Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Anti-HCV Activity of 3',5'-cyclic SATE Phosphonodiester Nucleoside as a Novel Prodrug

  • Liu, Lian Jin (KAST PHARM CO., LTD. #516 Hanyang University) ;
  • Seo, Rac-Seok (KAST PHARM CO., LTD. Hanyang University) ;
  • Yoo, Seung-Won (KAST PHARM CO., LTD. Hanyang University) ;
  • Choi, Jin (BK21- Project Team, College of Pharmacy, Chosun University) ;
  • Hong, Joon-Hee (BK21- Project Team, College of Pharmacy, Chosun University)
  • Published : 2010.04.20
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Abstract

A novel 2',4'-dimethyl carbocyclic adenosine 5'-phosphonic acid analogue (20) was prepared using acyclic stereoselective route from commercially available 4-hydroxybutan-2-one (4). To improve cellular permeability and enhance the anti-HCV activity of this phosphonic acid, a 3',5'-cyclic SATE phosphonodiester nucleoside prodrug (22) was prepared. The synthesized phosphonic nucleoside analogues, (20) and (22), were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line.

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References

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