Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

Arthritis on Temporomandibular Joint in Rabbit by Collagenase Injection

가토의 하악관절에 Collagenase 주입을 통한 관절염 유발 모델에 관한 연구

  • Song, Dong-Seok (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Kim, Ki-Hyun (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Lee, Jae-Yeol (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Jung, Eu-Gene (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Ahn, Sang-Wook (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Song, Jin-Woo (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Kim, Chul-Hun (Department of Oral & Maxillofacial Surgery, Department of Dentisry, Dong-A University Medical Center) ;
  • Shin, Sang-Hun (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University) ;
  • Chung, In-Kyo (Department of Oral & Maxillofacial surgery, School of Dentistry, Pusan National University)
  • 송동석 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김기현 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 이재열 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 정유진 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 안상욱 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 송진우 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김철훈 (동아대학교 의과대학 치의학교실 구강악안면외과) ;
  • 신상훈 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 정인교 (부산대학교 치의학전문대학원 구강악안면외과학교실)
  • Received : 2010.09.20
  • Accepted : 2010.10.26
  • Published : 2010.11.30
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Abstract

Purpose: The purpose of this study is to induce artificial arthritis on rabbit TMJ by injecting collagenase. Materials and Methods: An experimental animal model of arthritis induced by surgical method or intraarticular injection of chemical agent like LDH, papain, ketorolac. Surgical method is complex and needs a long time in inducing arthritis. Intra-articular injection of chemical agent like LDH, papain, ketorolac is simple. But chemical agent like LDH, papain, ketololac needs multiple injections to induce arthritis and mechanism inducing arthritis was known. Collagenase destroys helical domain of type II collagen in extracellular matrix produced by chondrocyte and then induces arthritis. We injected collagenase (0.5, 1.0, 2.0 mg) into the temporomandibular joint of rabbit. In the control group saline was intra-articularly injected. The condylar cartilage, disk and synovia were histologically examined at 1, 2, 4, 6 weeks after the initiation of collagenase injections. Results: Four weeks after injection of 2.0 mg collagenase, we could see histologic change like arthritis. In other groups, we couldn't see arthritis-like change. Conclusion: In our study, we produce arthritis on temporomandibular joint of rabbit by using injection of collagenase in temporomandibular joint of rabbit. And this experimental osteoarthritis is a useful animal model.

Keywords

References

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