혈구의 CD11b 발현 값 (유세포 분석)이 현저하게 높게 관찰되었으며(P<0.05), 퇴행성 변화 정도도 같은 군에서 현저하게 높게 관찰 되었다(P<0.05). 또한 비 생존군의 CD11b 발현 값도 생존군에서의 값보다 현저하게 높았다. 이러한 연구 결과로 볼 때, 백혈구의 CD11b 발현은 중환자의 개에서 그 예후를 평가하는데 유용하다고 여겨진다.

Keywords

References

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